Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Department of Epidemiology and Prevention, IRCCS Neuromed, 86077 Pozzilli, Italy. Department of Neuroscience and Rehabilitation, School of Medicine, University of Ferrara, 44121 Ferrara, Italy. Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy. Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, 21100 Varese-Como, Italy. Laboratory of Molecular Oncology, IDI-IRCCS, 00167 Rome, Italy.