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Cerebral venous thrombosis, neutropenia and iron-deficiency anemia in Huntington disease.
Tabibian, F, Adibi, I, Ardestani, PE, Tabibian, E, Akbaripour, S, Bürk, K
Neurodegenerative disease management. 2021;(2):137-142
Abstract
Neurologic and nonneurologic manifestations have been shown for Huntington disease (HD) as a genetic neurodegenerative disorder. However, cerebral venous thrombosis (CVT), iron-deficiency anemia and neutropenia have not been reported as its presentations to date. We introduce the first case of a HD patient with CVT, iron-deficiency anemia and neutropenia. All transient and chronic risk factors for development of these manifestations were ruled out. According to the experimental evidences reviewed in this article, we suggest that HD itself could promote formation of CVT, iron-deficiency anemia and neutropenia through vascular and blood cell abnormalities.
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2.
Deferasirox Might Be Effective for Microcytic Anemia and Neurological Symptoms Associated with Aceruloplasminemia: A Case Report and Review of the Literature.
Miyake, Z, Nakamagoe, K, Yoshida, K, Kondo, T, Tamaoka, A
Internal medicine (Tokyo, Japan). 2020;(14):1755-1761
Abstract
The patient was a 64-year-old man presented with difficulty in walking, articulation, and swallowing, as well as cognitive impairment. He had refractory microcytic anemia and diabetes mellitus. His serum levels of iron, copper, and ceruloplasmin were low. Magnetic resonance imaging suggested iron deposition in the basal ganglia, thalami, cerebellar dentate nuclei, and cerebral and cerebellar cortices. He was diagnosed with aceruloplasminemia after a ceruloplasmin gene analysis. Iron chelation therapy with deferasirox improved his anemia and cerebellar symptoms, which included dysarthria and limb ataxia. The present study and previous reports indicate that cerebellar symptoms with aceruloplasminemia might respond to deferasirox in less than one year.
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3.
Gastric Inflammatory Fibroid Polyp: A Rare Cause of Occult Upper Gastrointestinal Bleeding.
Inayat, F, Ur Rahman, A, Wahab, A, Riaz, A, Zahid, E, Bejarano, P, Pimentel, R
Journal of investigative medicine high impact case reports. 2020;:2324709620936840
Abstract
Inflammatory fibroid polyps (IFPs) are rare mesenchymal lesions that can arise throughout the gastrointestinal tract. These tumors represent less than 0.1% of all gastric polypoid lesions and are frequently found incidentally on endoscopic evaluation. While presenting symptoms depend on the location of the tumor, gastric polyps commonly present with epigastric pain and early satiety. We hereby delineate the case of a middle-aged female who presented with chronic iron deficiency anemia and a positive fecal occult blood test. She underwent an upper endoscopy, which revealed an actively oozing umbilicated lesion in the gastric antrum. Endoscopic ultrasound divulged the submucosal origin of the lesion. It was subsequently excised using endoscopic mucosal resection. Pathologic examination of the resected specimen confirmed the diagnosis of gastric IFP. Furthermore, we conducted a systematic literature search of the MEDLINE database centered on gastric IFPs from January 2000 till March 2020. The data on patient demographics, clinical features, endoscopic findings, lesion site and size, and treatment approaches were collected and analyzed. This article illustrates the overarching need for clinicians to be vigilant of gastric IFPs presenting with initial clinical symptoms suggestive of occult upper gastrointestinal bleeding. Prompt diagnosis and management of gastric IFPs carry paramount importance to combat chronic unexplained iron deficiency anemia following occult bleeding in such patients. A concoction of endoscopy, biopsy, and immunohistochemical examination can be employed toward their prompt detection. Although gastric IFPs have conventionally been treated with surgery, endoscopic resection is now emerging as a safe and efficient therapeutic modality.
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4.
Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation.
Greil, J, Verga-Falzacappa, MV, Echner, NE, Behnisch, W, Bandapalli, OR, Pechanska, P, Immenschuh, S, Vijayan, V, Balla, J, Tsukahara, H, et al
Haematologica. 2016;(11):e436-e439
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5.
A novel tri-allelic mutation of TMPRSS6 in iron-refractory iron deficiency anaemia with response to glucocorticoid.
Nie, N, Shi, J, Shao, Y, Li, X, Ge, M, Huang, J, Zhang, J, Huang, Z, Li, D, Zheng, Y
British journal of haematology. 2014;(2):300-3
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6.
[Hereditary Hemorrhagic Telangiectasia with iron-deficiency anemia: a case report and literature review].
Zhang, LN, Zhang, L, Liu, XF
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 2012;(11):916
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7.
Cameron lesions: unusual cause of gastrointestinal bleeding and anemia.
Maganty, K, Smith, RL
Digestion. 2008;(3-4):214-7
Abstract
Cameron lesions are linear gastric ulcers or erosions on the mucosal folds at the diaphragmatic impression in patients with a large hiatal hernia. The clinical relevance of Cameron lesions is due to their potential complications such as gastrointestinal bleeding (acute, chronic and obscure) and anemia. The diagnosis is usually made during upper endoscopy. Medical therapy is the mainstay of treatment with few cases reserved for surgical correction.
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8.
An unusual case of severe iron deficiency anaemia.
Schnuelle, P, Oberheiden, T, Hohenadel, D, Gottmann, U, Benck, U, Nebe, T, Krammer, HJ, van der Woude, FJ, Birck, R
Gut. 2006;(7):1060
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9.
Iron deficiency and thrombosis: literature review.
Keung, YK, Owen, J
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2004;(4):387-91
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Abstract
Compared to primary thrombocytosis such as that caused by essential thrombocytosis, reactive thrombocytosis is generally regarded as benign. However, reactive thrombocytosis has infrequently been reported to cause severe and even fatal complications. Two fatal cases of reactive thrombocytosis and iron deficiency anemia associated with peripheral/pulmonary vascular and cerebrovascular thrombosis are described. The literature on thrombosis and reactive thrombocytosis associated with iron deficiency anemia is reviewed.
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10.
[Watermelon stomach: a rare cause of iron deficiency anemia, surgically treatable; a new case with review of the literature].
Blanc, P, Phelip, JM, Bertolino, JG, Atger, J, Roblin, X
Annales de chirurgie. 2003;(7):462-4
Abstract
The authors report a new case of water-melon stomach, without portal hypertension, and responsible for a iron deficiency anemia cured by antrectomy. Water-melon stomach is a particular form of gastric antral vascular ectasia, characterized by a specific and striking endoscopic aspect. The diagnostic, histologic, pathogenic and therapeutic aspects are reviewed.