1.
Assessment of the efficacy of a new complex antisensitive skin cream.
Wang, Y, Viennet, C, Jeudy, A, Fanian, F, He, L, Humbert, P
Journal of cosmetic dermatology. 2018;(6):1101-1107
Abstract
BACKGROUND Sensitive skin is frequently complaint in dermatology consultation with cutaneous manifestations such as stinging, redness, dryness, and burning sensation that affect the quality of life. Its pathogenesis is mainly related to dysfunction of neurosensory, skin barrier, and also immune activity. The treatment is generally based on continuous and topical therapy by nonirritating complex. OBJECTIVE To evaluate the antisensitive function of a new complex cream composed by Yunnan Portulaca oleracea extract, Prinsepia utilis oil, beta-glucan, and sodium hyaluronate extracted from mushroom. METHODS A randomized double-blind and self-control study was conducted on 20 selected volunteers with sensitive skin. Subjects applied the test cream to 1 side of the face, and the control cream (tolerance-extreme cream) to the other side of the face, twice daily over 28 days. Evaluations were performed at baseline and at 28 days. Expert clinical grading of facial skin including dryness, roughness, desquamation, and erythema was assessed. Subject self-assessment questionnaires, digital photography and noninvasive bioinstrumentation of hydration, transepidermal water loss, lipid index, skin texture, and wettability were also included in the study. RESULTS Products were well tolerated. For all parameters studied, no significant difference was observed between test and control creams. Results showed that test cream provided a statistically significant improvement in clinical grading scores for dryness, roughness, and erythema at 28 days compared to baseline. In addition, statistically significant improvement of skin hydration and texture parameters (eg, smoothness and roughness) was demonstrated. Volunteers' questionnaire revealed self-perceived benefits consistent with expert visual grading. CONCLUSION This study confirmed the effectiveness and tolerance of the new complex cream in subjects with sensitive skin. The test cream could serve as a daily care moisturizer for face.
2.
Periodontal Therapy with 0.25%Lemongrass Oil Mouthwash in Reducing Risk of Cardiovascular Diseases: A 3-Arm Prospective Parallel Experimental Study.
Subha, DS, Pradeep, T
Ethiopian journal of health sciences. 2017;(5):531-540
Abstract
BACKGROUND Periodontal disease is associated with cardiovascular diseases because of its role in host immune-inflammatory response. Serum lipids are the commonest risk factors between periodontal disease and cardiovascular diseases. MATERIALS AND METHOD A double blinded randomised clinical trial was carried out among 45 subjects with generalised severe periodontitis. They were divided into 3-groups of 15 subjects each. Group A: 0.25% lemongrass oil mouthwash, Group B: 0.12% chlorhexidine mouthwash and Group C: Oral prophylaxis only Group. Oral examinations like assessment of Probing Pocket Depth and Clinical Attachment Loss and Bio-chemical tests like assessment of C-Reactive Protein, Total Cholesterol, High Density Lipid, Low Density Lipid and triglycerides were conducted at baseline followed by oral prophylaxis at the same visit. Reassessment of the above mentioned parameters were done after 3 months of intervention. Data so collected were subjected for statistical analysis using SPSS ver. 20.0. RESULTS A statistically significant reduction in C-Reactive Protein, Probing Pocket Depth, Clinical Attachment Loss, Total Cholesterol and Low Density Lipid level in 0.25% lemongrass oil mouthwash group was found. On comparing a statistically significant difference was observed for the post intervention scores of Probing Pocket Depth and Clinical Attachment Loss only; for Group A v/s C and Group B v/s C. CONCLUSION 0.25% Lemongrass oil mouthwash was found to be a good herbal alternative; both in the treatment of chronic periodontitis and reduction in the level of serum markers of Cardio Vascular Diseasess.