1.
Nicorandil-induced oral ulceration: report of 3 cases and review of the Japanese literature.
Yamamoto, K, Matsusue, Y, Horita, S, Minamiguchi, M, Komatsu, Y, Kirita, T
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2011;(6):754-9
Abstract
Nicorandil-induced oral ulceration in 3 Japanese patients is reported. The patients were men aged 86, 81, and 91 years. Ulcers of 15, 10, and 12 mm in diameter, respectively, were observed at the border of all of the patients' tongues. These were painful and persistent but not indurated. Irritation by the teeth or dentures was not evident. They had been administered nicorandil at a dose of 15 mg for 22, 54, and 90 months, respectively; therefore, ulceration induced by nicorandil was suspected. In consultation with the doctor, nicorandil was withdrawn. The ulcers disappeared 5, 8, and 9 weeks, respectively, after the cessation of nicorandil. No relapse of the ulcer was noted. The findings suggest that these were the examples of nicorandil-induced oral ulceration.
2.
Nicorandil induced perianal ulceration.
Tiernan, JP, Baraza, W, Chelham, W, Garner, J, Angel, C, Shrestha, BM
JNMA; journal of the Nepal Medical Association. 2009;(175):239-41
Abstract
Nicorandil is a cardioprotective drug which is used in the prophylaxis and long-term treatment of angina pectoris. Debilitating perianal ulcer is a rare complication of Nicorandil therapy which can cause diagnostic and management dilemmas. We describe the management of a case of Nicorandil-induced perianal ulcer and review pertinent contemporary literature.
3.
Major aphthous ulcers induced by nicorandil.
Gupta, A, Morris, G
Age and ageing. 2000;(4):372-3