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Long COVID and Nutrition - NED Infobite
BANT's scientific NED InfoBites are designed to provide key elements of the latest research using plain language. They provide quick overviews on particular health issues and nutrition topics for a speedy introduction to the science. Visually attractive and easily shareable with clients and social media followers.
2024
Abstract
Emerging evidence and patient testimony suggests that a proportion of individuals testing positive for COVID-19 will experience on-going and long term symptoms, well after the acute infection is over. Long COVID has been defined as symptoms consistent with COVID-19 infection which persist for 12 weeks or longer. Individuals may be affected with extreme fatigue, brain-fog, shortness of breath, chest pain, joint pain, depression and anxiety, tinnitus and more. Given the newness of this condition, there is limited research data, however some interesting reviews are being conducted on the role of nutrition, dietary antioxidants, immune rejuvenation and mitochondrial function.
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Mitochondrial Function and Health - NED Infobite
BANT's scientific NED InfoBites are designed to provide key elements of the latest research using plain language. They provide quick overviews on particular health issues and nutrition topics for a speedy introduction to the science. Visually attractive and easily shareable with clients and social media followers.
2024
Abstract
The function of cellular mitochondria has far reaching effects on human health. This NED Infobite looks at different dietary types and specific antioxidants and their interplay with mitochondrial function, in particular in the relation to metabolic dysregulation and optimal physical performance.
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The NED Journal - Mitochondrial Health, Metabolic Syndrome, Cancer, Brain and Cognition
Issue 1_July 2023. Peer-reviewed expert reviews and clinical insights from the Nutrition Evidence Editorial Board and Expert Review Panel
2024
Abstract
In this 1st edition of the NED Journal, you can read some of the latest expert insights on mitochondrial health, metabolic syndrome, cancer, and brain health and cognition. Also meet the NED Editorial Board and the members of the Expert Review Panel writing for this issue, with 19 research articles expertly reviewed. The NED Journal transforms the science to enable individualised science-based clinical decision making. It supports BANT members and other integrative and personalised medicine practitioners with their evidence-based practice.
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Leveraging your microbiome for better skin, mood, and brain health, plus why most probiotics suck
Max Lugavere is a health and science journalist, filmmaker, and bestselling author. He is the author of the Genius trilogy of books, including the New York Times bestseller Genius Foods and Genius Kitchen. He hosts The Genius Life podcast, one of the top health and wellness podcasts in the U.S, with an audience of over 1.5 million followers across social media.
2024
Abstract
Kiran Krishnan is a research microbiologist who has been studying the microbiome for over 15 years. Prepare to be astounded as he chats to Max all about the human microbiome, how it makes the human species resilient and adaptable but also how decreasing microbial diversity may in turn lead to reduced resilience, genetic capabilities and a decline in the human species. We are basically eating to feed our microbiome to enable us to survive. They discuss quorum sensing where microbes can influence the overall diversity of species in the gut simply by sensing the signals of other microbes. Plus they debate the drivers of SIBO and how it may not actually be a condition but a symptom of dysfunction within the gut, and the importance of urolithin A for cellular function particularly mitochondria repair and how to cultivate this via our microbes. We know that probiotics can play a key role in promoting the growth of gut bacteria, but what happens in the digestive tract, do they survive? Krishnan delves into the probiotic world and highlights how spore based probiotics have been created to mimic nature and may increase their efficacy.
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How to keep your mitochondria healthy for better energy
Dr Ruscio is a Doctor of Natural Medicine, Doctor of Chiropractic, clinical researcher and author. His podcast, Dr Ruscio Radio presents cutting edge information in health, nutrition and functional medicine distilled into practical advice that can be used to improve our health.
2023
Abstract
Dr Ruscio chats to Ari Whitten to unpack mitochondrial health, introducing the concept that mitochondria are not just energy producers but are also involved in cellular defence, protecting the body by dialling down energy production if they feel threatened. Subsequently, intervening upstream with implementation of diet and lifestyle changes may help shut off this defence response so that mitochondria can focus on energy production. They review the myriad of connections between nutrition, lifestyle factors and mitochondrial function, including body composition/fat, gut health, blood sugar regulation, and sleep (particularly circadian rhythm and melatonin). Mitochondrial testing and supplementation are discussed, as well as fasting to support mitochondrial health, and ways to potentially mitigate mitochondrial loss with ageing via hormetic stress.
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Mitochondria in health and disease
Alex Manos is one of the UK’s leading Functional Medicine practitioners who specialises in SIBO and gut-related disorders, as well as mould illness and mycotoxins. He is also very passionate about physical therapy, movement, resiliency, life coaching, nutritional therapy, and biohacking. He is a lecturer at various colleges and institutions including the Institute of Optimum Nutrition (ION) and on the MSc program at The Centre For Nutritional Education and Lifestyle Management (CNELM).
2023
Abstract
An enlightening conversation between Alex and Ray Griffiths about the importance of mitochondria in health and disease, to the extent that Ray has written a whole book on this topic. They delve into the mechanisms and explore how mitochondria orchestrate numerous processes in our cells and not just energy production. They discuss mitochondrial dysfunction and ways to support mitochondria including potential functional laboratory testing options. Ray believes that as practitioners, we should be looking at the research to see how mitochondria may be involved in the pathophysiology of any health condition that we are presented with, such is their key role as environmental sensors in the body.
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Fasting and Mitochondrial Health
As the pioneer and global leader of Functional Medicine, the Institute of Functional Medicine leads and catalyses the efforts of a large and expanding Functional Medicine ecosystem, including providers, educators, payers, industry leaders, regulators, and influencers.
2023
Abstract
The IFM provides a concise summary of fasting and its impact on mitochondrial health, exploring fasting intervention types and the mechanism of action of two key players mediating mitochondria biogenesis: PGC-1 alpha and NrF2.
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Effects of exercise intensity on gut microbiome composition and function in people with type 2 diabetes.
Torquati, L, Gajanand, T, Cox, ER, Willis, CRG, Zaugg, J, Keating, SE, Coombes, JS
European journal of sport science. 2023;23(4):530-541
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Plain language summary
While it is well known that gut microbiome composition is both inherited and mostly modulated by diet, emerging evidence suggests regular exercise is associated with higher microbial diversity and health promoting taxa. The aim of this study was to examine whether different intensities of exercise exert differential effects on gut microbiome composition and function in low-active people with type 2 diabetes (T2D). This study was a sub-study of the Exercise for Type 2Diabetes (E4D) Study. Fourteen participants volunteered for this sub-study and were randomised into one of the two exercise groups. Results showed that: - in low active people with T2D, moderate intensity, longer duration exercise resulted in increased Bifidobacterium and Escherichia genera, A. municiphila, and butyrate-producing taxa from orders Lachnospirales and Clostridium Cluster IV. - higher intensity exercise also increased butyrate producers, but from different orders (Eryspelothrichales and Oscillospirales), and less investigated species (M.smithii, Negativibacilli spp). - there were no changes in gut microbiome metabolites (short-chain fatty acids). Authors concluded that over an 8-week training intervention, exercise intensity had differing effects on the abundance of specific gut microbiome taxa and function in low active people with T2D.
Abstract
Exercise is positively associated with higher microbial diversity, but there is limited information on exercise intensity's effect on gut microbiome composition and function in clinical populations. This study examines whether different intensities of exercise exert differential effects on gut microbiome composition and function in low active people with type 2 diabetes. This is a sub-study of the Exercise for Type 2 Diabetes Study, a single centre, prospective, randomised controlled trial. Participants (n = 12) completed 8-weeks of combined aerobic and resistance moderate intensity continuous training (C-MICT) or combined aerobic and resistance high-intensity interval training (C-HIIT). Faecal samples were collected before and after intervention to measure gut microbiome composition and metabolic pathways (metagenome shotgun sequencing) and short-chain fatty acids. Post-exercise α-diversity was different between groups as was the relative abundance of specific taxa was (p < .05). Post-exercise relative abundance of Bifidobacterium, A. municiphila, and butyrate-producers Lachnospira eligens, Enterococcus spp., and Clostridium Cluster IV were higher at lower exercise intensity. Other butyrate-producers (from Eryspelothrichales and Oscillospirales), and methane producer Methanobrevibacter smithii were higher at higher exercise intensity. Pyruvate metabolism (ko00620),COG "Cell wall membrane envelope biogenesis" and "Unknown function" pathways were significantly different between groups and higher in C-MICT post-exercise. Differential abundance analysis on KO showed higher expression of Two-component system in C-HIIT. Transcription factors and "unknown metabolism" related pathways decreased in both groups. There were no significant between group changes in faecal short chain fatty acids. Exercise intensity had a distinct effect on gut microbiome abundance and metabolic function, without impacting short-chain fatty acid output.HighlightsEvidence of exercise effect on gut microbiome outcomes is limited to healthy and athletic populationsIn low active people with type 2 diabetes, different exercise intensities increased specific health promoting and butyrate producers species, and showed differentially abundant gut microbiome metabolic pathways.Further investigation is warranted, and if this supports the present findings, then specific exercise intensities may be promoted to target specific species and optimise gut health.
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Sleep deprivation: a deeper dive into clinical screenings, mitochondrial impact, and therapeutic interventions
As the pioneer and global leader of Functional Medicine, the Institute of Functional Medicine leads and catalyses the efforts of a large and expanding Functional Medicine ecosystem, including providers, educators, payers, industry leaders, regulators, and influencers.
2023
Abstract
A concise but informative article from the IFM summarising the importance of sleep for our health with a particular focus on mitochondria. An exploration of the connection between sleep deprivation and oxidative stress, and the role of our circadian clock. Nutrition, exercise, and mind-body therapies are reviewed as potential levers to improve sleep quality and protect against mitochondrial oxidative damage.
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The Functional Medicine Approach to Ending Migraine
Dr. Mark Hyman is a practicing family physician and an internationally recognised leader, speaker, educator, and advocate in the field of Functional Medicine. He is the founder and director of The UltraWellness Centre, the Head of Strategy and Innovation of the Cleveland Clinic Centre for Functional Medicine, a thirteen-time New York Times bestselling author, and Board President for Clinical Affairs for The Institute for Functional Medicine.
2022
Abstract
The causes of migraine appear to be multifactorial and can manifest in many different ways, so the importance of evaluating migraines from a Functional Medicine (FM) perspective to identify potential imbalances in the body is pivotal. Dr Mark Hyman speaks to Dr Todd LePine, an Institute for Functional Medicine Certificated Practitioner to discuss how to identify and eliminate migraines and the differences between the conventional and FM approach. They review the connection between migraines and gut health, nutrient deficiencies such as magnesium, histamine sensitivity, genetics, the role of mitochondria and also lifestyle factors such as sleep and stress which can exacerbate symptoms. Exploring dietary and sleeping patterns and stress exposure/management appears to be key for first line migraine prevention. However they also review functional testing that may be helpful to identify the root cause, and supplementing with Magnesium, CoQ10, and Vitamin B2.