Department of Medicine, Faculty of Medicine, Imperial College London, London SW7 2AD, UK.Department of Medicine, Faculty of Medicine, Imperial College London, London SW7 2AD, UK.King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.