Back to Search Results

Impact of Permanent Post-thyroidectomy Hypoparathyroidism on Self-evaluation of Quality of Life and Voice: Results From the National QoL-Hypopara Study.

Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Hôtel Dieu, CHU Nantes, Place Alexis Ricordeau, Nantes CEDEX, France. Université de Nantes, Quai de Tourville, Nantes. Service de Néphrologie-Immunologie Clinique, CHU de Nantes, Nantes cedex, France. CHU Lille, Université de Lille, Chirurgie Générale et Endocrinienne Lille, France. Endocrinologie, Maladies Métaboliques et Nutrition, CHU de Nantes, Hôpital Laënnec, boulevard Jacques-Monod, Saint-Herblain, France. CHU de Limoges - Hôpital Dupuytren, Chirurgie Digestive, Générale et Endocrinienne, Limoges cedex, France. CHU Angers, Chirurgie Digestive et Endocrinienne, Angers cedex 09, France. Université de Lorraine, Département de Chirurgie Viscérale, Métabolique et Cancérologique (CVMC), CHRU Nancy, Hôpital de Brabois (7 étage), Vandœuvre-lès-Nancy, France. Hôpital Lyon-Sud, Chirurgie Digestive et Endocrinienne, 69495 Pierre Bénite cedex, France, 9bis- Research on Healthcare Professionals and Performance (RESHAPE) UMR- Université Claude Bernard Lyon 1 - INSERM 1290. Domaine Rockefeller- 2 étage (couloir CD), Lyon, France. Service de Chirurgie Digestive, Bariatrique et Endocrinienne, Hôpitaux Universitaires Paris Seine-Saint-Denis, Hôpital Avicenne, 93000, France. AP-HM - Hôpital de La Conception, Chirurgie Générale, Marseille, France. Service Chirurgie Digestive, Sorbonne University, CHU Pitié-Salpêtrière, Paris, France. Plateforme de Méthodologie et de Biostatistique - DRCi - CHU de Nantes, Nantes, France.

Annals of surgery. 2021;(5):851-858
Full text from:

Other resources

Abstract

OBJECTIVE The aim of this study was to compare the quality of life (mental health) and voice in patients with or without permanent hypoparathyroidism after total thyroidectomy. SUMMARY BACKGROUND DATA Permanent hypoparathyroidism is an underestimated complication of thyroid surgery owing to suppression of parathormone secretion. Few studies have evaluated the consequences of hypoparathyroidism on quality of life and none has studied its effects on voice. METHODS The QoL-hypopara study (ClinicalTrial.gov NCT04053647) was a national observational study. Adult thyroidectomized patients were included between January and June 2020. A serum parathormone level <15 pg/mL >6 months after surgery defined permanent hypoparathyroidism. Patients answered the MOS-36-item short-form health (SF-36), the Voice Handicap Index (VHI) surveys, and a list of questions regarding their symptoms. RESULTS A total of 141 patients were included, 45 with permanent hypoparathyroidism. The median period between thyroid surgery and the questionnaire was 6 (Q1-Q3 4-11) and 4 (4-5) years in hypoparathyroid patients and controls respectively. Hypoparathyroid patients presented a reduced median mental score ratio (SF-36) [0.88 (Q1-Q3 0.63-1.01) vs 1.04 (0.82-1.13), P = 0.003] and a lower voice quality (incidence rate ratio for total VHI 1.83-fold higher, P < 0.001). In multivariable analysis, hypoparathyroidism [-0.17 (95% confidence interval -0.28 to -0.07), P = 0.002], but not age, female sex, thyroid cancer, or abnormal TSH level, was associated with the reduced mental score ratio. Myalgia, joint pain, paresthesia, tetany, anxiety attack, and exhaustion were the most common symptoms among hypoparathyroid patients (>50%). CONCLUSIONS Hypoparathyroid patients present significantly impaired quality of life, lower voice quality, and frequent symptoms. These results reinforce the importance of preventing this complication.

Methodological quality

Publication Type : Multicenter Study ; Observational Study

Metadata

MeSH terms : Thyroidectomy ; Voice