1.
Effects of Sodium Valproate Monotherapy on Blood Liver Enzyme Levels in Patients with Epilepsy: A Meta-Analysis.
Fu, J, Tao, T, Li, Z, Chen, Y, Chen, X, Li, J, Peng, L
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2021;(7):425-434
Abstract
We conducted this meta-analysis to assess the effects of sodium valproate (VPA) monotherapy on blood liver enzymes in patients with epilepsy. PubMed, Web of Science, EBSCO, Cochrane Library, Wanfang, China national knowledge infrastructure databases were searched. Nine studies were included. Results showed: (1) The overall SMD for blood AST, ALT, and GGT levels of VPA monotherapy group versus control group were 0.70 (95% CI=0.31 to 1.09, Z=3.52, p=0.0004), 0.47 (95% CI=- 0.01 to 0.95, Z=1.91, p=0.06), 0.44 (95% CI=0.29 to 0.60, Z=5.55, p<0.00001), respectively. (2) In subgroup meta-analysis, increased blood AST and GGT levels were observed in epileptic minors (AST: total SMD=0.85, 95% CI=0.40 to 1.30, Z=3.69, p=0.0002; GGT: total SMD=0.46, 95% CI=0.29 to 0.63, Z=5.25, p<0.00001). Elevated blood ALT level was observed in Asian patients receiving VPA monotherapy (total SMD=0.70, 95% CI=0.51 to 0.90, Z=7.01, p<0.00001), and the early stage of VPA monotherapy (total SMD=0.93, 95% CI=0.57 to 1.29, Z=5.09, p<0.00001). Overall, our results indicated that blood AST and GGT were significantly increased in epileptic minors receiving VPA monotherapy. The elevation of blood ALT was observed in Asian patients and the early stage of VPA monotherapy. However, due to the small number of included studies, our results should be considered with caution.
2.
The application experience of all-around nursing care in infantile febrile convulsion.
Jia, L, Cai, Y, Li, W, Chen, X
Minerva pediatrica. 2019;(3):242-246
Abstract
BACKGROUND The aim of this study was to analyze the value of all-around nursing care for infantile febrile convulsion. METHODS Ninety-eight cases diagnosed with infantile febrile convulsion from February 2013 to October 2014 were selected to participate in this study. This study was approved by the hospital's ethics committee and received consent from the patients as well as their families. The patients were divided into a control group (N.=48 cases) and an observation group (N.=50 cases). Patients in both groups were offered anticonvulsants. The control group was offered general nursing care while the observation group was offered all-around nursing care. We compared and analyzed the nursing care in both groups. RESULTS The body temperature recovery and convulsion control time in the observation group were lower than the control group. Remarkably, the convulsion control rate was higher than the control group. The hospital stays were lower in the observation group compared to the control group (P<0.05). The patients' serum potassium, serum sodium levels and blood glucose before nursing care were all in the normal range. However, the serum potassium and serum sodium levels in the control group were lower, and the blood glucose level was higher than previous. After nursing care, the serum potassium and serum sodium levels in the observation group were higher than the control group. The blood glucose level was lower than the control group (P<0.05). The nursing satisfaction in the observation group was higher than the control group. The convulsion recurrence rate was lower in the observation group compared to the control group (P<0.05). CONCLUSIONS The combination of all-around nursing care and anticonvulsants can improve the occurrence and duration of infantile febrile convulsion.