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The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

Usher Institute, University of Edinburgh, Edinburgh, UK.The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.Usher Institute, University of Edinburgh, Edinburgh, UK.Asthma UK and British Lung Foundation, London, UK.National Heart & Lung Institute, Imperial College London, London, UK.Asthma UK and British Lung Foundation, London, UK.The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.UCL Respiratory, University College London, London, UK.School of Medicine, University of Dundee, Dundee, UK.Barts Health NHS Trust and Queen Mary University of London, London, UK.The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.Usher Institute, University of Edinburgh, Edinburgh, UK.Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, N Ireland, UK.Usher Institute, University of Edinburgh, Edinburgh, UK.Usher Institute, University of Edinburgh, Edinburgh, UK.Population Health Science Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle, UK. Electronic address: anthony.de-soyza@newcastle.ac.uk.

The Lancet. Respiratory medicine. 2021;(12):1467-1478
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Abstract

Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.

Methodological quality

Publication Type : Review

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MeSH terms : COVID-19