1.
Preoperative Risk Assessment and Management in Adults Receiving Maintenance Dialysis and Those With Earlier Stages of CKD.
Bahrainwala, JZ, Gelfand, SL, Shah, A, Abramovitz, B, Hoffman, B, Leonberg-Yoo, AK
American journal of kidney diseases : the official journal of the National Kidney Foundation. 2020;(2):245-255
Abstract
With an increasingly aging population and improved mortality in individuals with end-stage kidney disease, more surgeries are being performed on patients with all stages of chronic kidney disease (CKD). This high-risk population carries unique risk factors that have been associated with increased adverse perioperative outcomes, including acute kidney injury, cardiovascular events, and mortality. In this article, we review the literature describing absolute risks associated with common surgeries performed in patients with CKD and patients receiving maintenance dialysis. We also review perioperative optimization with special risk assessment including evaluation of cardiovascular and bleeding risk evaluation, hypertension management, and timing of dialysis. Predictive model scores are reviewed as a method to stratify risk for acute kidney injury, major adverse cardiac events, or other serious complications with elective surgeries. A multidisciplinary approach with individualized counseling is necessary to counsel the patient with advanced CKD or patients treated with maintenance dialysis considering elective surgery.
3.
[Possible genetic link between Darier's disease and depression. Review of the literature and case history].
Bach, DR, Moggi, F, Müller, TJ, Seifritz, E, Strik, WK, Wirtz, G
Der Nervenarzt. 2007;(1):81-4
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Abstract
Darier's disease is a rare, inherited autosomal dominant skin disorder caused by a mutation in the sarcoendoplasmatic reticulum calcium transporter (SERCA)-2-gene. In a number of pedigrees, Darier's disease closely relates with affective disorder. The most likely hypothesis for this is a susceptibility gene for affective disorder near the SERCA-2-gene. A 6.5-megabase region could be identified as a susceptibility locus. This region constitutes a susceptability locus also in affective disorder without Darier's disease. The underlying gene has not yet been identified.
4.
Computed tomography coronary calcium screening and myocardial perfusion imaging.
Raggi, P, Berman, DS
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 2005;(1):96-103
Abstract
Cardiac computed tomography (CT) has seen an exponential increase in interest as applications expanded from identification of coronary artery calcification to noninvasive coronary angiography and, more recently, identification of soft and noncalcified plaques. The interest arises from the well-known fact that cardiovascular disease remains the most prevalent cause of death in the Western hemisphere and the fact that in a large proportion of patients the initial event is either sudden death or a disabling myocardial infarction or stroke. Although traditional risk factors are extremely helpful in determining risk in a population, the prognostic ability of risk factors alone in the individual patient is limited. Hence, researchers have turned their attention to noninvasive modalities to image the atherosclerotic plaque in its preclinical stages, hoping to better address this ailment at its inception and change the natural history of the disease. Measurements of coronary artery calcium (CAC) serve as a quantitative reflection of the severity of coronary artery atherosclerosis, and greater calcium burdens correlate with more advanced disease. Indeed, CAC has been shown to add prognostic value to traditional risk factors in patients at intermediate risk, and in this group of patients, it is most cost-effective. Furthermore, CAC measurements providing an assessment of coronary atherosclerotic plaque burden appear to be complementary to myocardial perfusion single photon emission computed tomography that offers information regarding inducible ischemia. In this manner, a better assessment of risk in a patient suspected of harboring preclinical or early coronary artery disease can be achieved. In this article we review the most relevant literature regarding the utilization of CAC testing as a tool to refine risk assessment and use several case studies to exemplify the combination of CT imaging and functional myocardial perfusion studies, which may provide a better identification of patients in need of aggressive medical therapy and those needing invasive assessment for possible coronary revascularization.