1.
The G allele of CaSR R990G polymorphism increases susceptibility to urolithiasis and hypercalciuria: evidences from a comprehensive meta-analysis.
Liu, K, Wang, X, Ye, J, Qin, C, Shao, P, Zhang, W, Li, J, Yin, C
BioMed research international. 2015;:958207
Abstract
BACKGROUND The calcium-sensing receptor gene (CaSR) is a candidate to explain urolithiasis. A number of case-control studies were conducted to investigate associations between CaSR polymorphisms with risks of hypercalciuria and urolithiasis in humans. But the results were still inconsistent. METHODS A meta-analysis was performed to address this issue. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of associations between CaSR polymorphisms and the risk of urolithiasis. The pooled standardized mean difference (SMD) with 95% CI was used for the meta-analysis of CaSR polymorphisms and urine calcium concentration. RESULTS For urolithiasis association, the SS genotype of A986S polymorphism was a risk factor for urolithiasis in Asians and PHPT patients, but a protective factor in Caucasians. The GG genotype of R990 polymorphism was associated with an increased risk of urolithiasis, especially in Caucasians and healthy population. Regarding urine calcium concentration association, individuals with the G allele had a higher level of urine calcium than the noncarriers. CONCLUSIONS This meta-analysis revealed that the G allele of CaSR R990G polymorphism increases susceptibility to urolithiasis and hypercalciuria. The A986S and Q1011E polymorphisms were associated with urolithiasis and hypercalciuria in specific populations.
2.
GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis.
Chen, J, Cao, Q, Qin, C, Shao, P, Wu, Y, Wang, M, Zhang, Z, Yin, C
Journal of cancer research and clinical oncology. 2011;(10):1553-61
Abstract
PURPOSE Accumulating evidences implicate the selenium-containing cytosolic glutathione peroxidase, GPx-1, as a determinant of cancer risk and a mediator of the chemopreventive properties of selenium. Since the identification of a well-characterized functional polymorphism named Pro198Leu (rs1050450 C>T) in GPx-1, abundant studies have evaluated the association between Pro198Leu polymorphism and tumor risk in diverse population. But, the available results are conflicting. METHODS To derive a more precise estimation, we performed a meta-analysis based on 14,372 cases with different tumor types and 18,081 controls from 31 published case-control studies. Published literature from PubMed was retrieved. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association. RESULTS Overall, the results indicated that individuals who carried variant Leu allele (Pro/Leu and Leu/Leu) were associated with an increased cancer risk [odds ratio (OR) = 1.12, 95% confidence interval (CI) = 1.02-1.23] in a dominant genetic model. In further subgroup analyses, the increased risk of cancer was observed in subgroup of Asians and sample size more than 500 subjects. CONCLUSION These results suggest that the GPx-1 Pro198Leo polymorphism contributes to cancer susceptibility through a disturbed antioxidant balance.