1.
[Bone fracture and the healing mechanisms. Fracture treatment by low-intensity pulsed ultrasound].
Jingushi, S
Clinical calcium. 2009;(5):704-8
Abstract
The principles of fracture treatment are the reduction and fixation of the fracture site, while the subsequent biological healing process is expected. Currently, some treatment options that actively stimulate the repair reaction at the fracture site are either available, or they are soon going to become available for clinical use. Low-intensity pulsed ultrasound (LIPUS) or local growth factors are examples of these modalities. They are non-invasive or less invasive than the previous stimulating options such as bone grafting at the fracture site. These treatment modalities are not only used to heal delayed union or non-union but they also have the potential to shorten the repair period until union is achieved while also reducing complications, including deformity or non-union.
2.
Experimental treatments for acute ischaemic stroke.
Sacco, RL, Chong, JY, Prabhakaran, S, Elkind, MS
Lancet (London, England). 2007;(9558):331-41
Abstract
Treatments for acute ischaemic stroke continue to evolve. Experimental approaches to restore cerebral perfusion include techniques to augment recanalising therapies, including combination of antiplatelet agents with intravenous thrombolysis, bridging therapy of combining intravenous with intra-arterial thrombolysis, and trials of new thrombolytic agents. Trials with MRI selection criteria are underway to expand the window of opportunity for thrombolysis. Sonothrombolysis and novel endovascular mechanical devices to retrieve or dissolve acute cerebral occlusions are being tested. Approaches to improve cerebral perfusion with other devices and induced hypertension are also being considered. Although numerous neuroprotective agents have not shown benefit, trials of hypothermia, magnesium, caffeinol, high doses of statins, and albumin are continuing. The findings of these randomised trials are anticipated to allow improved treatment of patients with acute stroke.