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Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk.
Solomon, A, Handels, R, Wimo, A, Antikainen, R, Laatikainen, T, Levälahti, E, Peltonen, M, Soininen, H, Strandberg, T, Tuomilehto, J, et al
Journal of Alzheimer's disease : JAD. 2021;82(4):1461-1466
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Plain language summary
Early identification of individuals at-risk of dementia is essential for effective preventive strategies. The aim of this study was to investigate the effect of a multidomain lifestyle intervention on the risk of dementia. This study is a post-hoc analyses of intervention effects on change in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Dementia Risk Score. The CAIDE score was used to select at-risk participants to the FINGER trial. FINGER is a multicentre study conducted in 6 centres in Finland. Results show a significant beneficial intervention effect, especially in women, on reducing estimated dementia risk measured by the CAIDE score. Authors conclude that CAIDE risk score can be used as a tool to communicate dementia risk, and to select persons that may benefit from lifestyle interventions.
Abstract
We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 %CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.
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Coping behaviors associated with decreased anxiety and depressive symptoms during the COVID-19 pandemic and lockdown.
Fullana, MA, Hidalgo-Mazzei, D, Vieta, E, Radua, J
Journal of affective disorders. 2020;275:80-81
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Worldwide, COVID-19 pandemic and lockdown might increase anxiety and depressive symptoms. The authors conducted an online survey of the general Spanish adult population two weeks after an official lockdown was established across the country as a quarantine. Results showed that: - sixty-five percent of the participants (mean age = 47 years; 73% females) reported anxiety or depressive symptoms (anxiety: 39% mild, 11% moderate, 4% severe; depressive: 29% mild, 9% moderate, 6% severe). - following a balanced diet and not reading news/updates about COVID-19 very often were the best predictors of lower levels of anxiety symptoms. - following a balanced diet, following a routine, not reading news/updates about COVID-19 very often, taking the opportunity to pursue hobbies, and staying outdoors or looking outside were the best predictors of lower levels of depressive symptoms. Authors conclude that simple coping behaviours may protect against anxiety and depressive symptoms during the COVID-19 pandemic and lockdown.
Abstract
BACKGROUND The COVID-19 pandemic and lockdown might increase anxiety and depressive symptoms, but some behaviors may protect against them. METHOD To provide a preliminary evidence of the behaviors associated with decreased symptoms in the current COVID-19 pandemic and lockdown, we conducted a survey of 5545 adult individuals from the Spanish general population, two weeks after an official lockdown was established across the country. RESULTS Sixty-five percent of the sample reported anxiety or depressive symptoms. Following a healthy/balanced diet and not reading news/updates about COVID-19 very often were the best predictors of lower levels of anxiety symptoms. Following a healthy/balanced diet, following a routine, not reading news/updates about COVID-19 very often, taking the opportunity to pursue hobbies, and staying outdoors or looking outside were the best predictors of lower levels of depressive symptoms. LIMITATIONS Cross-sectional nature and use of sample of convenience. CONCLUSIONS This study suggests that "simple" coping behaviors may protect against anxiety and depressive symptoms during the COVID-19 pandemic and lockdown.