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The correlation between pretreatment cytokine expression patterns in peripheral blood mononuclear cells with chronic hepatitis C outcome.

Department of Hepatology and Acquired Immunodeficiences, Medical University of Warsaw, Warsaw, Poland. joannaj108@hotmail.com. Division of Psychotherapy and Psychosomatic Medicine, Wrocław Medical University, Wrocław, Poland. tomasz.pawlowski@am.wroc.pl. Department of Immunopathology of Infectious Diseases, Medical University of Warsaw, Warsaw, Poland. tlaskus@yahoo.com. Department of Infectious Diseases, Hepatology and Acquired Immune Deficiences, Wrocław Medical University, Wrocław, Poland. mzalewska@k.pl. Department of Infectious Diseases, Hepatology and Acquired Immune Deficiences, Wrocław Medical University, Wrocław, Poland. minglot@interia.pl. Department of General Surgery and Clinical Nutrition, Medical University of Warsaw, Warsaw, Poland. sylwiao@hotmail.com. Department of Immunopathology of Infectious Diseases, Medical University of Warsaw, Warsaw, Poland. kperlejewski@wum.edu.pl. Department of Immunopathology of Infectious Diseases, Medical University of Warsaw, Warsaw, Poland. ibukowska@wum.edu.pl. Department of Immunopathology of Infectious Diseases, Medical University of Warsaw, Warsaw, Poland. kamila.caraballo@wum.edu.pl. Department of Immunopathology of Infectious Diseases, Medical University of Warsaw, Warsaw, Poland. agnieszka.pawelczyk@wum.edu.pl. Municipal Hospital of Infectious Diseases, Warsaw, Poland. pzabek@zakazny.pl. Department of Immunopathology of Infectious Diseases, Medical University of Warsaw, Warsaw, Poland. marek.radkowski@wum.edu.pl.

BMC infectious diseases. 2015;:556
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Abstract

BACKGROUD Cytokine response against hepatitis C virus (HCV) is likely to determine the natural course of infection as well as the outcome of antiviral treatment. However, the role of particular cytokines remains unclear. The current study analyzed activation of cytokine response in chronic hepatitis C patients undergoing standard antiviral treatment. METHODS Twenty-two patients were treated with pegylated interferon and ribavirin. Twenty-six different cytokine transcripts were measured quantitatively in peripheral blood mononuclear cells (PBMC) before and after therapy and correlated with therapy outcome as well as with clinical and liver histological data. RESULTS We found that patients who achieved sustained virological response (SVR) showed higher pretreatment cytokine response when compared to subjects in whom therapy was unsuccessful. The differentially expressed factors included IL-8, IL-16, TNF-α, GM-CSF, MCP-2, TGF-β, and IP-10. Serum ALT activity and/or histological grading also positively correlated with the expression of IL-1α, IL-4, IL-6, IL-10, IL-12, IL-15, GM-CSF, M-CSF, MCP-2 and TGF-β. CONCLUSION Pretreatment activation of the immune system, as reflected by cytokines transcripts upregulation, positively correlates with treatment outcome and closely reflects liver inflammatory activity.

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Publication Type : Clinical Trial

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