Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome.

Luis Chiscano-Camón, Juan Carlos Ruiz-Rodriguez, Adolf Ruiz-Sanmartin, Oriol Roca, Ricard Ferrer

Journal: Critical care (London, England) 2020;24(1):522

PMID: 32847620

Free Full Text on BioMed Central View on PubMed

Plain Language Summary

Sepsis related acute respiratory disease (ARDS) is associated with Covid-19. ARDS patients can present with decreased levels of vitamin C and so by association Covid-19 patients may also have low vitamin C levels. In this cohort study, 18 Covid-19 ARDS patients of which all survived were assessed for vitamin C levels. 17 patients had undetectable levels of vitamin C and one had low levels. It was concluded that more than 90% of the patients in this study had undetectable levels of vitamin C, which may be due to several reasons, such as reduced absorption of vitamin C in the gut and decreased production. Clinicians could use this study to understand the importance of monitoring vitamin C levels in patients with Covid-19.

Abstract

Address: Intensive Care Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, Barcelona, 08035, Spain.; Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, Barcelona, 08035, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain.; Intensive Care Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, Barcelona, 08035, Spain. [email protected].; Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, Barcelona, 08035, Spain. [email protected].; Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain. [email protected].; Ciber Enfermedades Respiratorias (Ciberes), Instituto de Salud Carlos III, Madrid, Spain.

DOI: 10.1186/s13054-020-03249-y

Patient Centred Factor

Triggers: Covid-19

Clinical Imbalances

Immune and inflammation

Laboratory Testing

Blood

Nutrition Evidence Keywords

COVID-19 Vitamin C Immunity ARDS Vitamin C deficiency Acute respiratory disease

Bioactive Substances

Vitamin C

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/vitaminc.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-438

MeSH Terms: Aged, Ascorbic Acid, COVID-19, Coronavirus Infections, Female, Humans, Intensive Care Units, Male, Middle Aged, Pandemics, Pneumonia, Viral, Respiratory Distress Syndrome