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1.
Current methods and prospects of coronavirus detection.
Bu, J, Deng, Z, Liu, H, Li, J, Wang, D, Yang, Y, Zhong, S
Talanta. 2021;:121977
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Abstract
SARS-COV-2 is a novel coronavirus discovered in Wuhan in December 30, 2019, and is a family of SARS-COV (severe acute respiratory syndrome coronavirus), that is, coronavirus family. After infection with SARS-COV-2, patients often experience fever, cough, gas prostration, dyspnea and other symptoms, which can lead to severe acute respiratory syndrome (SARS), kidney failure and even death. The SARS-COV-2 virus is particularly infectious and has led to a global infection crisis, with an explosion in the number of infections. Therefore, rapid and accurate detection of the virus plays a vital role. At present, many detection methods are limited in their wide application due to their defects such as high preparation cost, poor stability and complex operation process. Moreover, some methods need to be operated by professional medical staff, which can easily lead to infection. In order to overcome these problems, a Surface molecular imprinting technology (SM-MIT) is proposed for the first time to detect SARS-COV-2 virus. For this SM-MIT method, this review provides detailed detection principles and steps. In addition, this method not only has the advantages of low cost, high stability and good specificity, but also can detect whether it is infected at designated points. Therefore, we think SM-MIT may have great potential in the detection of SARS-COV-2 virus.
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2.
How Can a Polymeric Formula Induce Remission in Crohn's Disease Patients?
Boumessid, K, Barreau, F, Mas, E
International journal of molecular sciences. 2021;(8)
Abstract
Crohn's disease is an inflammatory bowel disease whose prevalence is increasing worldwide. Among medical strategies, dietary therapy with exclusive enteral nutrition is recommended as a first-line option, at least for children, because it induces clinical remission and mucosal healing. Modulen®, a polymeric TGF-β2 enriched formula, has good palatability and is widely used. For the first time in the literature, this review outlines and discusses the clinical outcomes obtained with this therapy, as well as the potential mechanisms of action of its compounds. It can be explained by its TGF-β2 content, but also by its protein and lipid composition. Further well-designed studies are required to improve our knowledge and to optimize therapeutic strategies.
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3.
From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances.
Skopinska-Wisniewska, J, De la Flor, S, Kozlowska, J
International journal of molecular sciences. 2021;(14)
Abstract
Supramolecular hydrogels are 3D, elastic, water-swelled materials that are held together by reversible, non-covalent interactions, such as hydrogen bonds, hydrophobic, ionic, host-guest interactions, and metal-ligand coordination. These interactions determine the hydrogels' unique properties: mechanical strength; stretchability; injectability; ability to self-heal; shear-thinning; and sensitivity to stimuli, e.g., pH, temperature, the presence of ions, and other chemical substances. For this reason, supramolecular hydrogels have attracted considerable attention as carriers for active substance delivery systems. In this paper, we focused on the various types of non-covalent interactions. The hydrogen bonds, hydrophobic, ionic, coordination, and host-guest interactions between hydrogel components have been described. We also provided an overview of the recent studies on supramolecular hydrogel applications, such as cancer therapy, anti-inflammatory gels, antimicrobial activity, controlled gene drug delivery, and tissue engineering.
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4.
Did Cyclic Metaphosphates Have a Role in the Origin of Life?
Glonek, T
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 2021;(1):1-60
Abstract
How life began still eludes science life, the initial progenote in the context presented herein, being a chemical aggregate of primordial inorganic and organic molecules capable of self-replication and evolution into ever increasingly complex forms and functions.Presented is a hypothesis that a mineral scaffold generated by geological processes and containing polymerized phosphate units was present in primordial seas that provided the initiating factor responsible for the sequestration and organization of primordial life's constituents. Unlike previous hypotheses proposing phosphates as the essential initiating factor, the key phosphate described here is not a polynucleotide or just any condensed phosphate but a large (in the range of at least 1 kilo-phosphate subunits), water soluble, cyclic metaphosphate, which is a closed loop chain of polymerized inorganic phosphate residues containing only phosphate middle groups. The chain forms an intrinsic 4-phosphate helix analogous to its structure in Na Kurrol's salt, and as with DNA, very large metaphosphates may fold into hairpin structures. Using a Holliday-junction-like scrambling mechanism, also analogous to DNA, rings may be manipulated (increased, decreased, exchanged) easily with little to no need for additional energy, the reaction being essentially an isomerization.A literature review is presented describing findings that support the above hypothesis. Reviewed is condensed phosphate inorganic chemistry including its geological origins, biological occurrence, enzymes and their genetics through eukaryotes, polyphosphate functions, circular polynucleotides and the role of the Holliday junction, previous biogenesis hypotheses, and an Eoarchean Era timeline.
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5.
Recent advances of thermal properties of sugar palm lignocellulosic fibre reinforced polymer composites.
Asyraf, MRM, Ishak, MR, Norrrahim, MNF, Nurazzi, NM, Shazleen, SS, Ilyas, RA, Rafidah, M, Razman, MR
International journal of biological macromolecules. 2021;(Pt B):1587-1599
Abstract
Biocomposites are materials that are easy to manufacture and environmentally friendly. Sugar palm fibre (SPF) is considered to be an emerging reinforcement candidate that could provide improved mechanical stiffness and strength to the biocomposites. Numerous studies have been recently conducted on sugar palm biocomposites to evaluate their physical, mechanical and thermal properties in various conditions. Sugar palm biocomposites are currently limited to the applications of traditional household products despite their good thermal stability as a prospective substitute candidate for synthetic fibres. Thus, thermal analysis methods such as TGA and DTG are functioned to determine the thermal properties of single fibre sugar palm composites (SPCs) in thermoset and thermoplastic matrix as well as hybrid SPCs. The biocomposites showed a remarkable change considering thermal stability by varying the individual fibre compositions and surface treatments and adding fillers and coupling agents. However, literature that summarises the thermal properties of sugar palm biocomposites is unavailable. Particularly, this comprehensive review paper aims to guide all composite engineers, designers, manufacturers and users on the selection of suitable biopolymers for sugar palm biocomposites for thermal applications, such as heat shields and engine components.
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6.
Metal Sulfide Semiconductor Nanomaterials and Polymer Microgels for Biomedical Applications.
Paca, AM, Ajibade, PA
International journal of molecular sciences. 2021;(22)
Abstract
The development of nanomaterials with therapeutic and/or diagnostic properties has been an active area of research in biomedical sciences over the past decade. Nanomaterials have been identified as significant medical tools with potential therapeutic and diagnostic capabilities that are practically impossible to accomplish using larger molecules or bulk materials. Fabrication of nanomaterials is the most effective platform to engineer therapeutic agents and delivery systems for the treatment of cancer. This is mostly due to the high selectivity of nanomaterials for cancerous cells, which is attributable to the porous morphology of tumour cells which allows nanomaterials to accumulate more in tumour cells more than in normal cells. Nanomaterials can be used as potential drug delivery systems since they exist in similar scale as proteins. The unique properties of nanomaterials have drawn a lot of interest from researchers in search of new chemotherapeutic treatment for cancer. Metal sulfide nanomaterials have emerged as the most used frameworks in the past decade, but they tend to aggregate because of their high surface energy which triggers the thermodynamically favoured interaction. Stabilizing agents such as polymer and microgels have been utilized to inhibit the particles from any aggregations. In this review, we explore the development of metal sulfide polymer/microgel nanocomposites as therapeutic agents against cancerous cells.
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7.
A review on Borassus flabellifer lignocellulose fiber reinforced polymer composites.
Singh, JK, Rout, AK, Kumari, K
Carbohydrate polymers. 2021;:117929
Abstract
Natural fiber composites play an important role for developing high performance engineering materials due to its facile availability, recyclability and eco-friendly nature. Borassus flabellifer products are significant and economical for urban and rural areas, and its fruit, leaf stalk and leaves are used in domestic purposes and some of them are disposed as waste. This waste part of Borassus flabellifer serves as a potential resource for natural fibers and utilized as raw material for reinforced polymer composites. The aim of this article narrates a comprehensive overview of Borassus fibers and its composites. Alkali treatment techniques, different fabrication methods, preparation of different matrices reinforced with bio-fibers and chemical, mechanical, thermal, morphological properties of Borassus fibers and its composites have been studied. Overall, this review article highlights, investigates and identifies gaps of the earlier research work, and provides the resourceful data for future work in various streams with Borassus fiber as reinforcement.
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8.
Cutaneous Polymer-Coating Embolism After Endovascular Procedures: Report of Two Cases and a Literature Review.
Berríos-Hernández, M, Abou-Jokh Casas, C, Sainz-Gaspar, L, Ginarte-Val, J, Fernández Redondo, V, López-Otero, D, Aliste, C, Suárez-Peñaranda, JM
The American Journal of dermatopathology. 2021;(9):662-666
Abstract
Different hydrophilic and hydrophobic polymers are used as lubricious coatings to reduce vascular traumas in minimally invasive percutaneous procedures. Although they are usually very safe, there is still a risk of serious complications in patients undergoing such procedures, mostly derived from the devices' coating detachment and systemic embolization. The lungs are the most common organ involved, followed by the central nervous system. Yet, cutaneous embolization is unusual, and only 19 cases are available in the literature. Most commonly, they present as asymptomatic retiform purpura on the lower legs, which tends to involve spontaneously. Correct clinical diagnosis is not suspected in most cases, being cholesterol emboly or vasculitis the preferred options. Time interval since surgical procedure and appearance of lesions vary widely but they generally start in the first few days. Histopathological identification of the embolus as bluish, amorphous intraluminal material in dermal vessels is diagnostic, but vasculitic signs are not present. We report 2 cases of skin lesions as the main manifestation of polymer embolization after endovascular surgical procedures. In both cases, biopsy allowed identification of embolized foreign material and lesions resolved without specific treatment.
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9.
Production of polymers by cyanobacteria grown in wastewater: Current status, challenges and future perspectives.
Arias, DM, García, J, Uggetti, E
New biotechnology. 2020;:46-57
Abstract
Cyanobacteria are prokaryotic oxygenic phototrophs receiving attention in a wide variety of technological applications such as food and feed supplements and production of valuable polymers. Among these, carbohydrates (e.g. glycogen) and polyhydroxyalkanoates (PHAs) are of increasing interest due to their potential as a biofuel substrate and bioplastics, respectively. However, biofuels and bioplastics from cyanobacteria have seen many years of effort towards commercialization with only limited success. Their main limitation for polymer production is the high cost of the nutrient source; wastewater, as an inexpensive and widely available alternative, may overcome this bottleneck. Though cyanobacteria have demonstrated a capacity to treat wastewater effluents, their cultivation in such a variable environment involves certain challenges of which the chief one is linked to contamination by other species, especially green algae. This would represent a serious drawback during cyanobacterial biomass production and affect further PHA and carbohydrate production. The present study reviews the potential of cyanobacteria to grow in wastewater effluents from different sources. Conditions favoring them in mixed-culture reactors are described, focusing on nutritional and operational aspects. Current advances and future prospects in PHA and carbohydrate production are explored and discussed.
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10.
Review of Chitosan-Based Polymers as Proton Exchange Membranes and Roles of Chitosan-Supported Ionic Liquids.
Rosli, NAH, Loh, KS, Wong, WY, Yunus, RM, Lee, TK, Ahmad, A, Chong, ST
International journal of molecular sciences. 2020;(2)
Abstract
Perfluorosulphonic acid-based membranes such as Nafion are widely used in fuel cell applications. However, these membranes have several drawbacks, including high expense, non-eco-friendliness, and low proton conductivity under anhydrous conditions. Biopolymer-based membranes, such as chitosan (CS), cellulose, and carrageenan, are popular. They have been introduced and are being studied as alternative materials for enhancing fuel cell performance, because they are environmentally friendly and economical. Modifications that will enhance the proton conductivity of biopolymer-based membranes have been performed. Ionic liquids, which are good electrolytes, are studied for their potential to improve the ionic conductivity and thermal stability of fuel cell applications. This review summarizes the development and evolution of CS biopolymer-based membranes and ionic liquids in fuel cell applications over the past decade. It also focuses on the improved performances of fuel cell applications using biopolymer-based membranes and ionic liquids as promising clean energy.