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Prevention of gestational diabetes mellitus in overweight or obese pregnant women: A network meta-analysis.
Chatzakis, C, Goulis, DG, Mareti, E, Eleftheriades, M, Zavlanos, A, Dinas, K, Sotiriadis, A
Diabetes research and clinical practice. 2019;:107924
Abstract
AIMS: Several interventions have been implemented to prevent the development of gestational diabetes mellitus (GDM) in obese pregnant women, including physical exercise programs, and administration of metformin, vitamin D and probiotics. The aim of this network meta-analysis was to compare the efficiency of these interventions and identify the optimal. MATERIALS A network meta-analysis of randomized trials was performed comparing the different interventions for the development of GDM in overweight or obese women, either to each other or placebo/no intervention. A search was conducted in four electronic databases and grey literature sources. The primary outcome was the development of GDM; secondary outcomes were other complications of pregnancy. RESULTS The meta-analysis included 23 studies (4237 participants). None of the interventions was superior compared with placebo/no intervention for the prevention of GDM. Metformin and physical exercise were superior to placebo/no intervention for gestational weight gain (MD -1.21, 95% CI -2.14 to -0.28 and MD -0.96, 95% CI -1.69 to -0.22, respectively). Metformin was superior to placebo/no intervention for caesarean sections and admission to NICU. CONCLUSIONS Interventions aiming to prevent the development of GDM in overweight/obese women are not effective, when applied during pregnancy.
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Fighting obesity in children from European World Health Organization member states. Epidemiological data, medical-social aspects, and prevention programs.
Nittari, G, Scuri, S, Petrelli, F, Pirillo, I, di Luca, NM, Grappasonni, I
La Clinica terapeutica. 2019;(3):e223-e230
Abstract
Childhood obesity is one of the most serious public health chal-lenges of this century. Overweight and obese children are likely to stay obese into adulthood and more likely to develop non-communicable diseases like diabetes and cardiovascular diseases at a younger age. In the WHO European Region one child out of 3, is overweight or obese. Over 60% of children who are overweight before puberty will be overweight in early adulthood. Children and adolescents, aged 5-19 have shown rising obesity rates in almost all nations, including where the situation was far from alarming 40 years ago. Several nations have seen the prevalence almost double: Israel has gone from 5.8% in 1975 to 11.9% in 2016, Andorra from 6.2% to 12.8%, and Malta from 7.4% to 13.4%. Analyzing overweight and obesity, we can see that they follow similar trends and patterns. In 1975 the majority of European countries had a prevalence less than 10% and obesity less than 5%, while no European country had overweight prevalence higher than 30% and obe-sity higher than 10%. In 2016 the trend reversed, showing a worrying increase in the number of European countries with a high prevalence of overweight (over 30%) and obesity (over 10%) (Fig. 1)(29). Starting from the analysis of epidemiological data on obesity in the WHO European Region, the paper analyzes the adopted prevention programs in order to assess their effectiveness and figure out the best strategies to reduce the prevalence of overweight and obesity. The WHO European Childhood Obesity Surveillance Initiative reported that children tend to overeat and not to do enough physical exercise. Different preventive programs have identified different areas of action and corresponding measures: consumption of healthy foods, physical exercise, care before conception and during pregnancy, early childhood, school age children, weight management, monitoring and evaluation. Primary prevention is essential to reduce obesity incidence: it is easier to act on the adoption of healthy eating habits than intervene with diets on children who already have weight issues. Working on pre-vention programs represents an investment for the future of children's health. By simply acting on prevention, particularly on body weight reduction, it could be possible to tackle the spreading of correlated di-seases. Therefore, prevention programs ought to be prioritized priority at a national and international level.
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Considerations for Preterm Human Milk Feedings When Caring for Mothers Who Are Overweight or Obese.
Robinson, DT, Josefson, J, Van Horn, L
Advances in neonatal care : official journal of the National Association of Neonatal Nurses. 2019;(5):361-370
Abstract
BACKGROUND Mother's milk is the recommended source of nutrition for all newborns. Preterm infants may be further compromised by maternal factors that impede successful lactation and alter milk composition. PURPOSE To review and summarize the state of the science regarding implications of maternal overweight and obesity on successful lactation and associated alterations in preterm mother's milk composition. METHODS/SEARCH STRATEGY PubMed, EMBASE, and Web of Science searches were performed using relevant key words to identify references addressing maternal overweight or obesity, prematurity, human milk, and lactation. FINDINGS/RESULTS In the United States, more than half of women enter pregnancy with an overweight or obese body mass index. These women have increased risk of adverse pregnancy outcomes and obstetric complications that can undermine successful initiation and continuation of lactation, including preterm birth. Maternal overweight and obesity are also associated with alterations in mother's milk composition. IMPLICATIONS FOR PRACTICE Mother-preterm infant dyads affected by maternal overweight and obesity are at risk for barriers to initiation and continuation of lactation. Support for early initiation of milk expression is needed. Continued support, especially during the first weeks of lactation, can facilitate sustained milk production. IMPLICATIONS FOR RESEARCH Considerable knowledge gaps remain in this area of human milk science. Future research is needed to facilitate more comprehensive understanding of differences in milk composition associated with maternal overweight and obesity and their impact on clinical outcomes in the preterm infant.
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Barriers to the Implementation of Pediatric Overweight and Obesity Guidelines in a School-Based Health Center.
Yeager, LJ, Karp, SM, Leming-Lee, T'
The Nursing clinics of North America. 2019;(1):159-168
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Abstract
This project applied a quality improvement design to assess perceived barriers to pediatric overweight and obesity guideline implementation in school-based health centers. An electronic survey was administered to nurse practitioners and licensed practical nurses working in school-based health centers in New York. The most commonly cited primary care-based barriers were lack of patient compliance, family lifestyle, and the poor dietary practices and sedentary behaviors common in America. The most commonly cited school-based barriers were that children have little control over the groceries purchased and foods cooked at home and the lack of parent presence during appointments.
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Vitamin D and Cardio-Metabolic Risk Factors in Overweight Adults: An Overview of the Evidence.
Valer-Martinez, A, Martinez, JA, Sayon-Orea, C, Galvano, F, Grosso, G, Bes-Rastrollo, M
Current pharmaceutical design. 2019;(22):2407-2420
Abstract
BACKGROUND Several studies have suggested a potential association between low vitamin D serum levels and several pathological conditions apart from the well-known bone disorders. Thus, vitamin D insufficiency has been linked to cardiometabolic risk factors including obesity, insulin resistance, hypertension, dyslipidemia, as well as type 2 diabetes and cardiovascular disease. OBJECTIVE This review intends to provide an overview of recent evidence from clinical studies on vitamin D [25- hydroxyvitamin D (25(OH)D)] and cardiometabolic risk factors in overweight adults. Furthermore, we also discussed potential mechanisms and limits of the retrieved results. METHODS The search process was based on the selection of publications (RCT) listed in PubMed and Cochrane Library databases. RESULTS Vitamin D status evidenced an inversely strong association with subcutaneous adipose tissue and visceral adiposity, but not significantly related to other bodyweight measures (i.e., body mass index). Studies have shown a potential inverse association of hypovitaminosis D with insulin resistance and cardiovascular risk factors. CONCLUSION The mechanisms by which vitamin D deficiency enhances adiposity, as well as putative association with metabolic syndrome features, remain still unclear. Further investigation would be required to conclude whether vitamin D has an independent role in preventing cardiometabolic disorders.
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Protein Intake during the First Two Years of Life and Its Association with Growth and Risk of Overweight.
Tang, M
International journal of environmental research and public health. 2018;(8)
Abstract
Growth patterns early in life could exert a long-term impact on overweight and obesity development. Among all potential manipulative factors, infant diet is one of the most influential and could affect growth and subsequent health status during adolescence and adulthood. Dietary protein, as an important macronutrient in infants' diet, has been of special interest to researchers. Compared with human milk, infant formula tends to have a higher protein content and is associated with greater weight gain and later-in-life obesity risk. However, the effect of protein from other sources on infant growth trajectories during complementary feeding is not clear. Emerging research suggests that meat protein during early complementary feeding promotes linear growth while not increasing risk of overweight compared with dairy protein; and the gut microbiota might be a mediator between protein quality and growth trajectories. This review addresses the current knowledge of protein intake from birth to 24 months and its relationship with growth and risk of overweight.
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Is regular exercise an effective strategy for weight loss maintenance?
Foright, RM, Presby, DM, Sherk, VD, Kahn, D, Checkley, LA, Giles, ED, Bergouignan, A, Higgins, JA, Jackman, MR, Hill, JO, et al
Physiology & behavior. 2018;:86-93
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Weight regain after weight loss is one of the most significant challenges to successful obesity treatment. Regular exercise has long been touted as a strategy for weight loss maintenance, but the lack of clear evidence in clinical trials has caused some to question its effectiveness. In this review, we present the arguments both questioning and in support of exercise as an obesity therapeutic. Our purpose is to bring clarity to the literature, present a unified perspective, and identify the gaps in knowledge that need to be addressed in future studies. Critical questions remain including sex differences, individual variability and compensatory behaviors in response to exercise, exercise adherence, the role of energy flux and the molecular mechanisms mediating the beneficial effects of exercise after weight loss and during weight regain. Future research should focus on these critical questions to provide a more complete understanding of the potential benefits of exercise on weight loss maintenance.
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[Sociodemographic and lifestyle factors involved in excess weight].
Ortega, RM, Jiménez Ortega, AI, Perea Sánchez, JM, Peral Suárez, Á, López-Sobaler, AM
Nutricion hospitalaria. 2018;(Spec No6):25-29
Abstract
OBJECTIVES given the growing increase in overweight and obesity, it is important to pay attention to all sociodemographic and lifestyle influences that contribute to unbalance the energy balance, favoring this trend. METHODS bibliographic searching in relation to the subject. RESULTS as factors associated with the obesity condition, it is observed that sedentary lifestyle, scarce physical activity, passive leisure and a high number of hours in front of screens (TV, computer...) and reduction in the time spent sleeping. Moreover, low level of income and low educational level, favor excess weight, there being an additional association between these sociodemographic factors with non-compliance with the Dietary Guidelines and the gap of the diet from to what is marked as advisable. Particularly, spent a lot of time in front of a screen and a short duration of sleep are associated with more frequent consumption of foods with high energy density and few micronutrients and low consumption of fruits and vegetables. Specifically, in men and adjusting for age, it is observed that an insufficient intake of cereals (< 4 servings / day) and fruits and vegetables (< 5 servings / day) is associated with greater risk of overweight and of central adiposity, being remarkable the worst adherence to recommended dietary guidelines in individuals with excess weight and central adiposity. CONCLUSIONS strategies to prevent and reduce excess weight should consider these influences, which are associated and potentiated, in order to achieve more efficiency in the weight improvement of the population.
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Shift work, overweight and obesity in health professionals: a systematic review and meta-analysis.
Saulle, R, Bernardi, M, Chiarini, M, Backhaus, I, La Torre, G
La Clinica terapeutica. 2018;(4):e189-e197
Abstract
Shift work may have significant repercussions on the health of the worker, and has been linked to unhealthy lifestyles. The aim was to conduct a systematic review of the literature and to assess the relationship between night shift and overweight and obesity among health professionals. A literature search was performed using PubMed and Scopus. The keywords used included: "shift work", "night work", "obesity", "overweight", "nurses" "doctors" "physicians". The whole process of revision followed the PRISMA Statement. Two researchers independently, reviewed the search results, assessed the quality and extracted data. Six transversal and a cohort studies were found for the population of nurses. The meta-analysis did not produce significant results on the prevalence of obesity in the population of nurses (OR: 1.00; 95% CI 0.66-1.50). More high-quality studies and including a larger number of participants should be conducted, in order to assess whether there is real cause-effect relationship between the exposure to night shifts and weight gain as well as of obesity.
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Effect of educational interventions on health in childhood: A meta-analysis of randomized controlled trials.
Wang, X, Zhou, G, Zeng, J, Yang, T, Chen, J, Li, T
Medicine. 2018;(36):e11849
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Abstract
BACKGROUND The purpose of this study was to summarize the evidences from randomized controlled trials (RCTs) investigating the effects of educational interventions in overweight/obesity childhood by using meta-analytic approach. METHODS PubMed, Embase, and the Cochrane Library databases were searched from the inception to April 2018. Weighted mean differences (WMDs) with corresponding 95% confidence intervals (CIs) were used to measure the effects of educational interventions during childhood in the random-effects models. RESULTS Thirty RCTs reporting data on 35,296 children were included in the meta-analysis. The summary WMD indicated that children received educational interventions had lower levels of body mass index (BMI) (WMD: -0.15; 95% CI: -0.24 to -0.05; P = .003), BMI z-score (WMD: -0.03; 95% CI: -0.05 to -0.02; P < .001), waist circumference (WMD: -0.97; 95% CI: -1.95 to -0.00; P = 0.050), triceps skinfold (WMD: -1.39; 95% CI: -2.41 to -0.37; P = .008), systolic blood pressure (WMD: -1.13; 95% CI: -2.20 to -0.07; P = .037), total cholesterol (WMD: -4.04; 95% CI: -7.18 to -0.90; P = .012), and triglyceride (WMD: -2.62; 95% CI: -4.33 to -0.90; P = .003). However, educational interventions were not associated with the levels of waist-to-hip ratio, diastolic blood pressure, high-density lipoprotein, and low-density lipoprotein. CONCLUSION The study findings elucidate the positive effects of educational interventions on BMI, BMI z-score, waist circumference, triceps skinfold, systolic blood pressure, total cholesterol, and triglyceride.