-
1.
Synthesis and modification of bio-derived antibacterial Ag and ZnO nanoparticles by plants, fungi, and bacteria.
Alavi, M, Nokhodchi, A
Drug discovery today. 2021;(8):1953-1962
Abstract
Ag and ZnO nanoparticles (NP) can be prepared by physical, chemical, or eco-friendly methods. The biosynthesis of metal and metal oxide NPs by plants, fungi, and bacteria could be a promising way to obtain biocompatible NPs that have desirable antibacterial activities. However, the uniformity of shape, size, and size distribution of NPs are crucial to producing significant antibacterial results, particularly in physiological conditions such as infected wounds or septicemia. In this review, we discuss recent progress and challenges in the use of novel approaches for the biosynthesis of Ag and ZnO nanoparticles that have antibacterial activities.
-
2.
Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells.
Wang, Z, Tang, M
Journal of applied toxicology : JAT. 2021;(5):683-700
Abstract
Metal oxide nanoparticles present stable and unique performance that makes them suitable for various biomedical applications. There are four common exposure ways that nanoparticles enter our body: injection, inhalation, skin penetration, and ingestion. Among them, injection, ingestion, and skin routes may become significant ways for nano-scale treatment and cosmetics, and inhalation is the essential way for occupational exposure. All those nanoparticles could pass through the exposure routes and enter the circulation, which could cause damage on the cardiovascular system. So it is necessary to evaluate the toxicity of metal oxide nanoparticles and to explore the mechanism. This review chose four commonly used nanometal oxides to discuss about the toxicity they produced, the function they affected, and the mechanisms on cardiovascular endothelial cells. First, we discussed the toxicity they caused. These nanoparticles are less toxic when applied in low doses, but owing to the small particle size and large specific surface area, acute exposure or the metal ions released by nanoparticles will lead to phenotypic changes of endothelial cells, oxidative stress, and apoptosis. An endothelial cell is an essential part of blood vessels and could act as a barrier, maintain vascular tension, and keep the balance between coagulation and anticoagulation. Once vascular endothelium is injured or exposed to vascular risk factors, it would cause endothelial activation, endothelial dysfunction, and nitric oxide (NO) synthase (NOS) dysfunction, which are closely related to the cardiovascular disease. Finally, we talked about the mechanisms by four levels, and we especially mentioned inflammation, the production of reactive oxygen species, and NO.
-
3.
Recent progress in materials development and biological properties of GTR membranes for periodontal regeneration.
Ul Hassan, S, Bilal, B, Nazir, MS, Naqvi, SAR, Ali, Z, Nadeem, S, Muhammad, N, Palvasha, BA, Mohyuddin, A
Chemical biology & drug design. 2021;(6):1007-1024
Abstract
Chronic periodontal is a very common infection that instigates the destruction of oral tissue, and for its treatment, it is necessary to minimize the infection and the defects regeneration. Periodontium consists of four types of tissues: (a) cementum, (b) periodontal ligament, (c) gingiva, and 4) alveolar bone. In separated cavities, regenerative process also allows various cell proliferations. Guided tissue regeneration (GTR) is a potential procedure that favors periodontal regrowth; however, some limitations (such as ineffective hemostatic property, poor mechanical property, and improper biodegradation) are also associated with it. This review mainly emphasizes on the following areas: (a) a summarized overview of the periodontium and its immunological situations, (b) recently utilized treatments for regeneration of distinctive periodontal tissues; (c) an overview of GTR membranes available commercially, and the latest developments on the characterization and processing of GTR membrane material; and 4) the function of the different non-polymeric/polymeric materials, which are acting as drug carriers, antibacterial agents, nanoparticles, and periodontal barrier membranes to prevent periodontal inflammation and to improve the strength of the GTR membrane.
-
4.
Metal-based nanoparticles, sensors, and their multifaceted application in food packaging.
Kumar, A, Choudhary, A, Kaur, H, Mehta, S, Husen, A
Journal of nanobiotechnology. 2021;(1):256
Abstract
Due to the global rise of the human population, one of the top-most challenges for poor and developing nations is to use the food produces safely and sustainably. In this regard, the storage of surplus food (and derived products) without loss of freshness, nutrient stability, shelf life, and their parallel efficient utilization will surely boost the food production sector. One of the best technologies that have emerged within the last twenty years with applications in the packaging of food and industrial materials is the use of green mode-based synthesized nanoparticles (NPs). These NPs are stable, advantageous as well as eco-friendly. Over the several years, numerous publications have confirmed that these NPs exert antibacterial, antioxidant, and antifungal activity against a plethora of pathogens. The storage in metal-based NPs (M-NPs) does not hamper the food properties and packaging efficiency. Additionally, these M-NPs help in the improvement of properties including freshness indicators, mechanical properties, antibacterial and water vapor permeability during food packaging. As a result, the nano-technological application facilitates a simple, alternate, interactive as well as reliable technology. It even provides positive feedback to food industries and packaging markets. Taken together, the current review paper is an attempt to highlight the M-NPs for prominent applications of antimicrobial properties, nanosensors, and food packaging of food items. Additionally, some comparative reports associated with M-NPs mechanism of action, risks, toxicity, and overall future perspectives have also been made.
-
5.
Applications of chitosan and chitosan based metallic nanoparticles in agrosciences-A review.
Chouhan, D, Mandal, P
International journal of biological macromolecules. 2021;:1554-1569
Abstract
The second most abundant biological macromolecule, next to cellulose is Chitosan. It is a versatile naturally occurring hydrophilic polysaccharide, derived as a deacetylated form of chitin. Due to its biocompatibility, biodegradability and antimicrobial activity, it has become a significant area of research towards drug delivery system, plant growth promotion, anti-pathogenic potentiality, seed priming and in plant defense mechanism. Various synthetic strategies have been established in recent years that couples different metals with chitosan nanoparticles. Metals like silver, copper, zinc, iron and nickel are highly compatible to form chitosan metallic nanoparticles and are proved to be non-toxic to the agricultural plant system. This review highlights the mode of action of nanochitosan on Gram-positive and Gram-negative bacteria in a distinguished manner as well as its action on fungi. A prime focus has been given on the skeletal framework of the metallic nanochitosan particles. Our study also projects the antimicrobial mechanism of chitosan based on its physiochemical properties, environmental factors and the type of organism on which it acts. Moreover, the mechanism for stimulation of plant immunity by metallic nanochitosan has also been reviewed. Our study relies on the conclusion that chitosan metallic nanoparticles showed enhanced anti-pathogenic and plant growth promoting activity in comparison to bulk chitosan.
-
6.
Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases.
Younis, NK, Ghoubaira, JA, Bassil, EP, Tantawi, HN, Eid, AH
Nanomedicine : nanotechnology, biology, and medicine. 2021;:102433
Abstract
Cardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to their special properties, iron oxide, gold and silver nanoparticles (NPs) could exert various effects in the management and treatment of CVD. The role of iron oxide NPs in the detection and identification of atherosclerotic plaques is receiving increased attention. Moreover, these NPs enhance targeted stem cell delivery, thereby potentiating the regenerative capacity at the injured sites. In addition to their antioxidative and antihypertrophic capacities, gold NPs have also been shown to be useful in the identification of plaques and recognition of inflammatory markers. Contrary to first reports suggestive of their cardio-vasculoprotective role, silver NPs now appear to exert negative effects on the cardiovascular system. Indeed, these NPs appear to negatively modulate inflammation and cholesterol uptake, both of which exacerbate atherosclerosis. Moreover, silver NPs may precipitate bradycardia, conduction block and sudden cardiac death. In this review, we dissect the cellular responses and toxicity profiles of these NPs from various perspectives including cellular and molecular ones.
-
7.
Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy.
Lachowicz, JI, Lecca, LI, Meloni, F, Campagna, M
Molecules (Basel, Switzerland). 2021;(21)
Abstract
An increasing number of pathologies correlates with both toxic and essential metal ions dyshomeostasis. Next to known genetic disorders (e.g., Wilson's Disease and β-Thalassemia) other pathological states such as neurodegeneration and diabetes are characterized by an imbalance of essential metal ions. Metal ions can enter the human body from the surrounding environment in the form of free metal ions or metal-nanoparticles, and successively translocate to different tissues, where they are accumulated and develop distinct pathologies. There are no characteristic symptoms of metal intoxication, and the exact diagnosis is still difficult. In this review, we present metal-related pathologies with the most common onsets, biomarkers of metal intoxication, and proper techniques of metal qualitative and quantitative analysis. We discuss the possible role of drugs with metal-chelating ability in metal dyshomeostasis, and present recent advances in therapies of metal-related diseases.
-
8.
Polymer Nanocomposites of Selenium Biofabricated Using Fungi.
Tsivileva, O, Pozdnyakov, A, Ivanova, A
Molecules (Basel, Switzerland). 2021;(12)
Abstract
Nanoparticle-reinforced polymer-based materials effectively combine the functional properties of polymers and unique characteristic features of NPs. Biopolymers have attained great attention, with perspective multifunctional and high-performance nanocomposites exhibiting a low environmental impact with unique properties, being abundantly available, renewable, and eco-friendly. Nanocomposites of biopolymers are termed green biocomposites. Different biocomposites are reported with numerous inorganic nanofillers, which include selenium. Selenium is a micronutrient that can potentially be used in the prevention and treatment of diseases and has been extensively studied for its biological activity. SeNPs have attracted increasing attention due to their high bioavailability, low toxicity, and novel therapeutic properties. One of the best routes to take advantage of SeNPs' properties is by mixing these NPs with polymers to obtain nanocomposites with functionalities associated with the NPs together with the main characteristics of the polymer matrix. These nanocomposite materials have markedly improved properties achieved at low SeNP concentrations. Composites based on polysaccharides, including fungal beta-glucans, are bioactive, biocompatible, biodegradable, and have exhibited an innovative potential. Mushrooms meet certain obvious requirements for the green entity applied to the SeNP manufacturing. Fungal-matrixed selenium nanoparticles are a new promising biocomposite material. This review aims to give a summary of what is known by now about the mycosynthesized selenium polymeric nanocomposites with the impact on fungal-assisted manufactured ones, the mechanisms of the involved processes at the chemical reaction level, and problems and challenges posed in this area.
-
9.
Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics.
Mauro, N, Utzeri, MA, Varvarà, P, Cavallaro, G
Molecules (Basel, Switzerland). 2021;(11)
Abstract
Cancer theranostics is a new concept of medical approach that attempts to combine in a unique nanoplatform diagnosis, monitoring and therapy so as to provide eradication of a solid tumor in a non-invasive fashion. There are many available solutions to tackle cancer using theranostic agents such as photothermal therapy (PTT) and photodynamic therapy (PDT) under the guidance of imaging techniques (e.g., magnetic resonance-MRI, photoacoustic-PA or computed tomography-CT imaging). Additionally, there are several potential theranostic nanoplatforms able to combine diagnosis and therapy at once, such as gold nanoparticles (GNPs), graphene oxide (GO), superparamagnetic iron oxide nanoparticles (SPIONs) and carbon nanodots (CDs). Currently, surface functionalization of these nanoplatforms is an extremely useful protocol for effectively tuning their structures, interface features and physicochemical properties. This approach is much more reliable and amenable to fine adjustment, reaching both physicochemical and regulatory requirements as a function of the specific field of application. Here, we summarize and compare the most promising metal- and carbon-based theranostic tools reported as potential candidates in precision cancer theranostics. We focused our review on the latest developments in surface functionalization strategies for these nanosystems, or hybrid nanocomposites consisting of their combination, and discuss their main characteristics and potential applications in precision cancer medicine.
-
10.
Recent insights into the impact, fate and transport of cerium oxide nanoparticles in the plant-soil continuum.
Prakash, V, Peralta-Videa, J, Tripathi, DK, Ma, X, Sharma, S
Ecotoxicology and environmental safety. 2021;:112403
Abstract
The advent of the nanotechnology era offers a unique opportunity for sustainable agriculture provided that the exposure and toxicity are adequately assessed and properly controlled. The global production and application of cerium oxide nanoparticles (CeO2-NPs) in various industrial sectors have tremendously increased. Most of the nanoparticles end up in water and soil where they interact with soil microorganisms and plants. Investigating the uptake, translocation and accumulation of CeO2-NPs is critical for its safe application in agriculture. Plant uptake of CeO2-NPs may lead to their accumulation in different plant tissues and interference with key metabolic processes of plants. Soil microbes can also be affected by increasing CeO2-NPs in soil, leading to changes in the physiology and enzymatic activity of soil microorganisms. The interactions between CeO2-NPs, microbes and plants in the agricultural system need systemic research in ecologically relevant conditions. In the present review, The uptake pathways and in-planta translocation of CeO2-NPs,and their impact on plant morphology, nutritional values, antioxidant enzymes and molecular determinants are presented. The role of CeO2-NPs in modifying soil microbial community in plant rhizosphere is also discussed. Overall, the review aims to provide a comprehensive account on the behaviour of CeO2-NPs in soil-plant systems and their potential impacts on the soil microbial community and plant health.