Abstract
BACKGROUND Migraine occurs with a high prevalence of 18 per cent. Management requires a tailored regimen of pharmacological and other measures based on individual clinical history. In some patients, allergen-specific IgG has been suspected to be involved in their mechanism, however, serological methods to investigate such possibility, are seldomly used. OBJECTIVE The aim of this study was to investigate allergen-specific IgG in serum of patients with migraine refractory to traditional treatment. MATERIAL AND METHODS Serum antibodies to specific 108 food allergens were measured by enzyme immunoassay from 56 patients with migraine and a control group without migraine. RESULTS In addition to statistical significant differences in the number of positives for IgG food allergens between patients with migraine and a controlled group, elimination diets successfully control the migraine without the need of medications. CONCLUSION According to the results obtained, serum IgG antibodies to common food should be investigated in patients with migraine.
