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Nano-copper enhanced flexible device for simultaneous measurement of human respiratory and electro-cardiac activities.

Advanced Micro and Nanoinstruments Center (AMNC), School of Mechanical & Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. liwang@qlu.edu.cn. Advanced Micro and Nanoinstruments Center (AMNC), School of Mechanical & Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. Department of Mechanical and Process Engineering, University of Duisburg Essen, Forsthausweg, 247057, Germany. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China. Advanced Micro and Nanoinstruments Center (AMNC), School of Mechanical & Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. chenjun@qlu.edu.cn. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. yunlun.lee@hotmail.com.

Journal of nanobiotechnology. 2020;(1):82
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Abstract

BACKGROUND Dysfunction of human respiratory and electro-cardiac activities could affect the ability of the heart to pump blood and the lungs to inhale oxygen. Thus, a device could simultaneously measure electro-cardiac signal and respiratory pressure could provide vital signs for predicting early warning of cardio-pulmonary function-related chronic diseases such as cardiovascular disease, and respiratory system disease. RESULTS In this study, a flexible device integrated with piezo-resistive sensing element and voltage-sensing element was developed to simultaneously measure human respiration and electro-cardiac signal (including respiratory pressure, respiration frequency, and respiration rhythm; electro-cardio frequency, electro-cardio amplitude, and electro-cardio rhythm). When applied to the measurement of respiratory pressure, the piezo-resistive performance of the device was enhanced by nano-copper modification, which detection limitation of pressure can reduce to 100 Pa and the sensitivity of pressure can achieve to 0.053 ± 0.00079 kPa-1. In addition, the signal-to-noise ratio during bio-electrical measurement was increased to 10.7 ± 1.4, five times better than that of the non-modified device. CONCLUSION This paper presents a flexible device for the simultaneous detection of human respiration and cardiac electrical activity. To avoid interference between the two signals, the layout of the electrode and the strain sensor was optimized by FEA simulation analysis. To improve the piezo-resistive sensitivity and bio-electric capturing capability of the device, a feather-shaped nano-copper was modified onto the surface of carbon fiber. The operation simplicity, compact size, and portability of the device open up new possibilities for multi-parameter monitoring.