UCL Institute of Cardiovascular Sciences, University College London, London, UK; National Institute for Health Research, UCL Hospitals Biomedical Research Centre, London, UK. Medicines Monitoring Unit, Molecular and Clinical Medicine, University of Dundee, Dundee, UK. Clinical Pharmacology Unit, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Centre of Circulatory Health, Imperial College London, London, UK. BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK. Department of Nutritional Sciences, King's College London, London, UK. William Harvey Research Institute, Queen Mary University of London, London, UK; NIHR Barts Hospital Biomedical Research Centre, London, UK. William Harvey Research Institute, Queen Mary University of London, London, UK; NIHR Barts Hospital Biomedical Research Centre, London, UK. Electronic address: morris.brown@qmul.ac.uk.