The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial.

A Conforti, G G Iorio, R Di Girolamo, M Y Rovetto, S Picarelli, F Cariati, R Gentile, A D'Amato, O Gliozheni, B Fioretti, C Alviggi

Journal: Journal of ovarian research 2024;17(1):81

PMID: 38622741

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Plain Language Summary

Resveratrol is a natural polyphenol found in plants and red wine, known for its health benefits. It has anti-inflammatory and anti-tumor effects and supports cellular mitochondrial function. This study aimed to evaluate the effect of resveratrol-based supplementation on ovarian responsiveness in advanced reproductive age women with normal ovarian reserve markers as candidates to vitro fertilisation (IVF). This study was a randomised, single-blind, controlled, single-centre, experimental study which enrolled infertile women attending in IVF. Participants were randomly assigned to one of the two groups (1:1). Results showed that resveratrol pretreatment for three months before IVF did not significantly improve pregnancy rates but increased ovarian response to fertility treatments. Women who took resveratrol had higher FORT and FOI [ovarian sensitivity indicators] levels, and a slight, though not significant, increase in OSI [ovarian sensitivity indicator] compared to the control group. Authors concluded that pre-treatment with resveratrol may decrease the risk of unexpected hyporesponse to OS in advanced reproductive aged women.

Abstract

BACKGROUND

Resveratrol is a natural polyphenolic compound present in plants and red wine with many potential health benefits. This compound has various anti-inflammatory and anti-tumor properties and can improve cellular mitochondrial activity. This trial was designed to evaluate the effect on the outcome of IVF of Resveratrol supplementation in women > 35 years with good ovarian reserve (AMH > 1.2 ng/ml). Women were randomized to receive or placebo or Resveratrol (150 mg per day) for three months preceding the ovarian stimulation (OS). All patients were stimulated with a starting dose of recombinant FSH ranging between 150 and 300 IU according to age and ovarian reserve. GnRH antagonist flexible protocol was adopted for pituitary suppression. Triggering was performed with urinary hCG (10.000 IU).

RESULTS

The study was conducted between January 2019 and December 2022 with aa total of 37 cases and 33 controls were recruited. No statistically significant differences in the number of oocytes retrieved, biochemical pregnancy, clinical pregnancy and live birth rates were observed between women treated with resveratrol and control group. A statistically significant increase in the follicle output rate (FORT) and follicle-to oocyte index (FOI) was observed in women treated with resveratrol-based nutraceutical (0.92 versus 0.77 [p = 0.02], and 0.77 versus 0.64 [p = 0.006], respectively).

CONCLUSIONS

Preliminary results from this study indicate that pre-treatment with resveratrol may improve ovarian sensitivity to exogenous FSH, which in turn may decrease the risk of hypo-response to OS in advanced reproductive age women.

Address: Department of Neuroscience, Reproductive Science and Odontostomatology, School of Medicine, University of Naples "Federico II, Naples, Italy, Via Sergio Pansini, 5, 80131.; Department of Neuroscience, Reproductive Science and Odontostomatology, School of Medicine, University of Naples "Federico II, Naples, Italy, Via Sergio Pansini, 5, 80131. [email protected].; Department of Public Health. School of Medicine, University of Naples "Federico II, Naples, Italy.; Department of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy.; Department of Interdisciplinary Medicine, University of Bari, 1St Unit of Obstetrics and Gynecology, Bari, Italy.; Head of Department of Obstetrics and Gynecology, University Hospital for Obstetrics & Gynecology, University of Medicine of Tirana, KocoGliozheni", Tirana, Albania.

DOI: 10.1186/s13048-024-01391-7

Patient Centred Factor

Triggers: Resveratrol supplementation

Clinical Imbalances

Hormonal Immune and inflammation

Laboratory Testing

Blood

Modifiable Lifestyle Factors

Diet

Jadad Score

Allocation Concealment

Yes

Nutrition Evidence Keywords

Fertility Resveratrol Mitochondria IVF

Bioactive Substances

Resveratrol Gonadotropin

Link outs

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MeSH Terms: Pregnancy, Female, Humans, Resveratrol, Pregnancy Rate, Gonadotropin-Releasing Hormone, Fertilization in Vitro, Pregnancy Outcome, Ovulation Induction, Follicle Stimulating Hormone