1.
Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia-A Systematic Review.
Fernández-Araque, A, Verde, Z, Torres-Ortega, C, Sainz-Gil, M, Velasco-Gonzalez, V, González-Bernal, JJ, Mielgo-Ayuso, J
Journal of clinical medicine. 2022;11(9)
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Plain language summary
Fibromyalgia (FM) is characterised by widespread chronic pain, fatigue, sleep disturbances, and cognitive impairment. As a result of oxidative stress, reactive oxygen species (ROS) are produced and improperly disposed of, resulting in peripheral and central sensitisations, and a reduction of the pain threshold in FM patients. It is well known that antioxidants are protective against oxidative stress and that reducing antioxidant levels can result in increased pain in patients with FM. An overview of 17 studies was conducted to evaluate the effect of antioxidant supplementation on pain perception and the appropriate duration of treatment for FM patients in this systematic review. This systematic review found that supplementation with Fibromyalgine® (Fib) (that contains vitamin C, acerola ginger root, and freeze-dried royal jelly), 300-400 gm/d of coenzyme Q10 alone in combination with Pregabalin, ferric carboxymaltose, vitamin C, E, and Nigella sativa, magnesium + amitriptyline, acetyl L-carnitine, and Sun Chlorella™ green algae are effective in reducing pain perception in FM patients. In patients with FM, alpha-lipoic acid supplementation significantly reduced pain scores. 80% of FM patients reported reduced pain after supplement treatment for at least six weeks. There is a need for further robust long-term studies to confirm the effectiveness and clinical applicability of antioxidants in the management of FM, as well as to identify the pathophysiology of FM. This research may, however, be used by healthcare professionals to gain a better understanding of the potential benefits of antioxidants in the treatment of pain associated with FM.
Abstract
In recent years, antioxidant supplements have become popular to counteract the effects of oxidative stress in fibromyalgia and one of its most distressing symptoms, pain. The aim of this systematic review was to summarize the effects of antioxidant supplementation on pain levels perceived by patients diagnosed with fibromyalgia. The words used respected the medical search terms related to our objective including antioxidants, fibromyalgia, pain, and supplementation. Seventeen relevant articles were identified within Medline (PubMed), Scopus, Web of Science (WOS), the Cochrane Database of Systematic Review, and the Cochrane Central Register of Controlled Trials. This review found that antioxidant supplementation is efficient in reducing pain in nine of the studies reviewed. Studies with a duration of supplementation of at least 6 weeks showed a benefit on pain perception in 80% of the patients included in these studies. The benefits shown by vitamins and coenzyme Q10 are remarkable. Further research is needed to identify the effects of other types of antioxidants, such as extra virgin olive oil and turmeric. More homogeneous interventions in terms of antioxidant doses administered and duration would allow the effects on pain to be addressed more comprehensively.
2.
[Abnormal effect of nitrosation inhibitors in human gastric juice].
Ermilov, VB, Shendrikova, IA, Volkov, DP, Stefanenko, IuF, Chernomordikov, VG
Voprosy onkologii. 1986;32(10):58-64
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Plain language summary
Growth faltering in infancy establishes a trajectory for lifelong health of the individual and population. Stunted growth is due to the combined effect inadequate diet (malnutrition) and infection that affects the gut mucosal lining, with increased nutrient loss due to maldigestion and malabsorption, and increased nutritional requirements due to inflammation. Intestinal integrity in infants has been improved through supplementation with vitamin A and Zinc. Iron deficiency anemia may impair intestinal integrity. This study investigates the effects of complementary fortified food on gut integrity and systemic inflammation among Zambian infants age 6-18months. Infants of 6 months +/- 2 weeks old were randomised to either 50g/day richly fortified porridge mix or 50g basal porridge mix fortified with micronutrient levels planned for maize fortification in Zambia. At 18 months, the richly fortified porridge group had a significantly higher mean lactulose to mannitol ratio than the basal-fortified group, indicating they had significantly higher intestinal permeability. This effect was not modified by child’s sex, maternal HIV status, concurrent breast-feeding or baseline anaemia. The biological significance of this increase in intestinal permeability is questionable, however further research is warranted to understand the effect of iron supplementation on gut permeability in infants with normal iron status. In conclusion, a richly fortified complementary/replacement food did not benefit and may have worsened intestinal permeability. Further investigation into local interactions of key micronutrients with gut integrity, particularly in micronutrient-replete infants is needed.
Abstract
The paper discusses the effect of vitamins C and E and Plantaglucide on nitroso compounds yield in the course of nitrosation of amines in human gastric juice. The study group included 56 subjects. The above drugs capable of inhibiting in vitro nitrosation produced an anomalous effect in gastric juice of some subjects, i.e. potentiated nitroso compounds yield in nitrosation of amines by sodium nitrite. The said action of vitamins C and E was apparent in dimethylamine and amidopyrine nitrosation but it was not in morpholine nitrosation. Sharply increased levels in nitroso compounds were observed in some mice fed precursors of nitroso compounds in combination with vitamin C and Plantaglucide. These data point to an anomalous effect of the drugs on the body.