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Differences in lumbar spine and lower extremity kinematics in people with and without low back pain during a step-up task: a cross-sectional study.
Mitchell, K, Porter, M, Anderson, L, Phillips, C, Arceo, G, Montz, B, Levy, S, Gombatto, SP
BMC musculoskeletal disorders. 2017;(1):369
Abstract
BACKGROUND Low back pain (LBP) affects more than one third of the population at any given time, and chronic LBP is responsible for increased medical costs, functional limitations and decreased quality of life. A clear etiology is often difficult to identify, but aberrant posture and movement are considered contributing factors to chronic LBP that are addressed during physiotherapy intervention. Information about aberrant movement during functional activities in people with LBP can help inform more effective interventions. The purpose of this study was to determine if there are differences in lumbar spine and lower extremity kinematics in people with and without LBP during a step-up task. METHODS A convenience sample of 37 participants included 19 with LBP and 18 without a history of LBP. All participants were between the ages of 18 and 65, and controls were matched to participants with LBP based on age, gender and BMI. A motion capture system was used to record spine and lower extremity kinematics during the step-up task. ANOVA tests were used to determine differences in three-dimensional kinematics between groups. RESULTS Participants with LBP displayed less lower lumbar motion in the sagittal plane (P = 0.001), more knee motion in the coronal plane (P = 0.001), and more lower extremity motion in the axial plane (P = 0.002) than controls. CONCLUSIONS People with LBP display less lower lumbar spine motion in the sagittal plane and more out-of-plane lower extremity motion. Clinically, the step-up task can be used to identify these aberrant movements to develop more focused functional interventions for patients with LBP. TRIAL REGISTRATION Not applicable.
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Effect of resistance training using bodyweight in the elderly: Comparison of resistance exercise movement between slow and normal speed movement.
Watanabe, Y, Tanimoto, M, Oba, N, Sanada, K, Miyachi, M, Ishii, N
Geriatrics & gerontology international. 2015;(12):1270-7
Abstract
AIM: The present study investigated whether a slow movement protocol can be applied to resistance training using bodyweight. In addition, the intervention program combined plyometric exercise with resistance exercise to improve physical function overall. METHODS A total of 39 active elderly adults participated in a 16-week intervention. The program consisted of five resistance exercises and four plyometric exercises using their own bodyweight with a single set for each exercise. Participants were assigned to one of two experimental groups. One group carried out resistance exercise with slow movement and tonic force generation (3-s concentric, 3-s eccentric and 1-s isometric actions with no rest between each repetition). The other group as a movement comparison followed the same regimen, but at normal speed (1-s eccentric and 1-s concentric actions with 1-s rest between each repetition). Muscle size, strength and physical function were measured before and after the intervention period. RESULTS After the intervention, strengths of upper and lower limbs, and maximum leg extensor power were significantly improved in both groups. Muscle size did not change in either group. There were no significant differences in any of the parameters between groups. CONCLUSIONS The intervention program using only own bodyweight that comprised resistance exercise with slow movement and plyometric exercise can improve physical function in the elderly, even with single sets for each exercise. However, there was no enhanced muscle hypertrophic effect. Further attempts, such as increasing performing multiple sets, would be required to induce muscle hypertrophy. Geriatr Gerontol Int 2015; 15: 1270-1277.
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Comparison of randomized preemptive dexketoprofen trometamol or placebo tablets to prevent withdrawal movement caused by rocuronium injection.
Aydın, GB, Polat, R, Ergil, J, Sayın, M, Caparlar, CO
Journal of anesthesia. 2014;(3):471-4
Abstract
Rocuronium is a non-depolarizing neuromuscular blocking agent which is associated with injection pain and induces withdrawal movement of the injected hand or arm or generalized movements of the body after intravenous injection. The aim of this randomized study was to compare the efficacy of pretreatment with oral dexketoprofen trometamol (Arvelles(®); Group A) with placebo (Group P) without tourniquet to prevent the withdrawal response caused by rocuronium injection. The study cohort comprised 150 American Society of Anaesthesiologists class I-III patients aged 18-75 years who were scheduled to undergo elective surgery with general anesthesia. The patients response to rocuronium was graded using a 4-point scale [0 = no response; 1 = movement/withdrawal at the wrist only, 2 = movement/withdrawal involving the arm only (elbow/shoulder); 3 = generalized response]. The overall incidence of withdrawal movement after rocuronium injection was significantly lower in Group A (30.1 %) than in Group P (64.6 %) (p < 0.001). The incidence of score 0 withdrawal movements was higher in Group A (69.9 %) than in Group P (35.4 %), that of score 1 withdrawal movements was similar between groups (Group A 21.9 %; Group B 26.1 %) (p = 0.560) and that of score 2 withdrawal movements was lower in Group A (8.2 %) than in Group P (38.5 %) (p < 0.001). There were no score 3 withdrawal movements in either group (p > 0.05). These results demonstrate that the preemptive administration of dexketoprofen trometamol can attenuate the degree of withdrawal movements caused by the pain of the rocuronium injection.
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Combined measures of movement and force variability distinguish Parkinson's disease from essential tremor.
Poon, C, Robichaud, JA, Corcos, DM, Goldman, JG, Vaillancourt, DE
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2011;(11):2268-75
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Abstract
OBJECTIVE To examine whether behavioral and electrophysiological measures of motor performance accurately differentiate Parkinson's disease (PD) and essential tremor (ET). METHODS Twenty-four patients (12 PD; 12 ET) performed isometric force, ballistic movements, and tremor tasks. Receiver operating characteristic (ROC) analyses were conducted on all dependent measures that were significantly different between the two patient groups. RESULTS Patients with PD were more impaired on measures of movement deceleration than ET. Patients with ET were more impaired on measures of force variability than PD. ROC analyses revealed that sensitivity and specificity were excellent when combining measures during the isometric force task (torque rise time and force variability; 92% sensitivity and 92% specificity; AUC = 0.97). When combining measures across the force and movement tasks, the ROC analysis revealed improved sensitivity and specificity (force variability and peak deceleration; 92% sensitivity and 100% specificity; AUC = 0.99). CONCLUSIONS Combining measures of force variability and movement deceleration accurately differentiate patients with PD from those with ET with high sensitivity and specificity. SIGNIFICANCE If validated in a larger sample, these measures can serve as markers to confirm the diagnosis of PD or ET and thus, enhance decision making for appropriate treatments for patients with these respective diseases.
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Analysis of the 5 iron golf swing when hitting for maximum distance.
Healy, A, Moran, KA, Dickson, J, Hurley, C, Smeaton, AF, O'Connor, NE, Kelly, P, Haahr, M, Chockalingam, N
Journal of sports sciences. 2011;(10):1079-88
Abstract
Most previous research on golf swing mechanics has focused on the driver club. The aim of this study was to identify the kinematic factors that contribute to greater hitting distance when using the 5 iron club. Three-dimensional marker coordinate data were collected (250 Hz) to calculate joint kinematics at eight key swing events, while a swing analyser measured club swing and ball launch characteristics. Thirty male participants were assigned to one of two groups, based on their ball launch speed (high: 52.9 ± 2.1 m · s(-1); low: 39.9 ± 5.2 m · s(-1)). Statistical analyses were used to identify variables that differed significantly between the two groups. Results showed significant differences were evident between the two groups for club face impact point and a number of joint angles and angular velocities, with greater shoulder flexion and less left shoulder internal rotation in the backswing, greater extension angular velocity in both shoulders at early downswing, greater left shoulder adduction angular velocity at ball contact, greater hip joint movement and X Factor angle during the downswing, and greater left elbow extension early in the downswing appearing to contribute to greater hitting distance with the 5 iron club.
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Once-weekly dose of 8400 IU vitamin D(3) compared with placebo: effects on neuromuscular function and tolerability in older adults with vitamin D insufficiency.
Lips, P, Binkley, N, Pfeifer, M, Recker, R, Samanta, S, Cohn, DA, Chandler, J, Rosenberg, E, Papanicolaou, DA
The American journal of clinical nutrition. 2010;(4):985-91
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Abstract
BACKGROUND Vitamin D insufficiency, which is prevalent in older individuals, is associated with bone and muscle weakness and falls. OBJECTIVE We examined the effects of a weekly dose of 8400 IU vitamin D(3) on postural stability, muscle strength, and safety. DESIGN In this double-blind trial, subjects aged > or =70 y with serum 25-hydroxyvitamin D [25(OH)D] concentrations < or =20 but > or =6 ng/mL were randomly assigned to receive a weekly dose of 8400 IU vitamin D(3) (n = 114) or a placebo (n = 112). Mediolateral body sway with eyes open (assessed with the AccuSway(PLUS) platform; Advanced Medical Technology Inc, Watertown, MA) was the primary endpoint. Secondary endpoints included the short physical performance battery (SPPB) and serum 25(OH)D concentrations. An analysis of covariance model was used for treatment comparisons. Safety and tolerability were monitored. RESULTS Serum 25(OH)D concentrations rose significantly (from 13.9 to 26.2 ng/mL, P < 0.001) in patients treated with 8400 IU vitamin D(3) but not in patients treated with the placebo. After 16 wk, neither mediolateral sway nor SPPB differed significantly between treatment groups. However, in the post hoc analysis of patients subgrouped by baseline sway (> or = 0.46 compared with <0.46 cm), treatment with 8400 IU vitamin D(3) significantly reduced sway compared with treatment with placebo (P = 0.047) in patients with elevated baseline sway but not in patients with normal baseline sway. Adverse experiences and incidences of hypercalcemia, hypercalciuria, and elevated creatinine were similar with both treatments. In patients treated with 8400 IU vitamin D(3), but not in placebo-treated patients, parathyroid hormone decreased significantly. CONCLUSIONS Weekly treatment with 8400 IU vitamin D(3) raised 25(OH)D concentrations in elderly, vitamin D-insufficient individuals. Treatment with 8400 IU vitamin D(3) did not reduce mediolateral sway significantly compared with treatment with placebo in this population, although in post hoc analysis, treatment with 8400 IU vitamin D(3) reduced sway in the subgroup of patients who had elevated sway at baseline. Weekly treatment with 8400 IU vitamin D(3) was well tolerated. This trial was registered at clinicaltrials.gov as NCT00242476.
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Temperature and pyoverdine-mediated iron acquisition control surface motility of Pseudomonas putida.
Matilla, MA, Ramos, JL, Duque, E, de Dios Alché, J, Espinosa-Urgel, M, Ramos-González, MI
Environmental microbiology. 2007;(7):1842-50
Abstract
Pseudomonas putida KT2440 is unable to swarm at its common temperature of growth in the laboratory (30 degrees C) but exhibits surface motility similar to swarming patterns in other Pseudomonas between 18 degrees C and 28 degrees C. These motile cells show differentiation, consisting on elongation and the presence of surface appendages. Analysis of a collection of mutants to define the molecular determinants of this type of surface movement in KT2440 shows that while type IV pili and lipopolysaccharide O-antigen are requisites flagella are not. Although surface motility of flagellar mutants was macroscopically undistinguishable from that of the wild type, microscopy analysis revealed that these mutants move using a distinct mechanism to that of the wild-type strain. Mutants either in the siderophore pyoverdine (ppsD) or in the FpvA siderophore receptor were also unable to spread on surfaces. Motility in the ppsD strain was totally restored with pyoverdine and partially with the wild-type ppsD allele. Phenotype of the fpvA strain was not complemented by this siderophore. We discuss that iron influences surface motility and that it can be an environmental cue for swarming-like movement in P. putida. This study constitutes the first report assigning an important role to pyoverdine iron acquisition in en masse bacterial surface movement.
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A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans.
Huppert, TJ, Hoge, RD, Diamond, SG, Franceschini, MA, Boas, DA
NeuroImage. 2006;(2):368-82
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Abstract
In this study, we have preformed simultaneous near-infrared spectroscopy (NIRS) along with BOLD (blood oxygen level dependent) and ASL (arterial spin labeling)-based fMRI during an event-related motor activity in human subjects in order to compare the temporal dynamics of the hemodynamic responses recorded in each method. These measurements have allowed us to examine the validity of the biophysical models underlying each modality and, as a result, gain greater insight into the hemodynamic responses to neuronal activation. Although prior studies have examined the relationships between these two methodologies through similar experiments, they have produced conflicting results in the literature for a variety of reasons. Here, by employing a short-duration, event-related motor task, we have been able to emphasize the subtle temporal differences between the hemodynamic parameters with a high contrast-to-noise ratio. As a result of this improved experimental design, we are able to report that the fMRI measured BOLD response is more correlated with the NIRS measure of deoxy-hemoglobin (R = 0.98; P < 10(-20)) than with oxy-hemoglobin (R = 0.71), or total hemoglobin (R = 0.53). This result was predicted from the theoretical grounds of the BOLD response and is in agreement with several previous works [Toronov, V.A.W., Choi, J.H., Wolf, M., Michalos, A., Gratton, E., Hueber, D., 2001. "Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging." Med. Phys. 28 (4) 521-527.; MacIntosh, B.J., Klassen, L.M., Menon, R.S., 2003. "Transient hemodynamics during a breath hold challenge in a two part functional imaging study with simultaneous near-infrared spectroscopy in adult humans". NeuroImage 20 1246-1252.; Toronov, V.A.W., Walker, S., Gupta, R., Choi, J.H., Gratton, E., Hueber, D., Webb, A., 2003. "The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal" Neuroimage 19 (4) 1521-1531]. These data have also allowed us to examine more detailed measurement models of the fMRI signal and comment on the roles of the oxygen saturation and blood volume contributions to the BOLD response. In addition, we found high correlation between the NIRS measured total hemoglobin and ASL measured cerebral blood flow (R = 0.91; P < 10(-10)) and oxy-hemoglobin with flow (R = 0.83; P < 10(-05)) as predicted by the biophysical models. Finally, we note a significant amount of cross-modality, correlated, inter-subject variability in amplitude change and time-to-peak of the hemodynamic response. The observed co-variance in these parameters between subjects is in agreement with hemodynamic models and provides further support that fMRI and NIRS have similar vascular sensitivity.
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Repeated maximal eccentric actions causes long-lasting disturbances in movement control.
Bottas, R, Linnamo, V, Nicol, C, Komi, PV
European journal of applied physiology. 2005;(1-2):62-9
Abstract
This study examined acute and long-lasting effects of fatigue and muscle damage on fast and accurate elbow flexion and extension target movements (TM) with eight male students. An isokinetic machine was used to perform 100 maximal eccentric and concentric elbow flexions at 4-week intervals. Movement range was 40-170 degrees in eccentric exercise (ECCE) and 170-40 degrees in concentric exercise (CONE), with an angular velocity of 2 rad s(-1). TM was performed in sitting position with the right forearm fixed to lever arm above protractor. Subjects performed TM in horizontal plane (amplitude 60 degrees ) by visual feedback of movement from a television monitor. Surface EMG was recorded from the biceps brachii and triceps brachii muscles. TM measurements and serum creatine kinase (CK) determinations were conducted before, after, 0.5 h, 2 days, and 7 days after both exercises. Blood lactate was taken before, after, and 0.5 h after the exercises. Both ECCE and CONE led to a large decline in maximal voluntary contractions, but the recovery was slower after ECCE when it remained incomplete even until day 7 post-exercise. Lactate increased (P < 0.001) similarly after both exercises. Delayed-onset muscle soreness peaked on day 2 and CK peaked on day 7 after ECCE. Exhaustive eccentric exercise of agonistic muscles impaired the flexion TM performance, and had a long-duration modulation effect on the triphasic EMG activity pattern of flexion and extension TM. In the acute phase, the observed changes in performance and in the EMG patterns are suggested to be related to metabolic changes via III and IV muscle afferents. The delayed recovery, on the other hand, may be related to problems in the proprioceptive feedback caused by muscle damage.
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Fractal analysis of acceleration signals from patients with CPPD, rheumatoid arthritis, and spondyloarthroparthy of the finger joint.
Shah, EN, Reddy, NP, Rothschild, BM
Computer methods and programs in biomedicine. 2005;(3):233-9
Abstract
Arthritis is one of the leading causes of disability and affects a major segment of the population. Consequently, accurate diagnosis of arthritis is important. Arthritis due to calcium pyrophosphate deposition disease (CPPD), rheumatoid arthritis, and spondyloarthropathy, induce complex changes in the cartilage and the articular surface. The fractal dimension provides a measure of the complexity of a signal. Recently, we have developed non-invasive acceleration measurements to characterize the arthritic patients. The question remains if the fractal dimension of the acceleration signal is different for different arthritis conditions. The purpose of this study was to distinguish between different types of arthritis of the finger joint using the fractal dimension of the acceleration signal obtained from the finger joint of the arthritic patients. Acceleration signals were obtained from the finger joint of arthritis patients with rheumatoid arthritis, spondyloarthropathy, and calcium pyrophosphate deposition disease of the finger joint. ANOVA results showed that there were significant differences between the fractal dimension of acceleration signals from patients having calcium pyrophosphate deposition disease and rheumatoid arthritis and spondyloarthropathy. Fractal dimension of acceleration signals, in concert with other clinical symptoms, can be used to classify different types of arthritis.