1.
Removal of antibiotics from aqueous solutions by nanoparticles: a systematic review and meta-analysis.
Malakootian, M, Yaseri, M, Faraji, M
Environmental science and pollution research international. 2019;(9):8444-8458
Abstract
Antibiotics, as one of the emerging pollutants, are non-biodegradable compounds and long-term exposure to them may affect endocrine, hormonal, and genetic systems of human beings, representing a potential risk for both the environment and human health. The presence of antibiotics in surface waters and drinking water causes a global health concern. Many researches have stated that conventional methods used for wastewater treatment cannot fully remove antibiotic residues, and they may be detected in receiving waters. It is reported that nanoparticles could remove these compounds even at low concentration and under varied conditions of pH. The current study aimed to review the most relevant publications reporting the use of different nanoparticles to remove antibiotics from aqueous solutions. Moreover, meta-analysis was conducted on the results of some articles. Results of meta-analysis proved that different nanoparticles could remove antibiotics with an acceptable efficiency of 61%. Finally, this review revealed that nanoparticles are promising and efficient materials for degradation and removal of antibiotics from water and wastewater solutions. Furthermore, future perspectives of the new generation nanostructure adsorbents were discussed in this study.
2.
Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review.
Muhamad, N, Plengsuriyakarn, T, Na-Bangchang, K
International journal of nanomedicine. 2018;:3921-3935
Abstract
Patients treated with conventional cancer chemotherapy suffer from side effects of the drugs due to non-selective action of chemotherapeutic drugs to normal cells. Active targeting nanoparticles that are conjugated to targeting ligands on the surface of nanoparticles play an important role in improving drug selectivity to the cancer cell. Several chemotherapeutic drugs and traditional/herbal medicines reported for anticancer activities have been investigated for their selective delivery to cancer cells by active targeting nanoparticles. This systematic review summarizes reports on this application. Literature search was conducted through PubMed database search up to March 2017 using the terms nanoparticle, chemotherapy, traditional medicine, herbal medicine, natural medicine, natural compound, cancer treatment, and active targeting. Out of 695 published articles, 61 articles were included in the analysis based on the predefined inclusion and exclusion criteria. The targeting ligands included proteins/peptides, hyaluronic acid, folic acid, antibodies/antibody fragments, aptamer, and carbohydrates/polysaccharides. In vitro and in vivo studies suggest that active targeting nanoparticles increase selectivity in cellular uptake and/or cytotoxicity over the conventional chemotherapeutic drugs and non-targeted nanoparticle platform, particularly enhancement of drug efficacy and safety. However, clinical studies are required to confirm these findings.