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Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development.

Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy; UOSVD Anesthesia and Intensive Care, Fondazione Toscana G. Monasterio, Pisa, Italy. Electronic address: v.lionetti@santannapisa.it. Regenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy. Department of NEUROFARBA, Center of Molecular Medicine, University of Firenze, 50139 Firenze, Italy. Department of Bioscience, Biotechnology and Biopharmaceuticals, University of Bari, Bari, Italy. Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy. Department of Advanced Biomedical Sciences, Federico II University, Italy. Institute of Cardiology, University of Pisa, Pisa, Italy; Center for Cardiovascular Biology and Atherosclerosis Research, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA. Unit of Cardiovascular Science, Campus Bio-Medico University, Rome, Italy. Department of Medicine and Surgery, University of Parma, Parma, Italy. Department of Biology and Biotechnology, Laboratory of General Physiology, University of Pavia, Pavia, Italy. Electronic address: francesco.moccia@unipv.it. Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy. Clinical and Biological Sciences Department, University of Turin, Orbassano, Turin, Italy. Department of Health Sciences, University of Florence, Florence, Italy. Department of Health Science, University of Magna Graecia, Catanzaro, Italy. Department of Medicine and Surgery, Hematology and Bone Marrow Transplantation, University Hospital of Parma, Via Gramsci 14, 43126 Parma, Italy. Laboratory of Cellular and Molecular Cardiovascular Patho-Physiology, Department of Biology, E. and E.S., University of Calabria, Arcavacata di Rende, CS, Italy. Department of Health Science, University of Milano, Milan, Italy. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. Interdepartmental Center of Clinical and Translational Research, Federico II University, Naples, Italy.

Pharmacological research. 2021;:105581
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Abstract

In-depth characterization of heart-brain communication in critically ill patients with severe acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-19) pandemic era during intensive care unit (ICU) stay and after ICU or hospital discharge. Emerging research has provided new insights into pathogenic role of the deregulation of the heart-brain axis (HBA), a bidirectional flow of information, in leading to severe multiorgan disease syndrome (MODS) in patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Noteworthy, HBA dysfunction may worsen the outcome of the COVID-19 patients. In this review, we discuss the critical role HBA plays in both promoting and limiting MODS in COVID-19. We also highlight the role of HBA as new target for novel therapeutic strategies in COVID-19 in order to open new translational frontiers of care. This is a translational perspective from the Italian Society of Cardiovascular Researches.

Methodological quality

Publication Type : Review

Metadata

MeSH terms : Heart