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ADHD and Nutrition - NED Infobite
Infobite 41_September 2023. Summaries of key research on ADHD and aspects of nutrition
2024
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition that affects about 5-7% of children, which can persist into adulthood. This NED Infobite looks at gut health, Vitamin D and different aspects of dietary intake in relation with ADHD. BANT's scientific NED InfoBites are designed to provide key elements of the latest research using plain language. They provide quick overviews on particular health issues and nutrition topics for a speedy introduction to the science. Visually attractive and easily shareable with clients and social media followers.
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The NED Journal - Male Health, ADHD and Neurodiversity, Stress and Adrenals
Issue 2_December 2023 Peer-reviewed expert reviews and clinical insights from the Nutrition Evidence Editorial Board and Expert Review Panel
2024
Abstract
In this 2nd edition of the NED Journal, you can read some of the latest expert insights on male health, ADHD and neurodiversity, and stress and adrenals. This NED Journal transforms the science to enable individualised science-based clinical decision making, with 14 peer-reviewed expert reviews. The NED Journal supports BANT members and other integrative and personalised medicine practitioners with their evidence-based practice.
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The NED Journal - Healthy Ageing and Longevity
Issue 4_August 2024. Peer-reviewed expert reviews and clinical insights from the Nutrition Evidence Editorial Board and Expert Review Panel
2024
Abstract
In this 4th edition of the NED Journal, you can read some of the latest expert insights on different aspects of health and ageing. It includes 15 expertly reviewed scientific articles on osteoporosis, longevity and Blue Zones, and the ageing brain. The NED Journal transforms the science to enable individualised science-based clinical decision making and supports BANT members and other integrative and personalised medicine practitioners with their evidence-based practice.
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Effects of a Yoga Program Combined with a Mediterranean Diet on Nutritional Status and Functional Capacity in Community-Dwelling Older Adults: A Randomized Controlled Clinical Trial.
Carcelén-Fraile, MDC, Martín-Baute, MR, Ledesma-Cerrato, MI, Castellote-Caballero, Y, González-Martín, AM, Hita-Contreras, F, Cano-Sánchez, J, Aibar-Almazán, A
Nutrients. 2024;16(11)
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The ageing process involves a series of changes in various areas, including body composition which tends to change in older adults, with an increase in body fat and a decrease in muscle mass. Therefore, it is necessary to implement a series of strategies that contribute to maintaining and/or improving the changes that ageing brings with it. This study aimed to assess the effects and scope of a combined therapy of yoga along with the Mediterranean diet on the nutritional status and functional capacity of non-institutionalised older adults. This study was a 12-week randomised controlled trial. Participants (n=118) were randomly assigned to the experimental group (EG) and the control group (CG). Results showed that: - nutritional status significantly improved in the experimental group. - experimental group showed greater balance, gait, and flexibility compared to the control group. - grip strength and lower body strength also improved in the experimental group. Authors concluded that their findings may support the need for public policies that promote physical exercise programs and healthy diets aimed at older adults, as part of disease prevention and health promotion strategies.
Abstract
(1) Background: With the aging population, effective interventions are needed to enhance the health of older adults. This study investigated the combined effects of yoga and the Mediterranean diet on various health outcomes in community-dwelling older adults; (2) Methods: The study employed a randomized controlled trial design with a total of 116 older adults randomized to an experimental group (n = 57) that underwent a combined yoga and Mediterranean diet program and a control group (n = 59) that did not receive any intervention. Nutritional status was assessed using the Mini Nutritional Assessment, flexibility with the Back Scratch Test and the Chair Sit-and-Reach Test, balance, gait, and fall risk with the Tinetti Scale, and muscle strength with a dynamometer and the 30 s Chair Stand Test; (3) Results: Regarding nutritional status, there were significant differences between the experimental group and the control group (Cohen's d = 0.02). The participants in the experimental group showed greater balance (11.12 ± 3.01 vs. 10.03 ± 2.35, Cohen's d = 0.41 and gait (7.63 ± 1.96 vs. 6.69 ± 2.50, Cohen's d = 0.44) with respect to the control group. In terms of flexibility, the experimental group showed statistically significant improvements in the right arm (Cohen's d = 0.43), left arm (Cohen's d = 0.64), right perineum (Cohen's d = 0.42), and left leg (Cohen's d = 0.37) Finally, in terms of strength, participants in the experimental group experienced statistically significant improvements in grip strength and lower body strength (Cohen's d = 0.39 and 0.81, respectively); (4) Conclusions: The study highlights the potential benefits of a 12-week intervention combining yoga with a Mediterranean diet to improve the health and functional capacities of community-dwelling older adults.
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Exercise and Nutrition in the Mental Health of the Older Adult Population: A Randomized Controlled Clinical Trial.
Carcelén-Fraile, MDC, Déniz-Ramírez, NDP, Sabina-Campos, J, Aibar-Almazán, A, Rivas-Campo, Y, González-Martín, AM, Castellote-Caballero, Y
Nutrients. 2024;16(11)
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During the aging process, the body experiences a series of changes, such as decreased muscle mass, decreased bone density, and reduced immune system function. These changes can increase susceptibility to various diseases and health conditions, making a proper diet even more crucial. This research aims to examine the effectiveness of resistance programmes and the Mediterranean diet in managing anxiety, depression, sleep, and stress in older adult populations. This study was a randomised, controlled study with two arms: intervention vs control group (1:1). Results showed significant improvements in levels of anxiety, depression, and perceived stress, as well as in several aspects of sleep quality in the group that participated in the resistance training and diet programme compared to the control group. Authors concluded that a 12-week resistance programme is effective in improving various psychological and health parameters in older adults aged 65 or older.
Abstract
(1) Background: Global population aging is changing demographic structures and presents significant challenges for health systems, which must adapt to an increasingly elderly population. (2) Methods: The study employed a randomized controlled trial design with a total of 116 older adults aged 65 or older, randomly assigned to an experimental group (n = 57) undergoing a combined resistance program and Mediterranean diet program and a control group (n = 59) who did not receive any intervention. Anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale (HADS), sleep quality through the Pittsburgh Sleep Quality Index (PSQI), and perceived stress using the Perceived Stress Scale (PSS). (3) Results: Statistically significant improvements (p < 0.05) were observed both within and between groups in anxiety (Cohen's d = 0.38 and 0.78, respectively), depression (Cohen's d = 0.56 and 0.18, respectively), perceived stress (Cohen's d = 0.15 and 0.39, respectively), and in the PSQI domains: subjective sleep quality (Cohen's d = 1.01 and 0.53, respectively), sleep duration (Cohen's d = 0.112 and 0.53, respectively), sleep disturbances (Cohen's d = 1.92 and 0.95, respectively), use of medications (Cohen's d = 0.34 and 0.40, respectively), and the PSQI total score (Cohen's d = 0.68 and 0.49, respectively). No significant differences were observed in sleep latency or daytime dysfunction. (4) Conclusions: The results of the present study suggest that resistance intervention may be an effective therapeutic option to improve mental health and sleep quality in older adults aged 65 or older, offering a non-pharmacological approach to improving overall well-being in this demographic.
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Diet Quality Scores, Obesity and Metabolic Syndrome in Children and Adolescents: A Systematic Review and Meta-Analysis.
Larruy-García, A, Mahmood, L, Miguel-Berges, ML, Masip, G, Seral-Cortés, M, De Miguel-Etayo, P, Moreno, LA
Current obesity reports. 2024;13(4):755-788
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Literature shows that obesity among children and adolescents tends to persist into later life, thus increasing the risk of obesity during adulthood. Obesity is considered as a risk factor in the development of Metabolic Syndrome (MetS). This study aimed to analyse various diet quality scores and their association with obesity and MetS in children and adolescents. This study was a systematic review and meta-analysis of seventy-three articles. The studies were evaluated as cross sectional (n= 53, 72%), cohort (n=15, 22%), and clinical trials (n=4, 6%). Results showed that: - high adherence to the Mediterranean diet (MD) was associated with low obesity measures but only in adolescents. - greater adherence to the MD may have a protective effect against cardiovascular disease and the development of obesity. Authors concluded that high adherence to diet quality scores has a positive effect on obesity measures and MetS in children and adolescents.
Abstract
PURPOSE OF REVIEW We aimed to examine the relationship between various diet quality scores and obesity and Metabolic Syndrome (MetS) in children and adolescents. RECENT FINDINGS Obesity and MetS, which increase the risk of type 2 diabetes and cardiovascular disease from childhood through adolescence, have been associated with adherence to various diet quality scores. A systematic search was performed in PubMed/Medline, Scopus, SciELO, Embase, and Cochrane, covering the period until March 2024. Two researchers evaluated 3,519 studies according to the inclusion criteria. Finally, 73 articles that analysed the relationship between diet quality scores and obesity and MetS were included, and 6 of them were included in a meta-analysis. Children younger than 12 years old showed statistically significant differences indicating a higher Mediterranean diet (MD) score adherence compared to those with a low score adherence for BMI (MD = 0.33 kg/m2, 95% CI: 0.01, 0.64) and WC values (MD = 1.21 cm, 95% CI: 0.50, 1.93). Additionally, in the meta-regression analysis, boys showed stronger associations for BMI, z-score BMI and WC (β = 19.82, 95% CI: 17.62, 22.03, β = 0.64, 95% CI: 0.33, 0.96 and β = 67.03, 95% CI: 57.29, 76.77, respectively). Studies in this review suggest an association between high adherence to different diet quality scores and low BMI. Meta-analysis assessing the association between adherence to the MD and BMI, and WC, showed a protective effect of the MD pattern against obesity outcomes. This systematic review and meta-analyses provided evidence on the effect of the diet quality on obesity and MetS in children and adolescents.
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Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial.
Erol Doğan, Ö, Karaca Çelik, KE, Baş, M, Alan, EH, Çağın, YF
Nutrients. 2024;16(10)
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The Mediterranean diet (MD) is characterised by a high intake of plant-based foods, such as cereals, vegetables, fruits, and olive oil, with limited consumption of dairy products, sweets, sugar, and meat. Known for its anti-inflammatory properties, the MD has shown benefits for patients with inflammatory bowel disease. Research indicates that greater adherence to the MD in individuals with ulcerative colitis (UC)—a chronic inflammatory condition affecting the colon and rectal mucosa—can improve quality of life and help modulate disease activity. This study aimed to investigate the effects of the MD, in combination with curcumin and resveratrol supplementation, on disease activity, serum inflammatory markers, and quality of life in patients with mild-to-moderate active UC. This research was a prospective multicentre three-arm randomised controlled study. Participants (n=46) were randomly separated into the MD, MD + curcumin, and MD + resveratrol groups. Results showed that the MD was effective in achieving disease remission, regulating inflammatory markers, and enhancing the quality of life of individuals with mild-to-moderate active UC. Furthermore, curcumin and resveratrol supplements do not produce a summation of effects when administered in addition to the dietary intervention. Authors concluded that the MD is an effective and safe intervention to be used in clinical practice in individuals with UC.
Abstract
This study aimed to investigate the effects of the Mediterranean diet (MD), combined with curcumin and resveratrol supplementation, on disease activity, serum inflammatory markers, and quality of life in patients with mild-to-moderate active ulcerative colitis (UC). This study was designed as a prospective multicenter three-arm randomized controlled trial. Participants were randomized to the MD, MD + curcumin, and MD + resveratrol groups. All participants were placed on the MD for 8 weeks. The MD + curcumin group also received 1600 mg/day of curcumin supplementation, whereas the MD + resveratrol group received 500 mg/day of resveratrol supplementation for 8 weeks. Anthropometric measurements, Truelove-Witts Index, Short Form-36, Inflammatory Bowel Disease Questionnaire, Mediterranean Diet Adherence Scale (MEDAS), and laboratory tests were performed at baseline and postintervention. Within-group comparisons showed that MD, MD + curcumin, and MD + resveratrol interventions were effective in reducing disease activity and inflammation and improving quality of life in individuals with UC (p < 0.05). Between-group comparisons revealed no significant difference in all parameters except for the pain subparameter of SF-36 and the MEDAS score (p < 0.05). The MD is an effective and safe intervention to be used in clinical practice in individuals with UC.
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Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome.
Rossello, X, Ramallal, R, Romaguera, D, Alonso-Gómez, ÁM, Alonso, A, Tojal-Sierra, L, Fernández-Palomeque, C, Martínez-González, MÁ, Garrido-Uriarte, M, López, L, et al
European journal of preventive cardiology. 2024;31(5):629-639
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Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and a risk factor for stroke, heart failure, dementia, and mortality. AF is a progressive disease, with many patients advancing over time from subclinical states (changes in the atrial substrate) to clinical forms of the arrhythmia. The aim of this study was to evaluate the effect of an intensive lifestyle intervention (ILI) based on an energy-reduced Mediterranean diet (MedDiet), increased physical activity, and cognitive-behavioural weight management on the underlying structural and functional cardiac substrate of AF in overweight or obese people with metabolic syndrome (Mets). This study was an ancillary study of the PREDIMED-Plus trial. The trial was a multi-centre, randomised trial for the primary prevention of cardiovascular disease in overweight/obese individuals with Met. Participants were randomised 1:1 to an ILI programme based on an energy-reduced MedDiet, increased physical activity, and cognitive behavioural weight management or to a control intervention of low-intensity dietary advice on the MedDiet for at least 6 years. Results showed that an ILI programme based on an energy-reduced MedDiet, increased physical activity, and cognitive behavioural weight management did not show a significant impact on the structural and functional cardiac substrate of AF compared to the control intervention of low-intensity dietary advice on the MedDiet. Authors concluded that an ILI had no impact on the underlying structural and functional cardiac substrate of AF in overweight or obese people with Mets.
Abstract
AIMS: To evaluate the effect of an intensive lifestyle intervention (ILI) on the structural and functional cardiac substrate of atrial fibrillation (AF) in overweight or obese people with metabolic syndrome (Mets). METHODS AND RESULTS Participants of the PREvención con DIeta MEDiterranea-Plus trial (n = 6874) were randomized 1:1 to an ILI programme based on an energy-reduced Mediterranean diet, increased physical activity, and cognitive-behavioural weight management or to a control intervention of low-intensity dietary advice. A core echocardiography lab evaluated left atrial (LA) strain, function, and volumes in 534 participants at baseline, 3-year, and 5-year follow-ups. Mixed models were used to evaluate the effect of the ILI on LA structure and function. In the subsample, the baseline mean age was 65 years [standard deviation (SD) 5 years], and 40% of the participants were women. The mean weight change after 5 years was -3.9 kg (SD 5.3 kg) in the ILI group and -0.3 kg (SD 5.1 kg) in the control group. Over the 5-year period, both groups experienced a worsening of LA structure and function, with increases in LA volumes and stiffness index and decreases in LA longitudinal strain, LA function index, and LA emptying fraction over time. Changes in the ILI and control groups were not significantly different for any of the primary outcomes {LA emptying fraction: -0.95% [95% confidence interval (CI) -0.93, -0.98] in the control group, -0.97% [95% CI -0.94, -1.00] in the ILI group, Pbetween groups = 0.80; LA longitudinal strain: 0.82% [95% CI 0.79, 0.85] in the control group, 0.85% [95% CI 0.82, 0.89] in the ILI group, Pbetween groups = 0.24} or any of the secondary outcomes. CONCLUSION In overweight or obese people with Mets, an ILI had no impact on the underlying structural and functional LA substrate measurements associated with AF risk. This study evaluated whether an intervention-modifying lifestyle had an effect on the parts of the heart involved in the development of atrial fibrillation (AF), a common problem of the heart rhythm. This intervention was implemented in people who had excessive body weight and the metabolic syndrome (Mets), which is a combination of several cardiovascular risk factors. The lifestyle intervention included promoting a Mediterranean diet low in calories and increasing exercise to facilitate weight loss, and this intervention was compared with a control intervention to follow a healthy diet. We performed repeated studies of the heart structure and function with imaging over a period of 5 years. During the 5 years of the study, both study groups (intervention and control) showed changes in their heart consistent with ageing. However, these changes were not different in those who were receiving the lifestyle intervention. Also, participants who lost more weight, adhered better to the study diet, or did more physical activity, overall did not show any differences in their heart compared with those who did not achieve their lifestyle goals.In conclusion, a lifestyle intervention focusing on weight loss, better diet, and more exercise was not effective in improving parts of the heart potentially involved with the risk of AF.In people with metabolic syndrome, a weight control lifestyle intervention, based on an energy-reduced Mediterranean diet and physical activity, had no effect on the structural and functional cardiac substrate of atrial fibrillation.
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The Effect of a Ketogenic Diet versus Mediterranean Diet on Clinical and Biochemical Markers of Inflammation in Patients with Obesity and Psoriatic Arthritis: A Randomized Crossover Trial.
Lambadiari, V, Katsimbri, P, Kountouri, A, Korakas, E, Papathanasi, A, Maratou, E, Pavlidis, G, Pliouta, L, Ikonomidis, I, Malisova, S, et al
International journal of molecular sciences. 2024;25(5)
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Psoriatic arthritis is an autoimmune disorder marked by persistent inflammation. Recent studies suggest a connection between obesity and psoriasis, as visceral fat contributes to systemic inflammation through the release of inflammatory cytokines and adipocytokines. Dietary approaches like the Mediterranean diet (MD) and Ketogenic diet (KD) can potentially aid in weight loss and inflammation reduction. This randomised crossover study examined the effectiveness of a classic Mediterranean diet and an isocaloric Ketogenic diet over twenty-two weeks in patients with psoriatic arthritis, obesity, and pre-existing psoriasis. The findings demonstrated significant improvements in weight, body mass index, waist circumference, total fat mass, and visceral fat with both the Mediterranean and Ketogenic diets. However, the Ketogenic diet showed a statistically significant improvement in psoriasis and psoriatic arthritis, as well as in the levels of inflammatory biomarkers, compared to the Mediterranean diet. Healthcare professionals can leverage the findings of this study to understand the beneficial effects of the Mediterranean and Ketogenic diets on metabolic markers, inflammatory markers, and psoriasis. However, additional robust studies are needed to confirm these results, as the existing research on this topic is limited.
Abstract
The effect of different diet patterns on psoriasis (PSO) and psoriatic arthritis (PSA) is unknown. Τhe aim of our study was to evaluate the effectiveness of a Mediterranean diet (MD) and Ketogenic diet (KD), in patients with PSO and PSA. Twenty-six patients were randomly assigned to start either with MD or KD for a period of 8 weeks. After a 6-week washout interval, the two groups were crossed over to the other type of diet for 8 weeks. At the end of this study, MD and KD resulted in significant reduction in weight (p = 0.002, p < 0.001, respectively), in BMI (p = 0.006, p < 0.001, respectively), in waist circumference (WC) (p = 0.001, p < 0.001, respectively), in total fat mass (p = 0.007, p < 0.001, respectively), and in visceral fat (p = 0.01, p < 0.001, respectively), in comparison with baseline. After KD, patients displayed a significant reduction in the Psoriasis Area and Severity Index (PASI) (p = 0.04), Disease Activity Index of Psoriatic Arthritis (DAPSA) (p = 0.004), interleukin (IL)-6 (p = 0.047), IL-17 (p = 0.042), and IL-23 (p = 0.037), whereas no significant differences were observed in these markers after MD (p > 0.05), compared to baseline. The 22-week MD-KD diet program in patients with PSO and PSA led to beneficial results in markers of inflammation and disease activity, which were mainly attributed to KD.
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How to reduce brain inflammation: 4 actions you can take today
Dr Ruscio is a Doctor of Natural Medicine, Doctor of Chiropractic, clinical researcher and author. His podcast, Dr Ruscio Radio presents cutting edge information in health, nutrition and functional medicine distilled into practical advice that can be used to improve our health.
2023
Abstract
Dr Ruscio focuses on the link between brain inflammation and neurodegenerative diseases such as Alzheimer’s and Parkinson’s but also brain fog and mood. He summarises how it might be possible to reduce neuroinflammation through diet, looking at the links with dysbiosis and leaky gut but also exercise, sleep hygiene, and stress management. A concise overview of the evidence for diets such as Paleo, Low FODMAP, Ketogenic and Low Carb, as well as the Mediterranean diet for reducing inflammation and supporting brain health is provided. The potential for lab testing via anti and pro-inflammatory markers is also reviewed.