Experimental Pathology and Therapeutics Group, Research Center (CI-IPOP), Portuguese Institute of Oncology, 4200-072, Porto, Portugal. Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313, Porto, Portugal. Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135, Porto, Portugal. Institute for Biomedical Engineering (INEB), University of Porto, 4200-135, Porto, Portugal. REQUIMTE-LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences of the University of Porto, 4169-007, Porto, Portugal. Cancer Genetics Group, Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072, Porto, Portugal. Immunology Department, Portuguese Institute of Oncology of Porto, 4200-072, Porto, Portugal. Health School of University Fernando Pessoa, 4249-004, Porto, Portugal. Department of Surgical Oncology, Portuguese Institute of Oncology, 4200-072, Porto, Portugal. Porto Comprehensive Cancer Center (P.ccc), 4200-072, Porto, Portugal. Experimental Pathology and Therapeutics Group, Research Center (CI-IPOP), Portuguese Institute of Oncology, 4200-072, Porto, Portugal. jose.a.ferreira@ipoporto.min-saude.pt. Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313, Porto, Portugal. jose.a.ferreira@ipoporto.min-saude.pt. Porto Comprehensive Cancer Center (P.ccc), 4200-072, Porto, Portugal. jose.a.ferreira@ipoporto.min-saude.pt.