Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial.

I-Ju Chen, Chia-Yu Liu, Jung-Peng Chiu, Chung-Hua Hsu

Journal: Clinical nutrition (Edinburgh, Scotland) 2018;35(3):592-9

PMID: 26093535

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND AND AIMS

To examine the effect and safety of high-dose green tea extract (Epigallocatechin gallate, EGCG) at a daily dosage of 856.8 mg on weight reduction and changes of lipid profile and obesity-related hormone peptides in women with central obesity.

METHODS

We conducted a randomized, double-blind trial registered under ClinicalTrials.gov Identifier no. NCT02147041. A total of 115 women with central obesity were screened at our clinic. 102 of them with a body mass index (BMI) ≥ 27 kg/m(2) and a waist circumference (WC) ≥ 80 cm were eligible for the study. These women were randomly assigned to either a high-dose green tea group or placebo group. The total treatment time was 12 weeks. The main outcome measures were anthropometric measurements, lipid profiles, and obesity related hormone peptides including leptin, adiponectin, ghrelin, and insulin.

RESULTS

Significant weight loss, from 76.8 ± 11.3 kg to 75.7 ± 11.5 kg (p = 0.025), as well as decreases in BMI (p = 0.018) and waist circumference (p = 0.023) were observed in the treatment group after 12 weeks of high-dose EGCG treatment. This study also demonstrated a consistent trend of decreased total cholesterol, reaching 5.33%, and decreased LDL plasma levels. There was good tolerance of the treatment among subjects without any side effects or adverse events. Significantly lower ghrelin levels and elevated adiponectin levels were detected in the study group than in the placebo group.

CONCLUSION

12 weeks of treatment with high-dose green tea extract resulted in significant weight loss, reduced waist circumference, and a consistent decrease in total cholesterol and LDL plasma levels without any side effects or adverse effects in women with central obesity. The antiobestic mechanism of high-dose green tea extract might be associated in part with ghrelin secretion inhibition, leading to increased adiponectin levels.

Address: Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taiwan; Taiwan International Traditional Chinese Medicine Training Center, Taipei, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.; Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taiwan; Taiwan International Traditional Chinese Medicine Training Center, Taipei, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: [email protected].

DOI: 10.1016/j.clnu.2015.05.003

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MeSH Terms: Adult, Anti-Obesity Agents, Body Mass Index, Camellia sinensis, Catechin, Dietary Supplements, Double-Blind Method, Female, Food Preservation, Ghrelin, Humans, Hyperlipidemias, Hypolipidemic Agents, Middle Aged, Obesity, Abdominal, Oxidation-Reduction, Patient Dropouts, Plant Extracts, Plant Leaves, Taiwan, Waist Circumference, Weight Loss