Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, United States of America; Department of Physiology & Biophysics, University of California, Irvine, CA 92697, United States of America. Department of Physiology & Biophysics, University of California, Irvine, CA 92697, United States of America; Research Service, VA Long Beach Healthcare System, Long Beach, CA 90822, United States of America. Electronic address: pkiser@uci.edu.