1.
Vitamin E contact allergy: a controversial subject.
Corazza, M, Minghetti, S, Borghi, A, Bianchi, A, Virgili, A
Dermatitis : contact, atopic, occupational, drug. 2012;(4):167-9
Abstract
Although vitamin E has been described as a source of allergic contact dermatitis (ACD), in only a few cases a true sensitization has been confirmed. We describe 2 cases of suspected ACD to vitamin E products. Patch tests and repeated open application tests were performed with the patients' own offending products. Then, patch tests with tocopherol acetate at different concentrations and further patch tests and repeated open application tests with a new sample of the product were carried out. Whereas the first sessions of tests gave positive reactions, the last sessions of tests performed with new samples were negative. Based on these results, we conclude that both our patients probably developed a true vitamin E ACD. However, as vitamin E exerts an anti-inflammatory effect and is an unstable molecule and its allergic potential change during the time, when ACD to vitamin E is tested a bimodal behavior of this molecule may be expected.
2.
Role of vitamin E in rheumatic chorea.
Rawat, MS, Patel, AB, Thete, AR, Bokde, C
Indian journal of pediatrics. 2000;(8):563-6
Abstract
Rheumatic chorea is the sole neurologic manifestation of rheumatic fever. It is a debilitating illness lasting for weeks to months. Drugs like diazepam, haloperidol, chlorpromazine take four to six weeks for functional improvement and can cause serious side effects. The authors investigated the role of Vitamin E in reducing rheumatic chorea. A case series of patients of rheumatic chorea were administered Vitamin E in the dose 50 IU daily for fifteen days. The various clinical signs of rheumatic chorea were scored with MAIMS score (Modified Abnormal Involuntary Movement Scale score) which is used for tardive dyskinesia. No other drug for abnormal movements was used. In all the 4 patients who received vitamin E, there was remarkable change by 7th day and almost complete functional improvement by 14th day. Vitamin E is safer than the conventional drugs used for chorea in children. It was found effective in this case series. Its role needs further evaluation by a double-blind randomized controlled trial.