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Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons.
Caldo-Silva, A, Furtado, GE, Chupel, MU, Bachi, ALL, de Barros, MP, Neves, R, Marzetti, E, Massart, A, Teixeira, AM
Nutrients. 2021;(4)
Abstract
Nowadays, it is accepted that the regular practice of exercise and branched-chain amino acids supplementation (BCAAs) can benefit the immune responses in older persons, prevent the occurrence of physical frailty (PF), cognitive decline, and aging-related comorbidities. However, the impact of their combination (as non-pharmacological interventions) in albumin and the inflammatory markers is not fully understood. Therefore, we investigated the effect of a 40-week multifactorial intervention [MIP, multicomponent exercise (ME) associated or not with BCAAs] on plasma levels of inflammatory markers and albumin in frail older persons (≥75 years old) living at residential care homes (RCH). This study consisted of a prospective, naturalistic, controlled clinical trial with four arms of multifactorial and experimental (interventions-wahshout-interventions) design. The intervention groups were ME + BCAAs (n = 8), ME (n = 7), BCAAs (n = 7), and control group (n = 13). Lower limb muscle-strength, cognitive profile, and PF tests were concomitantly evaluated with plasma levels of albumin, anti- and pro-inflammatory cytokines [Interleukin-10 (IL-10) and Tumor Necrosis Factor-alpha (TNF-α) respectively], TNF-α/IL-10 ratio, and myeloperoxidase (MPO) activity at four different time-points: Baseline (T1), after 16 weeks of multifactorial intervention (T2), then after a subsequent 8 weeks washout period (T3) and finally, after an additional 16 weeks of multifactorial intervention (T4). Improvement of cognitive profile and muscle strength-related albumin levels, as well as reduction in the TNF-α levels were found particularly in ME plus BCAAs group. No significant variations were observed over time for TNF-α/IL-10 ratio or MPO activity. Overall, the study showed that MIP triggered slight alterations in the inflammatory and physical function of the frail older participants, which could provide independence and higher quality of life for this population.
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[The efficiency of branched chain aminoacids (BCAA) in the nutrition of combat sport athletes].
Trushina, EN, Vybornov, VD, Riger, NA, Mustafina, OK, Solntsevа, TN, Timonin, AN, Zilova, IS, Radzhabkadiev, RM
Voprosy pitaniia. 2019;(4):48-56
Abstract
Balanced nutrition of athletes involves the usage of both ordinary products and complexes of functional food ingredients that contribute to improving the performance of athletes, strengthening the immune system. One of the main components of specialized foods that are widely used in sports' nutrition and food supplements are branched chain aminoacids (BCAA): valine, leucine, isoleucine. The aim of the work was to study the effect of the BCAA intake on the parameters of body composition and the immune status of combat sport athletes during the training period. Material and methods. The object of the study was 20 athletes (masters of sports and candidates for masters of sports in combat sports: sambo, judo) at the age of 17-18 years. Athletes were distributed into 2 groups. Athletes of the main group (n=10) for 4 weeks in addition to the main diet were supplemented with BCAA at a dosage of 5 g per day. The athletes of the control group (n=10) received the main diet without BCAA inclusion. Examination of athletes of both groups was carried out at the beginning of the research and after 4 weeks of the observation period. The actual nutrition of athletes and daily energy consumption have been studied, body composition, the quantitative composition of subpopulations of peripheral blood lymphocytes, cytokine profile and hematological parameters have been determined. Results and discussion. As a result of a comprehensive survey of athletes, the positive effect of BCAA intake on the phase angle value (7.35±0.28 vs 6.41±0.32 at the beginning of the study, p<0.05) and muscle mass (25.1±0.8 vs 23.4±0.6 kg, p<0.10) has been demonstrated. In the control group these parameters did not change statistically significantly (7.05±0.25 vs 6.78±0.42 and 24.1±1.7 vs 23.8±1.5 kg). The athletes of the main group showed an increase in erythrocyte hemoglobin content (30.0±0.3 vs 29.0±0.2 pg, p<0.05). The relative content of basophilic leukocytes in athletes of the main group decreased by the end of the observation period - from 0.69±0.05 to 0.54±0.05% (p<0.05), that indicated an increase of immune resistance. The biomarker of the immunotropic effect of BCAA was the suppression of IL-4 production (1.6±0.1 to 1.3±0.1 pg/ml, p<0.05) synthesized by Th2 lymphocytes, with switching response to cellular immunity. Conclusion. The results of this study provide evidence of the effectiveness of BCAA usage in sports' nutrition for maintaining sport performance, immunity, and the adaptive potential of combat sport athletes.
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[Effects of branched amino acids in endurance sports: a review].
Salinas-García, ME, Martínez-Sanz, JM, Urdampilleta, A, Mielgo-Ayuso, J, Norte Navarro, A, Ortiz-Moncada, R
Nutricion hospitalaria. 2014;(2):577-89
Abstract
INTRODUCTION The report issued by the European Food Safety Agency (EFSA) in 2010 on nutrition and health claims, shows that there is no scientific evidence to support supplementation with branched chain amino acids (BCAAs). The aim of this study is to analyze the effects of consumption of BCAAs in endurance sports. METHODS A literature review on the current state of the effect of consumption of dietary supplements of BCAAs. We conducted a search in the PubMed database and snowball strategy. INCLUSION CRITERIA Spanish / English randomized clinical trial related to the consumption of BCAAs, leucine, valine and isoleucine in endurance sports and its effects on muscle damage, athletic performance, central fatigue, anabolic signals during recovery and immune system response published in any country until May 2014. RESULTS Out of 330 studies identified, 14 met the inclusion criteria. The mean of subjects participating in the study was (11.36±7.43). Only two studies included a group of women. The sports that we found in the studies were: run, cycling, combining cycling and running, Olympic distance triathlon and one study included 2 groups of athletes (Olympic distance triathletes and runners). The effects of BCAAs and muscle damage, athletic performance, central fatigue, anabolic signals during recovery period and immune response were studied at different times: before, during and after training or a combination of these. DISCUSSION It is observed that there is a lesser degree of pain and muscle damage, less perceived exertion and mental fatigue, greater anabolic response in recovery period and improved immune response when supplemented with BCAAs, notwithstanding its decision before or during physical activity does not improve athletic performance. No consensus was found in the dose and timing of the most effective decision, although it is more effective if there is 2-3/1/1g relationship between leucine / isoleucine and valine amino acids.
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Nutrition support and infections associated with hepatic resection and liver transplantation in patients with chronic liver disease.
Masuda, T, Shirabe, K, Yoshiya, S, Matono, R, Morita, K, Hashimoto, N, Ikegami, T, Yoshizumi, T, Baba, H, Maehara, Y
JPEN. Journal of parenteral and enteral nutrition. 2013;(3):318-26
Abstract
Malnutrition is common in liver cirrhotic patients who will undergo liver resection or liver transplantation. A precise evaluation of their nutrition status is thus difficult because of the presence of ascites and the edema caused by their impaired protein synthesis. Both perioperative enteral and parenteral nutrition have benefits in reducing the morbidity and mortality of liver surgery, and in general, oral nutrition supplements are recommended. Branched-chain amino acids (BCAAs) promote protein and glycogen synthesis and regulate immune system function. Synbiotics, a combination of pro- and prebiotics, is reported to enhance immune responses. Oral nutrition support with BCAAs, synbiotics, and an immune-enhancing diet have a beneficial effect on preventing the perioperative infections associated with hepatic resection or liver transplantation.