The effects of phosphocreatine disodium salts plus blueberry extract supplementation on muscular strength, power, and endurance.

John Paul V Anders, Tyler J Neltner, Robert W Smith, Joshua L Keller, Terry J Housh, F Joseph Daugherty, Michael S Tempesta, Alekha K Dash, Daniel J Munt, Richard J Schmidt, Glen O Johnson

Journal: Journal of the International Society of Sports Nutrition 2021;18(1):60

PMID: 34503541

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Plain Language Summary

The effects of polyphenols and phosphocreatine supplementation on exercise performance, muscular strength, power, and endurance are largely unknown. This randomised, double-blinded, placebo-controlled, parallel-design trial aimed to differentiate the effects of a blend of 5 grams of phosphocreatine disodium salts plus 200 mg blueberry extract (PCDSB), 3 grams of Creatinine monohydrate (CM), and placebo on measures of muscular strength, power, and endurance. PCDSB contained 60 grams of phenols and 2.5 grams of pure creatine, and CM contained 2.4 grams of pure creatin. During this trial, thirty-three men took random supplements for 28 days and kept up their regular exercise regimen. In both PCDSB and CM, Peak torque (PT) and Average power (AP) increased after 28 days of supplementation with no effect on fatigue-induced PT% and AP% or body mass. Additionally, a greater proportion of participants showed a meaningful increase in muscular strength to PCDSB than to CM. To evaluate the additive effects of ingredients in the PCDSB supplement, longer-term studies are needed with larger supplementation doses. The study provides insight into the ergogenic effects of PCDSB and CM for healthcare practitioners.

Abstract

BACKGROUND

Numerous studies have demonstrated the efficacy of creatine supplementation for improvements in exercise performance. Few studies, however, have examined the effects of phosphocreatine supplementation on exercise performance. Furthermore, while polyphenols have antioxidant and anti-inflammatory properties, little is known regarding the influence of polyphenol supplementation on muscular strength, power, and endurance. Thus, the purpose of the present study was to compare the effects of 28 days of supplementation with phosphocreatine disodium salts plus blueberry extract (PCDSB), creatine monohydrate (CM), and placebo on measures of muscular strength, power, and endurance.

METHODS

Thirty-three men were randomly assigned to consume either PCDSB, CM, or placebo for 28 days. Peak torque (PT), average power (AP), and percent decline for peak torque (PT%) and average power (AP%) were assessed from a fatigue test consisting of 50 maximal, unilateral, isokinetic leg extensions at 180°·s before and after the 28 days of supplementation. Individual responses were assessed to examine the proportion of subjects that exceeded a minimal important difference (MID).

RESULTS

The results demonstrated significant (p < 0.05) improvements in PT for the PCDSB and CM groups from pre- (99.90 ± 22.47 N·m and 99.95 ± 22.50 N·m, respectively) to post-supplementation (119.22 ± 29.87 N·m and 111.97 ± 24.50 N·m, respectively), but no significant (p = 0.112) change for the placebo group. The PCDSB and CM groups also exhibited significant improvements in AP from pre- (140.18 ± 32.08 W and 143.42 ± 33.84 W, respectively) to post-supplementation (170.12 ± 42.68 W and 159.78 ± 31.20 W, respectively), but no significant (p = 0.279) change for the placebo group. A significantly (p < 0.05) greater proportion of subjects in the PCDSB group exceeded the MID for PT compared to the placebo group, but there were no significant (p > 0.05) differences in the proportion of subjects exceeding the MID between the CM and placebo groups or between the CM and PCDSB groups.

CONCLUSIONS

These findings indicated that for the group mean responses, 28 days of supplementation with both PCDSB and CM resulted in increases in PT and AP. The PCDSB, however, may have an advantage over CM when compared to the placebo group for the proportion of individuals that respond favorably to supplementation with meaningful increases in muscular strength.

Address: Department of Nutrition and Human Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68510, USA. [email protected].; Department of Nutrition and Human Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68510, USA.; Department of Health, Kinesiology and Sport, University of South Alabama, Mobile, AL, 36688, USA.; Phenolics LLC, Omaha, NE, 68144, USA.; Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Omaha, NE, 68178, USA.

DOI: 10.1186/s12970-021-00456-y

Patient Centred Factor

Mediators: phosphocreatine disodium salts plus blueberry extract and creatine monohydrate

Clinical Imbalances

Gastro-intestinal Structural Integrity and Musculoskeletal

Modifiable Lifestyle Factors

Diet Exercise and movement

Jadad Score

Allocation Concealment

Yes

Nutrition Evidence Keywords

Antioxidant Oxidative stress Anthocyanins Exercise performance Polyphenol Phosphocreatine disodium salts Blueberry extract Vaccinium angustifolium berries Anti-inflammatory properties Proanthocyanins Creatine monohydrate Peak torque (PT) Average power (AP) Muscular strength, power, and endurance

Bioactive Substances

Polyphenols and creatinine Blueberry extract

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MeSH Terms: Blueberry Plants, Creatine, Dietary Supplements, Double-Blind Method, Humans, Male, Muscle Strength, Muscle, Skeletal, Phosphocreatine, Physical Endurance, Plant Extracts, Torque, Young Adult