Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: edith.zemanick@childrenscolorado.org. Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland OH USA; Rainbow Babies and Children's Hospital, Cleveland OH USA. Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland OH USA. Department of Medicine and the Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL USA. Cystic Fibrosis Foundation, Bethesda, MD USA. Seattle Children's Research Institute, Seattle, WA 98145, USA. Seattle Children's Research Institute, Seattle, WA 98145, USA; Department of Biostatistics and Pediatrics, University of Washington, Seattle, WA 98195, USA.