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Does tea extract supplementation benefit metabolic syndrome and obesity? A systematic review and meta-analysis.
Li, X, Wang, W, Hou, L, Wu, H, Wu, Y, Xu, R, Xiao, Y, Wang, X
Clinical nutrition (Edinburgh, Scotland). 2020;(4):1049-1058
Abstract
BACKGROUND Given the global epidemic of obesity, numerous strategies have been employed in the management of metabolic syndrome (MS) in this population. A meta-analysis was designed in the present investigation to evaluate the benefits of tea extract (TE) supplementation in MS in obesity. METHODS We conducted searches of published literature in MEDLINE, PsycINFO, Scopus, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases from inception in 1985 to May 2017. Randomized controlled trials (RCTs) which studied TE consumption in obesity with MS were analyzed. Results were summarized using weighted mean differences (WMDs), standardized mean differences (SMDs) or odds ratio (OR) by suitable effect model. RESULTS Sixteen eligible randomized controlled trials, including 1090 subjects were identified. Benefits were demonstrated on reduction of Body Mass Index (BMI) (SMD, -0.27; 95% CI, -0.40 to -0.15, P < 0.0001) and blood glucose (SMD, -0.22; 95% CI, -0.34 to -0.10, P = 0.0003), and increasing high-density lipoprotein (HDL) (SMD, 0.18; 95% CI, 0.01 to 0.35, P = 0.03). Limited benefits without significance were observed on blood pressure and other anthropometric, cholesterol, and biochemistry outcomes. All-cause adverse events were minimal (0.99; 95% CI: 0.55, 1.77, P = 0.97). CONCLUSIONS This meta-analysis suggests that consumption of TE supplementation in the obese with MS has beneficial effects on improvement of lipid and glucose metabolism, as well as in the facilitation of weight loss.
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Potassium and Obesity/Metabolic Syndrome: A Systematic Review and Meta-Analysis of the Epidemiological Evidence.
Cai, X, Li, X, Fan, W, Yu, W, Wang, S, Li, Z, Scott, EM, Li, X
Nutrients. 2016;(4):183
Abstract
The objective of this study was to investigate the associations between potassium and obesity/metabolic syndrome. We identified eight relevant studies and applied meta-analysis, and nonlinear dose-response analysis to obtain the available evidence. The results of the pooled analysis and systematic review indicated that high potassium intake could not reduce the risk of obesity (pooled OR = 0.78; 95% CI: 0.61-1.01), while serum potassium and urinary sodium-to-potassium ratio was associated with obesity. Potassium intake was associated with metabolic syndrome (pooled OR = 0.75; 95% CI: 0.50-0.97). Nonlinear analysis also demonstrated a protective effect of adequate potassium intake on obesity and metabolic syndrome. Adequate intake of fruits and vegetables, which were the major sources of potassium, was highly recommended. However, additional pertinent studies are needed to examine the underlying mechanism.
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The Effect of Protein-Enriched Meal Replacement on Waist Circumference Reduction among Overweight and Obese Chinese with Hyperlipidemia.
Chen, W, Liu, Y, Yang, Q, Li, X, Yang, J, Wang, J, Shi, L, Chen, Y, Zhu, S
Journal of the American College of Nutrition. 2016;(3):236-44
Abstract
OBJECTIVE In China, high-fat diets and excessive energy intake have led to an increasing prevalence of obesity which was previously uncommon. The current study examined the effects of meal replacement (MR) on weight control in overweight or obese Chinese individuals with hyperlipidemia. METHODS Patients, 18-65 years, with body mass index 25-35 kg/m(2) and triglycerides >1.7 and <5.4 mmol/L were enrolled. Major exclusion criteria were: type II diabetes, fasting glucose ≥7.0 mmol/L, glycosylated hemoglobin ≥6.5%; weight loss surgery or use of weight loss drugs; weight fluctuations >2%; use of cholesterol-lowering drugs. Eligible patients were randomized 1:1 to a high-protein (HP) diet (2.2 g protein/kg/day) or a standard-protein (SP) diet (1.1 g protein/kg/ day) provided twice daily for 3 months. Assessments included body weight, waist-hip ratio, body fat percentage, blood lipids, blood glucose, insulin, liver and kidney function. RESULTS Although mean weight loss and percent BMI reduction were greater with HP than SP at 12 weeks, the differences were not significant. There was, however, a significantly greater decrease in waist-hip ratio with HP versus SP (-0.03 ± 0.03 vs. -0.01 ± 0.04; p < 0.05). Triglycerides decreased from baseline in both groups; however, the difference was not significant. Both HP and SP were well tolerated. This study demonstrated that in obese Chinese patients with hyperlipidemia, a protein-enriched MR diet resulted in significantly reduced waist circumference compared to a standard protein diet. CONCLUSION This first study of protein-enriched partial meal replacement in a free-living Chinese population suggests a new and promising strategy for reducing abdominal obesity in China.
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Weight loss, inflammatory markers, and improvements of iron status in overweight and obese children.
Gong, L, Yuan, F, Teng, J, Li, X, Zheng, S, Lin, L, Deng, H, Ma, G, Sun, C, Li, Y
The Journal of pediatrics. 2014;(4):795-800.e2
Abstract
OBJECTIVE To assess the effect of a weight-loss program on improving iron status in overweight and obese school-aged children. STUDY DESIGN The data were analyzed in overweight and obese children (7-11 years of age; 114 girls and 212 boys) with body mass index-for-age z-scores (BAZ) >1 from a weight-loss program. Schools were randomly divided into 2 groups: intervention and control. Children in the intervention group underwent a 1-year, nutrition-based comprehensive intervention weight-loss program. Anthropometric, dietary intake, and physical activity data were collected at baseline and follow-up (1 year). Iron status and inflammatory markers were assessed within a month. RESULTS In the intervention group, BAZ decreased more than that in the control group (-0.4 ± 0.7 vs -0.1 ± 0.6, P < .0001); and iron profiles and inflammation status were improved at follow-up. In multivariable linear regression models, a greater decrease of BAZ and inflammation factors predicted a better improvement of iron status. After adjustment of ΔBAZ, ΔC-reactive protein was significantly associated with Δserum ferritin (β: 1.89; 95% CI, 0.70-3.09; P = .002) and Δsoluble transferrin receptor (β: 0.88; 95% CI, 0.16-0.59; P = .017); Δinterleukin-6 was significantly associated with Δserum ferritin (β: 1.22; 95% CI, 0.64-1.79; P < .0001). CONCLUSIONS Iron status and inflammation were improved by weight reduction. The improvement in inflammatory markers during weight reduction was independently associated with improvements of iron status.
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Effect of diacylglycerol on body weight: a meta-analysis.
Xu, T, Li, X, Zhang, Z, Ma, X, Li, D
Asia Pacific journal of clinical nutrition. 2008;(3):415-21
Abstract
The effects of diacylglycerol (DAG) on body weight are not consistent in clinical trials. This meta-analysis of randomized controlled trials was conducted to evaluate the efficacy of dietary DAG on body weight. Potential articles were initially searched from the electronic databases of Medline, Embase and Cochrane library using the subject keywords as follows: weight, DAG, triacylglycerol (TAG), reduction and obesity. Inclusion criteria required the trial to be randomized placebo controlled with body weight as an endpoint. Two reviewers independently extracted the information and evaluated the methodological quality using the scoring system developed by Jadad. Meta-analysis was performed with the software of Review Manager 4.2. The robustness of overall analysis was tested by sensitivity analysis and publication bias was visually inspected by funnel plot. Five published trials were included in the statistical pool. The meta-analysis indicated a significant difference in body weight reduction between group receiving DAG and group receiving TAG (weighted mean difference -0.75 kg; 95% CI: -1.11 to -0.39; p < 0.0001). Sensitivity analysis corroborated the result of the overall analysis. Linear regression analysis showed that there was significant correlation between daily dose and body weight reduction (p = 0.044, R2 = 0.889). In conclusion, this meta-analysis suggested that DAG was efficacious for reducing body weight compared with TAG and this effect was influenced by the daily dose.