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Potential effects of curcumin in the treatment of COVID-19 infection.

Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, HU3 2JZ, UK. Sabinsa Corporation, East Windsor, New Jersey, 08520, USA. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Clinical Biochemistry, Sultan Qaboos University Hospital, Muscat, Oman. Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Lodz, Poland. Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. Halal Research Center of IRI, FDA, Tehran, Iran. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Phytotherapy research : PTR. 2020;(11):2911-2920
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Abstract

Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. In this study, we review some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2.

Methodological quality

Publication Type : Review

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