Effect of an exercise bout before the booster dose of an inactivated SARS-CoV-2 vaccine on immunogenicity in immunocompromised patients.

Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Food Research Center, University of São Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Endocrinology, Metabolism, and Diabetes and Anschutz Health and Wellness Center, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Pediatric Rheumatology Unit, Faculdade de Medicina, Instituto da Criança e do Adolescente, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.Applied Physiology & Nutrition Research Group, Division of Rheumatology, Faculdade de Medicina FMUSP, School of Physical Education and Sport, Universidade de Sao Paulo, Sao Paulo, Brazil.Division of Rheumatology, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.

Journal of applied physiology (Bethesda, Md. : 1985). 2022;(3):682-688
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Abstract

This randomized controlled study aimed to investigate whether a single bout of exercise before the homologous booster dose of a SARS-CoV-2 inactivated vaccine could enhance immunogenicity in patients with spondyloarthritis. We selected 60 consecutive patients with spondyloarthritis (SpA). Patients assigned to the intervention group performed an exercise bout comprising three exercises. Then, they remained at rest for 1 h before vaccination. The control group remained at rest before vaccination. Immunogenicity was assessed before (Pre) and 1 mo after (Post) the booster using seropositivity rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), frequency of neutralizing antibodies (NAb) positivity, and NAb activity. At Pre, 16 patients from the exercise group and 16 patients from the control group exhibited seropositivity for IgG (59% vs. 57.1%), and 1 mo after the booster dose, seropositivity occurred in 96% versus 100% of the cases. Only 10 patients from the exercise group and 12 patients from the control group showed positive NAb serology at Pre (37% vs. 42.8%). One month following the booster, NAb positivity was 96% versus 93%. GMT was comparable between groups at Pre. At Post, GMT increased similarly in both groups. Likewise, NAb activity was similar between groups at Pre and increased similarly in both of them as a result of the booster (47.5% vs. 39.9%). In conclusion, a single bout of exercise did not enhance immunogenicity to a homologous booster dose of an inactivated SARS-CoV-2 vaccine among patients with spondyloarthritis.NEW & NOTEWORTHY We tested the role of exercise as an adjuvant to a booster of a COVID-19 vaccine. Immunocompromised patients were immunized after an acute bout of exercise or not. Patients exhibited an excellent immunogenicity in response to the booster dose. Exercise did not add to the vaccine effects on IgG or neutralizing antibodies.

Methodological quality

Publication Type : Randomized Controlled Trial

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