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Natural sunlight plus vitamin D supplementation ameliorate delayed early motor development in newborn infants from maternal perinatal depression.
Zhang, H, Liu, S, Si, Y, Zhang, S, Tian, Y, Liu, Y, Li, H, Zhu, Z
Journal of affective disorders. 2019;:241-249
Abstract
BACKGROUND Increased cortisol has been shown to be negatively correlated with infant motor development. Sunlight help decrease the level of cortisol. Vitamin D is associated with infant motor development. The present study aimed to determine whether natural sunlight exposure plus vitamin D supplements could ameliorate delayed early motor development in little infants from maternal perinatal depression. METHODS The term pregnant women waiting for delivery from the department of gynecology and obstetrics were assessed depressive symptoms by Hamilton Rating Scale for Depression (HAMD). 120 normal and 229 depressed subjects were recruited. During 2 days postpartum, infant motor development were assessed by Neonatal Behavioral Assessment Scale (NBAS). Infants of 2-day-old in maternal depression group were divided into four groups: control group, conventional vitamin D supplements (400IU/d) group, high dose of vitamin D supplements group (1000IU/d), sunlight plus conventional vitamin D supplement group (400IU/d). Serum and hair cortisol (HairF) in mothers and infants were measured. RESULTS The infants of perinatal depressed mothers displayed early motor developmental delay accompanied by increased cortisol. Sunlight plus conventional vitamin D supplement (400IU/d) were better than exclusive vitamin D supplements for the amelioration delayed early motor development in infants (p < 0.05). The infants exposure to sunlight 7-14 h/week plus conventional vitamin D supplement reached the best scores of motor development and the lowest HairF (p < 0.05). LIMITATIONS We should have measured the serum 25OH-vitamin D concentrations. CONCLUSIONS Sunlight plus vitamin D supplements could ameliorate delayed early motor development in little infants by decreasing cortisol from perinatal depression.
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Effects of early comprehensive interventions on child neurodevelopment in poor rural areas of China: a moderated mediation analysis.
Liu, S, Wang, Z, Zhao, C, Huang, X, Liang, X, Wang, X, Lu, S, Scherpbier, RW
Public health. 2018;:116-122
Abstract
OBJECTIVES To examine the effects of early comprehensive interventions on home environment and child neurodevelopment among children younger than 3 years in poor rural areas of China, as well as the underlying mediating and moderating mechanisms. STUDY DESIGN Non-randomized intervention study was conducted among 216 children aged 0-3 years in Shanxi province of China. Based on a 2 × 2 factor design, children in Lin and Fenxi County were assigned to an intervention group with duration less than 1 year (n = 26) or an intervention group with duration longer than 1 year (n = 82), while children in Fangshan County served as a control group with duration less than 1 year (n = 30) or a control group with duration longer than 1 year (n = 78). METHODS The control group received national public health services (NPHS), while the intervention group received NPHS plus comprehensive interventions covering health, nutrition, early psychosocial stimulation, and child protection. Home environment (Infant-Toddler Home Observation for Measurement of the Environment [HOME]) and child neurodevelopment (Ages and Stages Questionnaire [ASQ]) were measured by observation and interview with mothers after the intervention program. RESULTS The intervention group showed significantly higher overall HOME, organization, learning materials, and involvement than the control group, only for a duration longer than 1 year. Children in the intervention group performed better in overall ASQ, fine motor, problem-solving, and personal-social than children in the control group. Moderated mediation analyses indicated that there were significantly indirect effects of treatment on overall ASQ through overall HOME, organization, and involvement only when the duration was longer than 1 year. CONCLUSIONS Early comprehensive interventions longer than 1 year improve home environment and promote child neurodevelopment among children younger than 3 years in poor rural areas. What is more, effects of early comprehensive interventions longer than 1 year on child neurodevelopment were mediated by home environment.
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Comparison of tripterygium wilfordii multiglycosides and tacrolimus in the treatment of idiopathic membranous nephropathy: a prospective cohort study.
Liu, S, Li, X, Li, H, Liang, Q, Chen, J, Chen, J
BMC nephrology. 2015;:200
Abstract
BACKGROUND Idiopathic membranous nephropathy (IMN) is a major cause of nephrotic syndrome among adults. Considering the natural course of IMN, when to treat and with which immunosuppressive treatment need to be carefully considered in such patients. A combination of tripterygium wilfordii multiglycosides (TWG) and prednisone may be an effective option for treating patients with IMN. METHODS In this prospective cohort study, we enrolled patients with biopsy-proven IMN at our kidney centre. One cohort received TWG combined with prednisone, whereas another cohort received tacrolimus (TAC) combined with prednisone, for 36 weeks. The primary outcome was the remission rate, whereas the secondary outcomes included the time to remission, relapse rate, changes in serum albumin levels and daily urinary protein levels, estimated glomerular filtration rate, and adverse events. RESULTS A total of 53 patients with IMN met the criteria for enrollment, and all patients completed the therapy. At the end of the 36-week therapy, remission (either partial remission [PR] or complete remission [CR]) was observed in 20 patients (86.9 %) receiving TWG and in 27 patients (90.0 %) receiving TAC (p > 0.05), whereas CR was noted in 12 patients (52.2 %) receiving TWG and 14 patients (46.7 %) receiving TAC (p > 0.05). The probability of remission was similar for both the TWG and TAC groups (p > 0.05, by log-bank test). The mean time for achieving remission was 11.8 ± 12.5 weeks in the TWG group and 8.5 ± 9.1 weeks in the TAC group (p > 0.05). CONCLUSIONS The combination of TWG and predisone is an effective and safe therapy for IMN.
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A prospective study of physical activity and risk of prostate cancer in US physicians.
Liu, S, Lee, IM, Linson, P, Ajani, U, Buring, JE, Hennekens, CH
International journal of epidemiology. 2000;(1):29-35
Abstract
BACKGROUND Exercise can suppress androgen production and may thus decrease the risk of prostate cancer. However, findings from epidemiological studies assessing physical activity and risk of prostate cancer are inconsistent. METHODS We prospectively examined the association between physical activity and prostate cancer risk in the Physicians' Health Study (PHS), a randomized trial of low-dose aspirin and beta-carotene among 22,071 men aged 40-84 without self-reported myocardial infarction, stroke and cancer. At baseline in 1982, men were asked about the frequency of exercise vigorous enough to work up a sweat. Physical activity was assessed in a similar fashion again at 36 months of follow-up. RESULTS During 11.1 years of follow-up (258 779 person-years), 982 cases of prostate cancer occurred and were confirmed by medical record review. After adjustment for potential confounding factors (including age, height, randomized treatment assignment, smoking status, alcohol intake, use of multivitamins, history of diabetes, history of hypertension and history of high cholesterol), the relative risks for prostate cancer associated with exercise vigorous enough to work up a sweat were 1.0 (referent) for frequency less than once per week, 1.02 (95% CI: 0.82-1.26) for once per week, 1.07 (95% CI: 0.90-1.27) for 2-4 times per week, and 1.11 (95% CI: 0.90-1.36) for 5+ times per week. Across all subgroups of men categorized by age, body mass index, smoking status, alcohol intake, use of multivitamins, history of diabetes, history of hypertension and history of high cholesterol, there were no significant associations between frequency of exercise vigorous enough to work up a sweat and prostate cancer risk. After excluding cases of prostate cancer that occurred during the first 36 months of follow-up, again, there was no significant association. Combining physical activity assessments at baseline and at 36 months also yielded no significant association with prostate cancer risk. CONCLUSIONS These observational data from the Physicians' Health Study do not support the hypothesis that increased physical activity reduces the risk of prostate cancer.