Rheumatology Service, Hospital del Mar, Passeig Marítim, Barcelona 08003 , Spain. IMIM (Hospital del Mar Medical Research Institute), PRBB, Barcelona 08003, Spain. Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d’Investigacions Mèdiques, PRBB, Barcelona 08003, Spain. Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, Barcelona 08003, Spain. CAP Vila Olímpica, Parc Sanitari Pere Virgili, Barcelona 08005, Spain. Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III (ISCIII), Madrid 28029, Spain. Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, Barcelona 08003, Spain.