Department of Medicine, Boston University School of Medicine, 801 Massachusetts Avenue, Crosstown Building, 2nd Floor, Boston, MA, 02118, USA. kaku@bu.edu. Department of Medicine, Vanderbilt University School of Medicine; Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, USA. matthew.s.freiberg@vanderbilt.edu. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Department of Medicine, Boston Medical Center, Boston, MA, USA. Department of Biostatistics and Data Coordinating Center, Boston University School of Public Health, Boston, MA, USA. Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA. Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain. Department of Infectious Diseases and Epidemiology, Smorodintsev Research Institute of Influenza, First Pavlov State Medical University, St. Petersburg, Russia. First Pavlov State Medical University, V. M. Bekhterev National Research Medical Center for Psychiatry and Neurology, St. Petersburg, Russia. Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.