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Validity and reliability of the measure yourself medical outcome profile 2 (MYMOP2) questionnaire among Turkish patients having anorectal disorders.
Ersoy, Ö, Temel, YE, Alptekin, HK
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2019;30(1):28-32
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The MYMOP (Measure Yourself Medical Outcome Profile) questionnaire allows patients to select up to two symptoms that concern them most, and to subjectively assess the change of these symptoms over time following a therapeutic intervention. The aim of this study was to translate the MYMOP2 questionnaire into Turkish and add this questionnaire into Turkish medical practice and culture and assess its validity and reliability among the patients with anorectal disorders - medical disorders that occur at the junction of the anal canal and the rectum - (chronic constipation, anal incontinence, chronic pelvic pain). The MYMOP2 consists of four questions. All questions have to be rated on 7-point Likert-type scales. The study included fifty-seven patients who presented anorectal disorders. The MYMOP2 was compared to the NHP (Nottingham Health Profile) to test its construct validity. Results indicate that the Turkish version of the MYMOP2 proved to be both valid and reliable. Authors conclude that since the Turkish version of MYMOP2 is short and simple to fill-in, it can be easily incorporated into many health care, as well as gastroenterology, settings. It might be an important tool to enhance patient-centred care.
Abstract
BACKGROUND/AIMS: Measure Yourself Medical Outcome Profile 2 (MYMOP2) is a patient-generated outcome measure allowing patients to select the problems that are the most important to them and that they want to address, and it measures the effects of the problem from a wide range of health care interventions. This study aimed to translate the questionnaire into Turkish language (Turkish MYMOP-TMYMOP) and add this clinically useful measure to Turkish medical practice by assessing its validity and reliability. MATERIALS AND METHODS Fifty volunteers with anorectal disorders were prospectively included into the study. Each patient was enrolled into a pelvic floor training biofeedback program, specific to their anorectal symptomatology. The subjects were administered both the Nottingham Health Profile and the TMYMOP2 questionnaires before the treatment session (initial visit) and at the control follow-up visits (the first and second months, via e-mail or telephone calls). RESULTS The TMYMOP2 questionnaire was shown to be moderately valid (the Pearson correlation coefficient score between the total scores of the subgroups of the two questionnaires were 0.335 and 0.642, respectively, p<0.05) and highly reliable (the Cronbach's alfa coefficient score between the total scores of the subgroups of the two questionnaires were 0.77, 0.82, and 0.88 in the beginning and at the first and second month follow-up visits, respectively). CONCLUSION The TMYMOP2 was shown to be a low-to-moderately valid and a highly reliable scale. Because it is brief and short to complete, it might be an important and free-to-use tool to measure the diseases, and it can enhance the patient-centered care within the Turkish health care context.
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Alterations in Enteric Virome Are Associated With Colorectal Cancer and Survival Outcomes.
Nakatsu, G, Zhou, H, Wu, WKK, Wong, SH, Coker, OO, Dai, Z, Li, X, Szeto, CH, Sugimura, N, Lam, TY, et al
Gastroenterology. 2018;155(2):529-541.e5
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Whilst research shows that patients with colorectal cancer (CRC) have a different microbiome composition to those without, little is known about differences in the virome, the collection of viruses in and on the human body. The authors investigated the viromes of faecal samples of patients with CRC and found that the gut virome differed between CRC patients and controls. Differences were also seen between early and late stage CRC patients, and certain virome profiles were associated with disease prognosis. The authors conclude that these virome “signatures” associated with CRC may be used for diagnostic purposes and to predict outcomes.
Abstract
BACKGROUND & AIMS Patients with colorectal cancer (CRC) have a different gut microbiome signature than individuals without CRC. Little is known about the viral component of CRC-associated microbiome. We aimed to identify and validate viral taxonomic markers of CRC that might be used in detection of the disease or predicting outcome. METHODS We performed shotgun metagenomic analyses of viromes of fecal samples from 74 patients with CRC (cases) and 92 individuals without CRC (controls) in Hong Kong (discovery cohort). Viral sequences were classified by taxonomic alignment against an integrated microbial reference genome database. Viral markers associated with CRC were validated using fecal samples from 3 separate cohorts: 111 patients with CRC and 112 controls in Hong Kong, 46 patients with CRC and 63 controls in Austria, and 91 patients with CRC and 66 controls in France and Germany. Using abundance profiles of CRC-associated virome genera, we constructed random survival forest models to identify those associated with patient survival times. RESULTS The diversity of the gut bacteriophage community was significantly increased in patients with CRC compared with controls. Twenty-two viral taxa discriminated cases from controls with an area under the receiver operating characteristic curve of 0.802 in the discovery cohort. The viral markers were validated in 3 cohorts, with area under the receiver operating characteristic curves of 0.763, 0.736, and 0.715, respectively. Clinical subgroup analysis showed that dysbiosis of the gut virome was associated with early- and late-stage CRC. A combination of 4 taxonomic markers associated with reduced survival of patients with CRC (log-rank test, P = 8.1 × 10-6) independently of tumor stage, lymph node metastases, or clinical parameters. We found altered interactions between bacteriophages and oral bacterial commensals in fecal samples from patients with CRC compared with controls. CONCLUSIONS In a metagenomic analysis of fecal samples from patients and controls, we identified virome signatures associated with CRC. These data might be used to develop tools to identify individuals with CRC or predict outcomes.