Eating habits not only affect current health but may determine the development of future diseases in later stages of life. The appearance of genomics has presented an opportunity to explore the inter-individual differences in the metabolism of and response to nutrients. Nutraceuticals are biological substances extracted from natural sources by non-denaturing processes to preserve their original properties without any chemical manipulation. Thus, non-denaturation conditions and the use of the original matrix of the species allow all health-beneficial properties to remain intact. This review outlines that: - fish occupies the highest position in marine animal consumption. Literature shows strong links between fish and seafood consumption and positive health effects, particularly in a decreased risk of coronary heart and cardiovascular diseases, a decrease in inflammatory diseases such as arthritis, and the prevention of cancer. - the consumption of complex marine extracts provides numerous health benefits concerning the immune system, hypertension, atherosclerosis, arthritis, and menopause-related dysfunctions, and might reduce the risk of cardiovascular problems, osteoporosis, or senile muscle weakness. - based on nutrigenomic and epigenomic principles, nutritional advice can benefit the relationship between genes and the nutritional habit-related consequences. Authors conclude that the use of each person’s genetic profile for the prescription of nutraceuticals is a major goal to be striven for in order to improve their effectiveness in the prevention and natural treatment of prevalent diseases.