Podcast Summary
A unique deep dive into uric acid levels and their impact on metabolic health. Rupy and David discuss how we now have less uricase to break down uric acid compared to our ancestors and what this means living in our current environment with an abundance of calorie dense food and home comforts. Downstream effects of elevated uric acid levels are considered related to metabolic dysfunction as they have been shown to correlate with hypertension, insulin resistance and inflammation due to both the inhibition of nitric oxide and enhancing gut permeability. They look at how to mitigate the effects of high uric acid levels by reducing fructose consumption, and increasing dietary bioflavanoids and hormetic stress.
