1.
Impact of High-Flux Hemodialysis on Chronic Inflammation, Antioxidant Capacity, Body Temperature, and Immune Function in Patients with Chronic Renal Failure.
Li, S, Li, H, Wang, J, Yin, L
Journal of healthcare engineering. 2022;:7375006
Abstract
In order to probe into the impact of high-flux dialysis and hemodiafiltration on patients with chronic rental failure, this paper selects in total 92 cases with chronic renal failure receiving hemodialysis from November 2018 to July 2021, allocating them into two groups based on the random table, each with 46 cases. The control group received hemodiafiltration, the observation group is given high-flux hemodialysis, and we compared serum inflammatory factor level and antioxidant factor level before and after treatment, as well as cellular immune factor level (CD3+, CD4+) and humoral immune factor level (IgE) before and after treatment in the two groups; the renal function, serum total calcium ion level, and serum phosphorus ion level in the two groups were compared before and after treatment, as well as the proportion of metabolic abnormalities in calcium and phosphorus ion levels during treatment; the trend of changes in axillary temperature during treatment in the two groups is analyzed. After treatment, serum inflammatory factor level (hs-CRP & TNF-α) is lower than that in the control group (P < 0.05), antioxidant factor level (MDA) is lower than that in the control group (P < 0.05), and SOD level is higher than that in the control group (P < 05). After treatment CD3+ and CD4+ levels in the observation group are higher than those in the control group (P < 0.05). For patients with chronic renal failure, high-flux hemodialysis is available to better reduce inflammatory response, improve antioxidant and immune capacity in the body, and help maintain calcium and phosphorus metabolic balance.
2.
Ferroptosis: A Novel Therapeutic Direction of Spinal Cord Injury.
Zhao, Q, Liu, F, Zhou, B, Liu, H, Wang, X, Li, S
Computational and mathematical methods in medicine. 2022;:7906218
Abstract
An injury to the spinal cord results in a crucial central nervous system event that further causes irreversible impairment or loss of motor, autonomic, and sensory functions. A progressive pathophysiological cascade following spinal cord injury (SCI) includes ischemia/reperfusion injury, oxidative stress, proapoptotic signaling, peripheral inflammatory cell infiltration, and glutamate-mediated excitotoxicity, and regulated cell death. These complex pathological and physiological changes continue to cause cell injury over the long-term and severely limit the efficacy of clinical treatment strategies in restoring the injured nervous system. Ferroptosis is a nonapoptotic, iron-regulated kind of cell death that has recently been discovered. It is distinguished by iron overload-induced toxic lipid peroxidation associated with mitochondrial morphological changes during the cell death process. For example, after SCI, iron overload activates the reactive oxygen species generation, dysregulation of glutathione/glutathione peroxidase 4 (GSH/GPX4) metabolism, and accumulation of lipid peroxides, which cause lipid membrane deterioration and ferroptosis. Conversely, knockout or differential expression of key genes and application of lipid peroxidation inhibitors and iron chelators (e.g., deferoxamine) (e.g., SRS-16-86) can block ferroptosis and promote neuronal repair for functional recovery after SCI. Although the findings of numerous investigations have been confirmed the importance of ferroptosis in several human neurologic sicknesses and its potential in SCI, the mechanism of ferroptosis and its application in SCI has not been elucidated. This review highlights current ferroptosis research and its impact on SCI, as well as the key molecular mechanism of ferroptosis in promoting the recovery from SCI. Understanding ferroptosis' process and function in SCI could provide useful insight into the treatment and avoidance of such a destructive injury.
3.
Probiotic Supplement Preparation Relieves Test Anxiety by Regulating Intestinal Microbiota in College Students.
Qin, Q, Liu, H, Yang, Y, Wang, Y, Xia, C, Tian, P, Wei, J, Li, S, Chen, T
Disease markers. 2021;:5597401
Abstract
Test anxiety creates barriers to learning and performance, which further affects students' social, behavioural, and emotional development. Currently, the medication to treat test anxiety has not been reported yet. Here, we enrolled 120 students to evaluate the effect of probiotic supplement preparation (PSP) on test anxiety from the aspect of the intestinal microbiota. We found that the intake of PSP alleviated the symptoms of depression and anxiety in students with test anxiety by evaluating their mental state using the Hamilton Depression Rating Scale and Hamilton Anxiety Scale. High-throughput sequencing results indicated that the consumption of PSP increased the abundance of Streptococcus and Akkermansia that was lowered by the anxiety state in the intestinal microbiota of students. Meanwhile, taking PSP reduced the level of intestinal pathogens of Fusobacterium and Clostridium as well. In conclusion, our work shows that PSP can reduce test anxiety and restore the disturbed microbiota to the standard level in Chinese college students, rendering the use of PSP a promising strategy for test anxiety.
4.
An analysis of factors related to the development of in-stent restenosis after percutaneous coronary intervention.
Zhang, G, Li, S, Lin, P, Chen, Y
Medicine. 2020;(5):e18915
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Abstract
To investigate the relationship between life style, medication adherence and the development of in-stent restenosis after percutaneous coronary intervention.A total of 230 patients with coronary heart disease were recruited and investigated with semi-quantitative food frequency questionnaire, international physical activity questionnaire, screening tool for psychological and Morisky questionnarie. Logistic regression was used for statistical analysis.Logistic regression analysis revealed that there was positive correlation between Morisky score (OR = 1.503), anger (OR = 1.135) and restenosis; and there was negative correlation between physical activity (OR = 0.346), folate intake (OR = 0.926), Vitamin C ingestion (OR = 0.881) and restenosis.The lifestyle and medication adherence of patients after percutaneous coronary intervention are predictors of restenosis, suggesting that it is necessary to strength intervention program to reduce restenosis.