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"Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis".

Clinical Epidemiology Unit, All India Institute of Medical Sciences, New Delhi, India. Electronic address: rawat.dimple96@gmail.com. Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: roy.avishek1992@gmail.com. Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: souvikmaitra@live.com. Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India. Electronic address: drshankarvivek@gmail.com. Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: k.punit@yahoo.com. Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: dalimkumar.ab8@gmail.com.

Diabetes & metabolic syndrome. 2021;(4):102189
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Abstract

BACKGROUND Vitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2. METHODS Meta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done. RESULTS Total 5 studies (3 RCTs and 2 Quasi-experimental) including n = 467 patients were included. Vitamin D didn't reduce mortality (RR 0.55, 95%CI 0.22 to 1.39, p = 0.21), ICU admission rates (RR 0.20, 95% CI 0.01-4.26, p = 0.3) and need for invasive ventilation (RR 0.24, 95% CI 0.01-7.89, p = 0.42). CONCLUSION No significant difference with vitamin-D supplementation on major health related outcomes in COVID-19. Well-designed RCTs are required addressing this topic.

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Publication Type : Meta-Analysis

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