1.
A systematic review of antiglycation medicinal plants.
Asgharpour Dil, F, Ranjkesh, Z, Goodarzi, MT
Diabetes & metabolic syndrome. 2019;(2):1225-1229
Abstract
BACKGROUND AND OBJECTIVES The present review shows a list of anti-glycation plants with their anti-glycation activity mechanisms that can attract the attention of pharmacologist for further scientific research towards finding better remedy for diabetic complications. MATERIALS Google scholar, Pubmed, Web of Science and Scopus were searched. The terms were advanced glycation end products (AGEs), medicinal plants, antiglycation products. RESULTS plants that studied in this review inhibit glycation in several possible mechanisms. Some of these plants inhibit the production of shiff base and amadori products. The others inhibit the generation of amadori products in the advanced phase. Some others blocked the aggregation of AGEs and some plants have antioxidant activity and reduce AGEs formation by preventing oxidation of amadori product and metal-catalyzed glucoxidation. CONCLUSION This review can help pharmacologist to find antiglycation natural substance that can be useful in treatment of diabetic complications.
2.
Botanical drugs: challenges and opportunities: contribution to Linnaeus Memorial Symposium 2007.
Liu, Y, Wang, MW
Life sciences. 2008;(9-10):445-9
Abstract
Plants have been a source of therapeutic agents for more than 5000 years. Approximately 25% of the modern medications are developed from plants. Botanical drugs, simply defined as clinically validated pharmaceuticals of plant origin, typically contain a multi-component composition derived from herbal practices. An obvious advantage of botanical drugs is their history of use and hence, that the therapeutic window has already been understood through experience. Following vigorous scientific validation and appropriate regulatory procedures, some of the ancient remedies may prove to be useful in mitigating certain ailments (e.g., Alzheimer's disease, schizophrenia, metabolic syndrome, etc.) where contemporary therapies often lack desired effectiveness. Such a complementary approach has received tremendous attention among medical professionals, governmental agencies and the general public across the world. A few recently approved botanical prescriptions in the USA and Europe, albeit for topical application, have opened a window of opportunity in terms of regulatory passages in the West. One of the major challenges we face is the standardization of biological materials from natural sources. New technologies to modernize traditional herbs into mainstream pharmaceutical products are being evaluated with the ultimate goal of maximizing the opportunities and overcoming the challenges.
3.
Preparation of botanical samples for biomedical research.
Liu, Z
Endocrine, metabolic & immune disorders drug targets. 2008;(2):112-21
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Abstract
Plants are chemical storehouses, a fact which has driven countless multidisciplinary quests for bioactive compounds. As the very first step of botanical research, the whole desire is to find "hit" plants with specific bioactivities. It is logical to use some strategies that can maximize the chances of finding these "hits" with limited time and resources. In addition to selecting the right plants for screening, how the plant extracts are prepared can also influence the bioactivity screening outcomes. An extract from the same plant material can be quite different in chemical composition having different preparations. Because of the complex mixture nature of plant extracts, it is possible artifact activities may be observed. Thus confirmatory activity tests are often necessary to warrant the next laborious isolation step. A bioassay directed isolation approach may be the most efficient in identifying the bioactive compounds because of the narrowed focus at each isolation step, but a phytochemistry isolation approach is appropriate to characterize a purified bioactive extract. In fact, these two approaches can be taken intermittently whenever efficiency can be improved. Finally, use of the identified active compounds is now broader. In addition to determining a lead compound to continue a drug development path, there is an increasing interest in support for the use of botanical extracts as botanical drugs. Instead of dropping the extract after extracting the lead compound, the natural analogues representing the purified extract now have a chance to become leading compounds in the pursuit of novel therapies for metabolic syndrome and other diseases.