Department of Physiology and Pharmacology , University of Calgary , Calgary , Alberta , Canada T2N 4N1. Department of Biochemistry and Molecular Biology , University of Calgary , Calgary , Alberta , Canada T2N 4N1. McCaig Institute for Bone and Joint Health , University of Calgary , Calgary , Alberta , Canada T2N 4N1. Department of Comparative Biology and Experimental Medicine , University of Calgary , Calgary , Alberta , Canada T2N 4N1. Departments of Molecular Medicine and Integrative Structural and Computational Biology , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States. Department of Pathology and Laboratory Medicine and Department of Chemistry , University of British Columbia , Vancouver , British Columbia V6T 1Z2 , Canada. Department of Medicine, Division of Gastroenterology , University of Calgary , Calgary , Alberta , Canada T2N 4N1. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Victoria , Parkville , Australia. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences , Monash University , Parkville , Victoria , Australia. Department of Oral and Maxillofacial Surgery , New York University College of Dentistry, Bluestone Center for Clinical Research , New York , New York , United States.