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IgG Antibodies & IBD/IBS - NED Infobite
BANT's scientific NED InfoBites are designed to provide key elements of the latest research using plain language. They provide quick overviews on particular health issues and nutrition topics for a speedy introduction to the science. Visually attractive and easily shareable with clients and social media followers.
2024
Abstract
Elimination diets based on IgG-dependent food sensitivity are showing promise for conditions such as IBS, Crohn's disease and migraines. This NED Infobite highlights a number of clinical trials where IgG food sensitivity testing is put to the test.
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Lifestyle and Migraine - NED Infobite
BANT's scientific NED InfoBites are designed to provide key elements of the latest research using plain language. They provide quick overviews on particular health issues and nutrition topics for a speedy introduction to the science. Visually attractive and easily shareable with clients and social media followers.
2024
Abstract
The exact causes of migraine headaches are still unknown. It seems likely that the aetiology is multi-factorial. This NED Infobite includes studies looking at anti-inflammatory agents such as curcumin and omega-3's, the impacts of optimising Vitamin D and partaking exercise and how targeting overweight and obesity may also reduce the frequency and duration of migraines.
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The menstrual cycle: A seasonal guide
The Institute for Optimum Nutrition (ION) was founded in by 1984 by Patrick Holford with the support of twice Nobel Prize winner Professor Linus Pauling, ION has been successfully training nutritional therapists for more than 30 years and is recognised as one of the most respected training bodies of its kind in Europe. Their mission is to ‘educate and enthuse, instilling optimum nutrition as the foundation of health for all’.
2023
Abstract
This blog post summarises the hormonal changes that occur at each stage of the menstrual cycle and potential symptoms that may be experienced, aligning each stage with one of the four ‘seasons’. There is a focus on menstrual migraines and inflammation, which waxes and wanes throughout the cycle in accordance with fluctuating hormone levels. It is suggested that nutrition and lifestyle can be tailored to each ‘season’ to help optimise the cycle.
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The Functional Medicine Approach to Ending Migraine
Dr. Mark Hyman is a practicing family physician and an internationally recognised leader, speaker, educator, and advocate in the field of Functional Medicine. He is the founder and director of The UltraWellness Centre, the Head of Strategy and Innovation of the Cleveland Clinic Centre for Functional Medicine, a thirteen-time New York Times bestselling author, and Board President for Clinical Affairs for The Institute for Functional Medicine.
2022
Abstract
The causes of migraine appear to be multifactorial and can manifest in many different ways, so the importance of evaluating migraines from a Functional Medicine (FM) perspective to identify potential imbalances in the body is pivotal. Dr Mark Hyman speaks to Dr Todd LePine, an Institute for Functional Medicine Certificated Practitioner to discuss how to identify and eliminate migraines and the differences between the conventional and FM approach. They review the connection between migraines and gut health, nutrient deficiencies such as magnesium, histamine sensitivity, genetics, the role of mitochondria and also lifestyle factors such as sleep and stress which can exacerbate symptoms. Exploring dietary and sleeping patterns and stress exposure/management appears to be key for first line migraine prevention. However they also review functional testing that may be helpful to identify the root cause, and supplementing with Magnesium, CoQ10, and Vitamin B2.
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Eating for Migraines with Dr Jessica Briscoe and Dr Katy Munro
Dr Rupy Aujla is an NHS medical doctor who reversed his heart condition using a food and lifestyle approach after diving deep into the literature and learning more about nutritional medicine. He started the Doctor’s Kitchen in 2015, as a way to teach others how they can cook their way to health and showcase that food is medicine.
2022
Abstract
Rupy chats with Dr Jessica Briscoe and Dr Katy Munro from The National Migraine Centre, a national charity with a clinic providing evidence based support for migraine sufferers. A diverse conversation covering migraine diet myths, as well as diet and lifestyle factors that can both trigger and prevent migraines. From a dietary perspective, eating regularly and stabilising glucose levels appears to be a primary factor in preventing migraines, but the potential use of ketogenic diets for pain and migraine management is also explored. The evidence around caffeine, exercise, pre and probiotics, sleep, stress management and supplements like Magnesium, CoQ10, and Vitamin B2 are reviewed.
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Treating the Underlying Causes of Chronic Migraine
As the pioneer and global leader of Functional Medicine, the Institute of Functional Medicine (IFM) leads and catalyses the efforts of a large and expanding Functional Medicine ecosystem, including providers, educators, payers, industry leaders, regulators, and influencers.
2022
Abstract
Pinpointing the exact pathophysiology of migraines is challenging. This insight from the IFM looks at mitochondrial dysfunction, oxidative stress and gastrointestinal disorders as key players in the role of migraine development and progression. Research suggests that the prevalence of migraines can be increased with a number of gastrointestinal conditions such as helicobacter pylori infection, irritable bowel syndrome and coeliac disease. Nutrition interventions that have been shown to improve quality of life in chronic migraine sufferers includes the ketogenic diet and nutrient supplementation with riboflavin, CoQ10 and magnesium.
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Decreasing Migraine Frequency with Nutrition
As the pioneer and global leader of Functional Medicine, the Institute of Functional Medicine (IFM) leads and catalyses the efforts of a large and expanding Functional Medicine ecosystem, including providers, educators, payers, industry leaders, regulators, and influencers.
2022
Abstract
It is proposed that nutritional interventions for migraines might reduce migraine occurrence and increase the quality of life for migraine sufferers. Immune mediated food sensitivities have been implicated as an underlying factor and evidence suggests that IgG based elimination diets may reduce the quantity of migraines. Supplements such as CoQ10, magnesium citrate, riboflavin, cinnamon, and vitamin D (if deficient) may also reduce the frequency of migraine attacks. Given that cardiovascular and neurological comorbidities have been closely associated with migraines it is interesting that dietary approaches such as the DASH (Dietary Approaches to Stop Hypertension) and MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diets have been shown to reduce headache severity. The role of fatty acids is also highlighted as studies have linked omega-3 fatty acid intake with migraine prophylaxis, providing another avenue for migraine support.
Sponsored Journal Article
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IgG-Based Elimination Diet in Migraine Plus Irritable Bowel Syndrome
Headache publishes original articles on all aspects of head and face pain including communications on clinical and basic research, diagnosis and management, epidemiology, genetics, and pathophysiology of primary and secondary headaches, cranial neuralgias, and pains referred to the head and face. Monthly issues feature case reports, short communications, review articles, letters to the editor, and news items regarding AHS plus medicolegal and socioeconomic aspects of head pain. This is the official journal of the American Headache Society.
2022
Abstract
OBJECTIVES To evaluate therapeutic potential of the immunoglobulin G (IgG)-based elimination diet among migraine patients with irritable bowel syndrome (IBS). BACKGROUND Food elimination has been suggested as an effective and inexpensive therapeutic strategy in patients with migraine and concomitant IBS in the past studies. METHODS A total of 21 patients (mean [standard deviation] age: 38.0 [11.2] years; 85.7% females) diagnosed with migraine and IBS were included in this double-blind, randomized, controlled, cross-over clinical trial composed of baseline (usual diet), first diet (elimination or provocation diets), and second diet (interchange of elimination or provocations diets) phases and 4 visits. RESULTS IgG antibody tests against 270 food antigens revealed mean (standard deviation) reaction count to be 23.1 (14.1). Compared with baseline levels, elimination diet per se was associated with significant reductions in attack count (4.8 [2.1] vs 2.7 [2.0]; P < .001), maximum attack duration (2.6 [0.6] vs. 1.4 [1.1] days; P < .001), mean attack duration (1.8 [0.5] vs. 1.1 [0.8] days; P < .01), maximum attack severity (visual analog scale 8.5 [1.4] vs. visual analog scale 6.6 [3.3]; P < .001), and number of attacks with acute medication (4.0 [1.5] vs. 1.9 [1.8]; P < .001). There was a significant reduction in pain-bloating severity (1.8 [1.3] vs. 3.2 [0.8]; P < .05), pain-bloating within the last 10 days (3.2 [2.8] vs. 5.5 [3.1]; P < .05), and improvement obtained in quality of life (3.6 [1.4] vs. 2.9 [1.0]; P < .05) by the elimination diet as compared with provocation diet. CONCLUSION Our findings indicate that food elimination based on IgG antibodies in migraine patients who suffer from concomitant IBS may effectively reduce symptoms from both disorders with possible positive impact on the quality of life of the patients as well as potential savings to the health-care system.
Sponsored Journal Article
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The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature Review
Current Pain and Headache Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of pain and headache.
2022
Abstract
Purpose of Review: This literature review describes the relationship between IgG food sensitivities and their relation to migraine headaches. Recent Findings: IgG food sensitivities have been linked to various symptoms and disorders. While food sensitivities and intolerances are recognized within the clinical medicine community, diagnosing these sensitivities and intolerances can be challenging because symptoms are usually delayed hours to days and may not occur after every exposure to the allergen. Some reports indicate that foods such as chocolate, cheese, cow’s milk, eggs, and red wine may be triggers for migraine headaches. Summary: The pathophysiology of migraine headaches is not well understood. Some evidence supports the use of IgG food sensitivity testing to determine food sensitivities and intolerances. IgG food sensitivity testing may prove to be a beneficial tool for healthcare practitioners, especially for patients experiencing migraine headache symptoms. Utilizing IgG food sensitivity testing to create customisable dietary recommendations for patients may allow healthcare providers to treat migraine headaches without the use of medications.
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Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial.
Babapour, M, Khorvash, F, Rouhani, MH, Ghavami, A, Ghasemi-Tehrani, H, Heidari, Z, Karbasi, M, Moradi, F, Askari, G
Nutrition journal. 2022;21(1):50
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Free full text
Plain language summary
Migraine is considered as an intense unilateral throbbing headache, often accompanied by nausea, vomiting, photophobia and phonophobia, which can be exacerbated by routine physical activity. It has been shown that cytokines levels are altered in migraineurs. Cytokines are inflammatory mediators that can stimulate calcitonin gene-related peptide (CGRP) [amino acid] transcription. The aim of this study was to investigate the effects of soy isoflavones supplementation on migraine headache characteristics, mental status, quality of life and CGRP concentration in adult women with migraine. This study is a double-blind, placebo-controlled clinic trial. Participants (n=88 women) were randomly assigned to one of the two groups: intervention or placebo groups (1:1). Patients in the intervention group received one tablet containing 50 mg isoflavones. Results indicate that consumption of 50 mg/day soy isoflavones supplementation for 8 weeks led to significant reduction in frequency, duration, and clinical indices of migraine and improved quality of life and CGRP levels. However, severity of migraine headache and mental status including depression, stress and anxiety were not affected by supplementation. Authors conclude that even though their findings were promising, further studies focusing on the mental status dimensions including depression, stress and anxiety are needed.
Abstract
BACKGROUND Literature suggests a relationship between estrogen levels and migraine headache pathogenesis. However, the effect of soy isoflavones on migraine characteristic remains unclear. This study aimed to investigate the effect of soy isoflavones on migraine characteristics and calcitonin gene-related peptide (CGRP) levels in women with migraine. METHODS Eighty-three participants completed a randomized double-blind controlled trial, receiving 50 mg per day soy isoflavones or placebo supplementation for 8 weeks. Migraine severity, migraine days per month, frequency and duration of attacks, mental status, quality of life and serum CGRP levels were measured at baseline and the end of the intervention. Bivariate comparison and intention-to-treat (ITT) were used for analysis. RESULTS Soy isoflavones intake resulted in a significant decrease in mean frequency (-2.36 vs -0.43, P < 0.001), duration (-2.50 vs -0.02, P < 0.001) of migraine attacks and CGRP level (-12.18 ng/l vs -8.62, P = 0.002) in compared to placebo group. Also, a significant improvement was found in quality of life (16.76 vs 2.52, P < 0.001). Although, reduction in the migraine severity and mental status did not reach a statistically significant level (P > 0.05). CONCLUSION soy isoflavones supplementation may be considered as a complementary treatment for women with migraine to improve migraine characteristics and reduce the burden of disease.