AstraZeneca Pharmaceuticals, Alderley Park, SK10 4TF, Macclesfield, Cheshire, UK. paul.martin@astrazeneca.com. AstraZeneca, Wilmington, DE, USA. Michael.gillen@astrazeneca.com. Quintiles Drug Research Unit, Guy's Hospital, London, UK. Quintiles Phase I Unit, 6700 W 115th St, Overland Park, KS, USA. Former-AstraZeneca, Macclesfield, Cheshire, UK. AstraZeneca Pharmaceuticals, Alderley Park, SK10 4TF, Macclesfield, Cheshire, UK. AstraZeneca, Cambridge, Cambridgeshire, UK. Covance, Madison, WI, USA.