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Bexarotene is a new treatment option for lymphomatoid papulosis.
Krathen, RA, Ward, S, Duvic, M
Dermatology (Basel, Switzerland). 2003;(2):142-7
Abstract
BACKGROUND Lymphomatoid papulosis (LyP) is a clonal T cell proliferation with large cell histology, a chronic course, and an increased risk of lymphoma. Bexarotene (Targretin) is an RXR-selective retinoid (rexinoid) approved for the cutaneous manifestations of cutaneous T cell lymphoma. OBJECTIVE To determine whether bexarotene is effective in treating LyP. METHODS Ten patients with chronic and symptomatic LyP were prospectively treated with oral (n = 3) or topical gel (n = 7) formulations of bexarotene. RESULTS A favorable response to bexarotene treatment with decreased numbers or duration of lesions was seen in all with objective responses in 8 patients. CONCLUSIONS Bexarotene may be an effective palliative treatment for LyP, warranting further controlled studies.